Appendix A
Pandemic Influenza: Assessing Capabilities for Prevention and Response

June 16–June 17, 2004

The National Academies

Lecture Room

2101 Constitution Avenue, NW (C Street Entrance)

Washington, D.C.

AGENDA

Wednesday, June 16, 2004

8:00

Continental Breakfast

8:30

Welcome and Opening Remarks

Adel Mahmoud, MD, PhD

Chair, Forum on Microbial Threats

President, Merck Vaccines

8:35

Keynote Address: John M. Barry, Distinguished Visiting Scholar, The Center for Bioenvironmental Research at Tulane and Xavier Universities, and author of The Great Influenza: The Epic Story of the Deadliest Plague in History



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The Threat of Pandemic Influenza: Are We Ready? - Workshop Summary Appendix A Pandemic Influenza: Assessing Capabilities for Prevention and Response June 16–June 17, 2004 The National Academies Lecture Room 2101 Constitution Avenue, NW (C Street Entrance) Washington, D.C. AGENDA Wednesday, June 16, 2004 8:00 Continental Breakfast 8:30 Welcome and Opening Remarks Adel Mahmoud, MD, PhD Chair, Forum on Microbial Threats President, Merck Vaccines 8:35 Keynote Address: John M. Barry, Distinguished Visiting Scholar, The Center for Bioenvironmental Research at Tulane and Xavier Universities, and author of The Great Influenza: The Epic Story of the Deadliest Plague in History

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The Threat of Pandemic Influenza: Are We Ready? - Workshop Summary PLANNING AND PREPAREDNESS FOR PANDEMIC INFLUENZA Session I: Global and National Preparedness Strategies Moderator: Adel Mahmoud, MD, PhD, Chair, Forum on Microbial Threats/President, Merck Vaccines 9:05–9:35 WHO: Priority Public Health Interventions Before and During an Influenza Pandemic Klaus Stöhr, DVM, Project Leader, Global Influenza Programme, Department of Communicable Disease Surveillance and Response, World Health Organization, Geneva 9:35–10:05 U.S. Government Pandemic Influenza Preparedness Plan Bruce Gellin, MD, Director, National Vaccine Program Office, U.S. Department of Health and Human Services 10:05 Q&A/Open Discussion 10:30 Break Session II: Response and Discussion of Preparedness Planning Moderator: Stanley Lemon, MD, Vice Chair, Forum on Microbial Threats and Dean of Medicine, The University of Texas Medical Branch at Galveston 10:45 Discussion Panel: David Fedson, MD, Sergy Haut, France Nancy J. Cox, PhD, Chief, Influenza Branch, CDC and Director, WHO Collaborating Centre for Surveillance, Epidemiology and Control of Influenza Dennis Perrotta, PhD, State Epidemiologist, Texas Peter A. Shult, PhD, Director, Communicable Disease Division and Emergency Laboratory Response, Wisconsin State Laboratory of Hygiene 11:15 Open Discussion 12:00 Lunch

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The Threat of Pandemic Influenza: Are We Ready? - Workshop Summary Session III: Obstacles and Opportunities for Optimal Preparedness Moderator: Gary Roselle, MD, Program Director for Infectious Diseases, Department of Veterans Affairs Central Office 1:00–1:20 Partnering with the Private Medical System Gordon Grundy, MD, Regional Medical Director, Aetna Inc. 1:20–1:35 Discussion 1:35–1:55 Vaccine Development and Production Issues Philip Hosbach, Vice President of New Products and Immunization Policy, Aventis Pasteur SA 1:55–2:10 Discussion 2:10–2:30 Ensuring an Adequate Stockpile of Antivirals Paul Brown, PhD, Global Task Force Leader for Tamiflu™ Pandemic Planning, F. Hoffmann La-Roche, Switzerland 2:30–2:45 Discussion 2:45–3:05 Chasing the Elusive Virus: Preparing for the Future by Examining the Past Jeffery K. Taubenberger, MD, PhD, Chair, Department of Molecular Pathology, Armed Forces Institute of Pathology, U.S. Department of Defense 3:05–3:20 Discussion 3:20 Break Session IV: Panel Discussion—Innovating Past Barriers Moderator: Joshua Lederberg, PhD, Nobel Laureate, Sackler Foundation Scholar, Rockefeller University 3:30–3:45 Strategies for Control of Influenza by Targeting Broadly Conserved Viral Features Suzanne Epstein, PhD, Center for Biologics Evaluation and Research, Food and Drug Administration 3:45–4:10 Mathematical Modeling: Containing Pandemic Influenza with Vaccines and Antivirals Ira Longini, MD, Rollins School of Public Health, Emory University, Atlanta, GA March Lipsitch, PhD, Harvard School of Public Health, Boston, MA

