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Immunization Safety Review: Vaccines and Autism (2004)
Board on Health Promotion and Disease Prevention (HPDP)
Institute of Medicine (IOM)

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. "Appendix C: Thimerosal Content in Licensed Vaccines." Immunization Safety Review: Vaccines and Autism. Washington, DC: The National Academies Press, 2004.

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Immunization Safety Review: Vaccines and Autism

Appendix C
Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)

Page
183

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OCR for page 183
Immunization Safety Review: Vaccines and Autism Appendix C Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)

OCR for page 184
Immunization Safety Review: Vaccines and Autism TABLE C-1 Mercury Content from Thimerosal in the Routinely Recommended Pediatric Vaccines1 in the United States, April 2004 Vaccine Brand Name Manufacturer Hg [μg/dose] DTaP (Diphtheria and tetanus toxoids and acellular pertussis) Tripedia Aventis Pasteur, Inc. ≤0.3 Infanrix Glaxo-SmithKline 0 Daptacel Aventis Pasteur, Ltd 0 Td1 (Tetanus and diphtheria toxoids) None Aventis Pasteur, Inc. 25 Decavac Aventis Pasteur, Inc. = 0.3 None Aventis Pasteur, Ltd 0 None Mass Public Health 8.3 DTaP-Hib (Diphtheria and tetanus toxoids with acellular pertussis combined with Haemophilus influenzae type b) TriHIBit2 Aventis Pasteur ≤0.3 Hib (Haemophilus influenzae type b) ActHIB/OmniHib Aventis Pasteur, SA 0 HibTITER (Single dose) Wyeth-Lederle 0 PedvaxHIB liquid Merck 0 Hib/HepB (Haemophilus influenzae type b combined with Hepatitis B ) COMVAX Merck 0 Hep B (Hepatitis B) (pediatric formulation) Engerix B Glaxo-SmithKline <0.5 Recombivax HB Merck 0 Influenza Fluzone3 Aventis Pasteur, Inc. 12.5 Fluzone Aventis Pasteur, Inc. ≤0.5ug/ (Preservative Free)   0.25mL dose Pneumococcal Prevnar (pneumoconjugate) Wyeth 0 IPV (Inactivated polio vaccine) IPOL Aventis Pasteur, SA 0 Poliovax Aventis Pasteur, Ltd. 0 MMR (Measles, mumps, and rubella) MMR-II Merck 0 Varicella Varivax Merck 0 1Licensed for persons 7 years of age and older. 2For use in children 15 to 18 months of age. 3Influenza vaccine is recommended for children 6-23 months of age. MMWR (2004) 52:1-4; MMWR (2004) 53:1-3.

OCR for page 185
Immunization Safety Review: Vaccines and Autism TABLE C-2 Mercury Content from Thimerosal in the Currently Licensed Vaccines That Are Recommended for Some Children in the United States, April 2004 Vaccine Brand Name Manufacturer Hg [μg/dose] DT (Diphtheria and tetanus toxoids) All Products Aventis Pasteur, Inc. (single dose) 0.3   Aventis Pasteur, Inc. (multi-dose) 25   Aventis Pasteur, Ltd* 25 TT (Tetanus Toxoid) All Products Aventis Pasteur, Inc. 25 Pneumococcal Polysaccharide Pneumovax 23 Merck 0 Hepatitis A Havrix Glaxo-SmithKline 0 Vaqta Merck 0 Influenza Fluzone1 Aventis Pasteur, Inc. 25 Fluzone (Preservative free) Aventis Pasteur, Inc. ≤1 μg/0.5 mL dose or ≤0.5 μg/ 0.25 mL dose Fluvirin Evans 25 Fluvirin Evans <1 μg Influenza, Live FluMist MedImmune 0 *Not available in the United States. 1Children under 3 years of age received half of a vaccine dose (0.25 mL or 12.5 μg mercury/dose).

OCR for page 186
Immunization Safety Review: Vaccines and Autism TABLE C-3 Mercury Content from Thimerosal in Other Licensed Vaccines in the United States, April 2004 Vaccine Brand Name Manufacturer Hg [μg/dose] Anthrax BioThrax BioPort Corporation 0 Smallpox Dryvax Wyeth 0 BCG*   Organon Tecknika 0 Mycobax Aventis Pasteur, Ltd 0 Hepatitis A-Hepatitis B Twinrix Glaxo-SmithKline <1 μg Hepatitis B Engerix B (adult formulation) Glaxo-SmithKline < 0.5   Recombivax HB (adult formulation) Merck 25   Recombivax HB (adult formulation) Merck 0 Lyme* LYMErix Glaxo-SmithKline 0 Meningococcal1 Menomune A, C, AC and A/C/Y/W-135 Aventis Pasteur, Inc. (multidose) 25   Single dose 0 Rabies IMOVAX Aventis Pasteur SA 0 Rabavert Chiron Behring 0 Typhoid Fever Typhim Vi Aventis Pasteur SA 0 Vivotif Berna Berna Biotech, Ltd. 0 Yellow Fever YF-VAX Aventis Pasteur, Inc. 0 Japanese Encephalitis Vaccine JE-VAX Aventis Pasteur, Inc. 35 *Not available in the United States. 1Menomune A/C/Y/W-135, a thimerosal-containing vaccine, is not indicated for infants and children younger than 2 years of age except as short-term protection of infants 3 months and older against Group A. (Physician’s Desk Reference, 2001).

Representative terms from entire chapter:

influenzae type