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Making Better Drugs for Children with Cancer
TABLE 4 Commonly Used Agents for Primary Treatment of Childhood Cancers
Drug
Original Approval Date of NCE1
Approved Use2
Pediatric Dosage3
Pediatric Uses and Administration, or Indication4
arsenic trioxide
2000
APL
NHL, APL
Yes (but limited)
L-asparaginase
1983 or earlier
ALL
ALL, LL
Yes
bleomycin
7/31/73
Testicular cancer, lymphomas, squamous cell carcinomas (various), malignant pleural effusions
HL, germ cell tumors
No
carboplatin
3/3/89
Ovarian cancer
Osteosarcoma, neuroblastoma, retinoblastoma
No
cisplatin
7/16/99
Testicular/ovarian tumors, bladder cancer
Osteosarcoma, neuroblastoma, CNS tumors
No
cyclophosphamide
7/3/86
Many types of cancer
Osteosarcoma, NHL, ALL, neuroblastoma, HL
Yes
cytarabine
Before 1/1/82
Lymphomatous meningitis
AML, ALL, NHL
No
dactinomycin
Before 1/1/82
Many childhood cancers and some cancers of adulthood
Wilms’ tumor, Ewing’s sarcoma, rhabdomyosarcoma, testicular carcinoma, osteosarcoma, neuroblastoma, germ cell neoplasms, melanoma
Yes
daunorubicin HCl
6/23/98
ALL
NHL, AML, LL, ALL, HL
Yes
doxorubicin
Before 1/1/82
Many types of cancer
NHL, Wilms’ tumor, neuroblastoma, osteosarcoma, Ewing’s sarcoma, germ cell neoplasms, carcinomas, hepatoblastomas, hepatocellular carcinomas
No dosage
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