TABLE 7-3 Risk Estimates for Cancer Incidence and Mortality from Studies of Radiation Exposure: Female Breast Cancer

Reference

Study

Radiation Type

Average Dose (Gy)

Dose Range

Cases

Controls/Population

ERR per Gy

LB

UB

EAR/104 PY/Gy

LB

UB

Comments

Incidence

Boice and others (1988)

Cervix

External + 226Ra

0.3

 

953

1,806

−0.20

<−0.2,

0.3

 

Overall

 

145

284

0.33

<−0.3,

5.8

Women with no ovaries

Hildreth and others (1989)

Thymus

 

0.69

[0.02–7.5]a

22

1,201

2.48

1.1

5.2

5.7

2.9,

9.5

 

Boice and others (1991b)

Fluoroscopy

External

0.79

[0.02–5]a

147

2,573

0.61

0.3

1.01

10.7

6.0

15.8

Overall

 

1.00

 

Exposure at age 15

 

0.70

Exposure at age 25

0.10

Exposure at age 35

Mattsson and others (1995)

Benign breast disease

External

5.8

0–50

47

 

1.63

0.77

2.89

 

Shore and others (1986)

Postpartum mastitis

External

3.8

[0.6–14]a

51

601

0.40

0.2

0.7

Lundell and others (1996)

Hemangioma

Mostly 226Ra

0.39

<0.01–5.8

75

9,675

0.38

0.09

0.85

0.4

 

 

Overall 50+ years after exposure

0.22

 

16

 

2.25

0.59

5.62

22.9

 

 

Lundell and others (1999)

Hemangioma

Mostly 226Ra

0.29

<0.01–35.8

236

17,202

0.35

0.18

0.59

0.7

0.4

1.1

 

Travis and others (2002)

HD survivors

External

22

<0.1–61.3

67

122

0.15

0.04

0.73

 

Women with chest radio-therapy only

Mortality

Weiss and others (1994)

Ankylosing spondylitis

External

0.59

0.07–1.27

42

 

0.08

−0.3,

0.65

NA

NA

Note—high dose to the ovary

Howe and others (1996)

Fluoroscopy

External

2.13

0–18.4

103

 

3.56

1.85

6.82

10.3

6.4

16.2

Nova Scotia: for exposures at age 15—EAR 20 years after exposures

 

0.79

0–14.4

578

 

0.40

0.13

0.77

1.2

0.4

2.3

Other provinces: for exposures at age 15—EAR 20 years after exposures

 

681

 

0.90

NA

3.2

 

Overall: for exposures at age 15—EAR 20 years after exposures

Doody and others (2000)

Scoliosis

External

0.11

0–1.7

70

4,942

2.7

−0.2

9.3

 

Among women with at least one radiographic examination

NOTE: The number of cases and controls (or population size in cohort studies) as well as the mean dose and range relate only to exposed persons. Empty cells indicate data not available from publication. LB = lower bound; UB = upper bound of CI.

aFrom Preston and others 2002.



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