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The Threat of Pandemic Influenza: Are We Ready? - Workshop Summary 4:10–4:25 “Insuring” for a Better Response Martin Meltzer, PhD, National Center for Infectious Diseases, U.S. Centers for Disease Control and Prevention 4:25–4:40 Coordination Between the Public and Private Sectors Jonathan B. Perlin, MD, PhD, MSHA, FACP, Acting Under Secretary for Health, Department of Veterans Affairs 4:40–5:30 Q&A/Open Discussion 5:30 Adjournment of the First Day Thursday, June 17, 2004 BATTLING NATURE’S TERRORIST: SCIENTIFIC AND PUBLIC HEALTH TOOLS 8:00 Continental Breakfast 8:30 Opening Remarks/Summary of Day 1 Stanley Lemon, MD Vice Chair, Forum on Emerging Infections Session V: Methods for the Prevention and Containment of Pandemic Influenza Moderator: Carole Heilman, PhD, Director, Division of Microbiology and Infectious Diseases, NIAID, NIH 8:45–9:15 A Report from the Field: The 2003–2004 H5N1 Outbreak Robert Webster, PhD, Rose Marie Thomas Professor and Chair, Department of Infectious Diseases, St. Jude’s Children’s Research Hospital, Memphis, TN 9:15–10:15 Discussion Panel: Amin Soebandrio, MD, PhD, Assistant Deputy Minister for Research and Technology for Health and Medical Sciences, Indonesia Nguyen Tien Dzung, DVM, PhD, Head of Virology, National Institute for Veterinary Research, Ministry of Agriculture and Rural Health Development, Vietnam

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The Threat of Pandemic Influenza: Are We Ready? - Workshop Summary   Chantanee Buranathai, DVM, PhD, Chief, Emerging and Exotic Animal Disease Section, Division of Veterinary Epidemiology, Department of Livestock Development, Thailand 10:15–10:40 Strategies for Preventing and Controlling Avian Influenza and its Transmission within the Bird and Animal Population Dewan Sibartie, DVM, PhD, Scientific and Technical Department, Office International des Épizooties (OIE) 10:40–11:45 Discussion Panel: Guus Koch, DVM, Central Institute for Animal Disease Control, Wageningen University and Research Centre, Lelystad, The Netherlands David Swayne, DVM, PhD, Laboratory Director and Research Leader, Southeast Poultry Research Laboratory, U.S. Department of Agriculture Carol Cardona, DVM, PhD, Poultry Extension Veterinarian and Assistant Professor, Veterinary Extension, University of California-Davis Laurence S. Tiley, PhD, Lecturer in Molecular Virology, Centre for Veterinary Science, University of Cambridge, United Kingdom 11:45 Break 12:00–12:25 Enhancing Influenza Surveillance: From the Global to the Local Perspective Nancy J. Cox, PhD, Chief, Influenza Branch, Centers for Disease Control and Prevention and Director, WHO Collaborating Centre for Surveillance, Epidemiology and Control of Influenza 12:25–1:00 Discussion 1:00 Lunch Session VI: Panel Discussion—Priorities for Improving Preparedness Moderator: Frederick Sparling, MD, Professor of Medicine, Microbiology, and Immunology, University of North Carolina

