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At. Arthur M. Sack/er ~ C O L L O Q U I A ~ OF THE N ATIO N AL ACADEMY OF SCIENCES Chemical Communication in a Post-Genomic WorIcl National Academy of Sciences Washington, D.C. ~ .. rj . f. C ~ ~ i. i ~ ,. .- i ~ ,. .. ~1q ~ ! ,_ .. ! an,,.'! ' ,r

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Arthur M. Sackler, M.D. 1 91 3-1 987 Born in Brooklyn, New York, Arthur M. Sackler was edu- cated in the arts, sciences, and humanities at New York University. These interests remained the focus of his life, as he became widely known as a scientist, art collector, and philan- thropist, endowing institutions of learning and culture through- out the world. He felt that his fundamental role was as a doctor, a vocation he decided upon at the age of four. After completing his internship and service as house physician at Lincoln Hospital in New York City, he became a resident in psychiatry at Creed- moor State Hospital. There, in the 1940s, he started research that resulted in more than 150 papers in neuroendocrinology, psychiatry, and experimental medicine. He considered his scientific research in the metabolic basis of schizophrenia his most significant contribution to science and served as editor of the Journal of Clinical and Experimental Psychobiology from 1950 to 1962. In 1960 he started publication of Medical Tribune, a weekly medical newspaper that reached over one million readers in 20 countries. He established the Laboratories for Therapeutic Research in 1938, a facility in New York for basic research that he directed until 1983. As a generous benefactor to the causes of medicine and basic science, Arthur Sackler built and contributed to a wide range of scientific institutions: the Sackler School of Medicine established in 1972 at Tel Aviv University, Tel Aviv, Israel; the Sackler Institute of Graduate Biomedical Science at New York University, founded in 1980; the Arthur M. Sackler Science Center dedicated in 1985 at Clark University, Worcester, Massachusetts; and the Sackler School of Graduate Biomedical Sciences, established in 1980, and the Arthur M. Sackler Center for Health Communications, established in 1986, both at Tufts University, Boston, Massachusetts. His pre-eminence in the art world is already legendary. According to his wife Jillian, one of his favorite relaxations was to visit museums and art galleries and pick out great pieces others had overlooked. His interest in art is reflected in his philanthropy; he endowed galleries at the Metropolitan Museum of Art and Princeton University, a museum at Harvard University, and the Arthur M. Sackler Gallery of Asian Art in Washington, DC. True to his oft-stated determination to create bridges between peoples, he offered to build a teaching museum in China, which Jillian made possible after his death, and in 1993 opened the Arthur M. Sackler Museum of Art and Archaeology at Peking University in Beijing. In a world that often sees science and art as two separate cultures, Arthur Sackler saw them as inextricably related. In a speech given at the State University of New York at Stony Brook, Some reflections on the arts, sciences and humanities, a year before his death, he observed: "Communication is, for me, theprimum movens of all culture. In the arts. . . I find the emotional component most moving. In science, it is the intellectual content. Both are deeply interlinked in the humanities." The Arthur M. Sackler Colloquia at the National Academy of Sciences pay tribute to this faith in communication as the prime mover of knowledge and culture. ~ . ~ ~ ~ ~~..~ ._ of. _ ,~.~..~ _

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1 -AS e~e. m - ~11111111 I.1 11~1: .L ~ Contents Papers from the Arthur M. Sackler Colloquium of the National Academy of Sciences INTRODUCTIONS 14513 Chemical communication in a post-genomic world May R. Berenbaum and Gene E. Robinson 14514 Understanding the chemistry of chemical communication: Are we there yet? Jerrold Meinwald 14517 Chemical ecology: Can it survive without natural products chemistry? Thomas Eisner COLLOQUIUM PAPERS 14519 Pheromone-mediated gene expression in the honey bee brain Christina M. Grozinger, Noura M. Sharabash, Charles W. Whitfield, and Gene E. Robinson 14526 Drosophila Gr5a encodes a taste receptor tuned to trehalose Sylwester Chyb, Anupama Dahanukar, Andrew Wickens, and John R. Carlson 14531 Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans Wolfgang Liedtke, David M. Tobin, Cornelia I. Bargmann, and Jeffrey M. Friedman 14537 Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster Hugh M. Robertson, Coral G. Warr, and John R. Carlson 14543 A genomic perspective on nutrient provisioning by bacterial symbionts of insects Nancy A Moran, Gordon R. Plague, Jonas P. Sandstrom, and Jennifer L. Wilcox 14549 Chemical communication among bacteria Michiko E. Taga and Bonnie L. Bassler 14555 Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species Grego~y L. Challis and David A. Hopwood 14562 Efficient oxidative folding of conotoxins and the radiation of venomous cone snails Grzegorz Bulaj, Olga Buczek, Ian Goodsell, Elsie C:. Jimenez, Jessica Kranski, Jacob S. Nielsen, James E. Garrett, and Baldomero M. Olivera 14569 Non-self recognition, transcriptional reprogramming, and secondary metabolite accumulation during plant/pathogen interactions Klaus Hahlbrock, Pawel Bednarek, Ingo Ciolkowski, Bjorn Hamberger, Andreas Heise, Hiltrud Liedgens, Elke Logemann, Thorsten Nurnberger, Elmon Schmelzer, Imre E. Somssich, and Jianwen Tan 14577 Systemins: A functionally defined family of peptide signals that regulate defensive genes in Solanaceae species Clarence A. Ryan and Grego~y Pearce 14581 Manduca sexta recognition and resistance among allopolyploid Nicotiana host plants Yonggen Lou and Ian T. Baldwin 14587 Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus Juergen Kroymann, Susanne Donnerhacke, Domenica Schnabelrauch, and Thomas Mitchell-Olds 14593 Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Specificity and substrate encounter rate Weimin Li, Mary A. Schuler, and May R. Berenbaum 9179 Molecular genetics and evolution of pheromone biosynthesis in Lepidoptera Wendell L. Roelofs and Alejandro P. Rooney

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