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Immunization Safety Review: Vaccines and Autism
Appendix C
Thimerosal Content in Licensed Vaccines (Adapted from FDA, 2003, 2004)
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Immunization Safety Review: Vaccines and Autism
TABLE C-1 Mercury Content from Thimerosal in the Routinely Recommended Pediatric Vaccines1 in the United States, April 2004
Vaccine
Brand Name
Manufacturer
Hg [μg/dose]
DTaP
(Diphtheria and tetanus toxoids and acellular pertussis)
Tripedia
Aventis Pasteur, Inc.
≤0.3
Infanrix
Glaxo-SmithKline
0
Daptacel
Aventis Pasteur, Ltd
0
Td1
(Tetanus and diphtheria toxoids)
None
Aventis Pasteur, Inc.
25
Decavac
Aventis Pasteur, Inc.
= 0.3
None
Aventis Pasteur, Ltd
0
None
Mass Public Health
8.3
DTaP-Hib
(Diphtheria and tetanus toxoids with acellular pertussis combined with Haemophilus influenzae type b)
TriHIBit2
Aventis Pasteur
≤0.3
Hib
(Haemophilus influenzae type b)
ActHIB/OmniHib
Aventis Pasteur, SA
0
HibTITER (Single dose)
Wyeth-Lederle
0
PedvaxHIB liquid
Merck
0
Hib/HepB (Haemophilus influenzae type b combined with Hepatitis B )
COMVAX
Merck
0
Hep B
(Hepatitis B)
(pediatric formulation)
Engerix B
Glaxo-SmithKline
<0.5
Recombivax HB
Merck
0
Influenza
Fluzone3
Aventis Pasteur, Inc.
12.5
Fluzone
Aventis Pasteur, Inc.
≤0.5ug/
(Preservative Free)
0.25mL dose
Pneumococcal
Prevnar
(pneumoconjugate)
Wyeth
0
IPV
(Inactivated polio vaccine)
IPOL
Aventis Pasteur, SA
0
Poliovax
Aventis Pasteur, Ltd.
0
MMR
(Measles, mumps, and rubella)
MMR-II
Merck
0
Varicella
Varivax
Merck
0
1Licensed for persons 7 years of age and older.
2For use in children 15 to 18 months of age.
3Influenza vaccine is recommended for children 6-23 months of age. MMWR (2004) 52:1-4; MMWR (2004) 53:1-3.
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Immunization Safety Review: Vaccines and Autism
TABLE C-2 Mercury Content from Thimerosal in the Currently Licensed Vaccines That Are Recommended for Some Children in the United States, April 2004
Vaccine
Brand Name
Manufacturer
Hg [μg/dose]
DT
(Diphtheria and tetanus toxoids)
All Products
Aventis Pasteur, Inc. (single dose)
0.3
Aventis Pasteur, Inc. (multi-dose)
25
Aventis Pasteur, Ltd*
25
TT (Tetanus Toxoid)
All Products
Aventis Pasteur, Inc.
25
Pneumococcal Polysaccharide
Pneumovax 23
Merck
0
Hepatitis A
Havrix
Glaxo-SmithKline
0
Vaqta
Merck
0
Influenza
Fluzone1
Aventis Pasteur, Inc.
25
Fluzone
(Preservative free)
Aventis Pasteur, Inc.
≤1 μg/0.5 mL
dose or ≤0.5 μg/
0.25 mL dose
Fluvirin
Evans
25
Fluvirin
Evans
<1 μg
Influenza, Live
FluMist
MedImmune
0
*Not available in the United States.
1Children under 3 years of age received half of a vaccine dose (0.25 mL or 12.5 μg mercury/dose).
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Immunization Safety Review: Vaccines and Autism
TABLE C-3 Mercury Content from Thimerosal in Other Licensed Vaccines in the United States, April 2004
Vaccine
Brand Name
Manufacturer
Hg [μg/dose]
Anthrax
BioThrax
BioPort Corporation
0
Smallpox
Dryvax
Wyeth
0
BCG*
Organon Tecknika
0
Mycobax
Aventis Pasteur, Ltd
0
Hepatitis A-Hepatitis B
Twinrix
Glaxo-SmithKline
<1 μg
Hepatitis B
Engerix B
(adult formulation)
Glaxo-SmithKline
< 0.5
Recombivax HB
(adult formulation)
Merck
25
Recombivax HB
(adult formulation)
Merck
0
Lyme*
LYMErix
Glaxo-SmithKline
0
Meningococcal1
Menomune A, C,
AC and A/C/Y/W-135
Aventis Pasteur, Inc.
(multidose)
25
Single dose
0
Rabies
IMOVAX
Aventis Pasteur SA
0
Rabavert
Chiron Behring
0
Typhoid Fever
Typhim Vi
Aventis Pasteur SA
0
Vivotif Berna
Berna Biotech, Ltd.
0
Yellow Fever
YF-VAX
Aventis Pasteur, Inc.
0
Japanese Encephalitis Vaccine
JE-VAX
Aventis Pasteur, Inc.
35
*Not available in the United States.
1Menomune A/C/Y/W-135, a thimerosal-containing vaccine, is not indicated for infants and children younger than 2 years of age except as short-term protection of infants 3 months and older against Group A. (Physician’s Desk Reference, 2001).
Representative terms from entire chapter:
influenzae type