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The Threat of Pandemic Influenza: Are We Ready? - Workshop Summary 2:00–2:20 Pandemic Influenza and Mortality: Past Evidence and Projections for the Future Lone Simonsen, PhD, Office of Global Affairs, National Institute of Allergy and Infectious Diseases, National Institutes of Health 2:20–2:40 Increasing Awareness and Uptake of Influenza Immunization Glen Nowak, PhD, Office of Health Communications, National Immunization Program, CDC 2:40–3:00 Public Communication Strategies to Remedy Panic in a Pandemic Monica Schoch-Spana, PhD, Center for Biosecurity, University of Pittsburgh Medical Center 3:00–3:20 Preparing the Legal System for Pandemic Influenza Larry Gostin, JD, Center on Law and the Public’s Health, Georgetown University 3:20 Open Discussion 5:00 Closing Remarks/Adjourn DISCUSSANTS-AT-LARGE David Bell, MD, Senior Medical Officer, Office of the Director, National Center for Infectious Diseases, Centers for Disease Control and Prevention Timothy Booth, MD, Director, Viral Diseases Division, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, Winnipeg, Ontario Kathy Coelingh, PhD, Senior Director of Scientific and Regulatory Affairs, MedImmune Vaccines, Mountain View, CA Jack Croddy, Senior Advisor, Office of Diplomacy, U.S. Department of State William M. Egan, PhD, Acting Director, Office of Vaccines, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration Geoffrey Evans, MD, Medical Officer, Vaccine Injury Compensation Program, Health Resources and Services Administration, U.S. Department of Health and Human Services Harold Foster, Deputy Director, Office of International Health Affairs, U.S. Department of State Adolfo Garcia–Sastre, PhD, Associate Professor, Department of Microbiology, Mount Sinai School of Medicine, New York

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The Threat of Pandemic Influenza: Are We Ready? - Workshop Summary Kathleen F. Gensheimer, MD, MPH, State Epidemiologist and Director, Medical Epidemiology Section, Maine Bureau of Health, Department of Human Services Robert A. Heckert, DVM, PhD, National Program Leader, Animal Health, Agricultural Research Service, U.S. Department of Agriculture Charles Hoke, MD, Walter Reed Army Institute of Research, U.S. Army Medical Research and Materiel Command Yanzhong Huang, PhD, Assistant Professor and Director, Center for Global Health Studies, John C. Whitehead School of Diplomacy and International Relations, Seton Hall University Dominick Iacuzio, F. Hoffman La-Roche George Kemble, PhD, Senior Director of Research, MedImmune Vaccines, Mountain View, CA Richard F. Kingham, JD, Partner, Covington and Burling, Washington, DC, and London David J. Lipman, MD, Director, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Nina Marano, DVM, MPH, Dipl. ACVPM, Associate Director for Veterinary Medicine and Public Health National Center for Infectious Diseases, Centers for Disease Control and Prevention James T. Matthews, PhD, Director, External Research and Development, Aventis Pasteur Group, Swiftwater, PA Michael McGuire, F. Hoffman La-Roche Mark Miller, MD, Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health Arnold Monto, MD, Professor of Epidemiology, Director of the University of Michigan Bioterrorism Preparedness Initiative, School of Public Health, University of Michigan, Ann Arbor Stuart Nightingale, MD, Senior Advisor, Office of the Assistant Secretary for Public Health Emergency Preparedness, U.S. Department of Health and Human Services Tara O’Toole, MD, MPH, Center for Biosecurity, University of Pittsburgh Medical Center Michael Perdue, PhD, Research Leader, Environmental Microbial Safety Laboratory, Animal & Natural Resources Institute, Agricultural Research Service, U.S. Department of Agriculture Sara Radcliffe, MPH, Director, Science Policy and Bioethics, Biotechnology Industry Organization

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The Threat of Pandemic Influenza: Are We Ready? - Workshop Summary Stewart Simonson, Assistant Secretary for Public Health Emergency Preparedness, Office of Public Health Emergency Preparedness, U.S. Department of Health and Human Services Eve Slater, MD, former Assistant Secretary for Health, U.S. Department of Health and Human Services Rick Smith, MD, Office of Special Programs, Healthcare Emergency Preparedness, Health Resources and Services Administration, U.S. Department of Health and Human Services Kanta Subbarao, MD, Senior Investigator, Respiratory Viruses Section, National Institute for Allergy and Infectious Diseases, National Institutes of Health Susan C. Trock, DVM, MPH, DACVPM (Epi), New York State Department of Agriculture and Markets Clara Witt, VMD, MPH, Global Emerging Infections Surveillance System, U.S. Department of Defense