Cover Image

PAPERBACK
$26.00



View/Hide Left Panel
Click for next page ( 8


The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement



Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.

OCR for page 7
~~ 1 ~ 71~t ;~7~i} ~J ~1 1 ~ 71~ ~4 ~~ Institutional Policies and Responsibilities OUT A1~ =4 Scholl ^~e ~~ I Am, AM 4 1~ ~ ~ ( If ~ *~ Aim ) ~ BLAT ~ Berm ~ ~ ~~ At~ O~TtAl~ ~* } Troll arm ~~ ~21* I wi! 34~oln1 76~1 ~~o1 p - Aft al iSflA1 .] Id, jowly ~~ ~E] 94 ~ol1 ~0 71~ ~~ Tame al Awry Tom 0~ ~ 71~ ~ rivals I ~_~1~ (Animal Welfare Regulation. AWRs. CFR. 1985) up r~O4~ 1~ best At~r ~~ o~$1A.9~;~? (PHS Policy, PHS 1996)~ ~ ze~ 1~. T. 7'1~ I ~748lQ] no AM =~7~ Tams 7il~040t 2~ Y 7|~AlqA1 Thyme At, ~7~~ TiSa ~71 $1 'flat ~ *EWE] =4 Aig ~ ~ 7 ~~ 7~~M ~ 7~ T I r71tttR *~1AT - 191:I(IACUC: institutional Animal Care and Use Committee) ~ ~ blot Ad. al =25!~905!| 74=o ~~240fl 70~01 .471~ ~~* ~~ Splat ~ ~ -errs Q 01709~8 7~7~7t =~2J~ 4!~ ~1~91~ r3 e Moon Air! 1~fl ARE ii7$~ Tile ~8~ 7^~-O3 0170a~-e ~ US o1~S!] T121At7t Al IDES ~ Ot in' 7~\ 71 :etQ ~ ~~ (IACUC)~ Ago 71 ~ Q ~ ~-O~r3, 7~ 04 ~ 71 ~ Jag ~r 1q!lQ COOSotc~ot ~ ~lo1 Ape. 1. Art THAI (Monitoring the Care and Use of Animals) 1-l 7j~LII ~ti~CtalAI~$1!~!i~7 (Institutional Animal Care and Use Committee) 7 71~94 ~70~^77D~71-e 4!lil27(1ACUC)~ ~ei~Al ~0~ I, al ~~ -lot ~ 7~DAlQ1 ollF~7^1;~D(AWRS)~ '~7~ o~$1Ao~70#7(PHS Policy) oflA1 Hi| Al c ~ ~ ~ 71 ~ En Al 91 To ~ hit Zl By AHAB ~ ~ ~ ill, ~ ~ Be 7~$ A| ^e O | ~ S ~ ~ 2 7^13t 7D[70~ r.S7l.~, 74 71~4: $1~~ ~3Inn 7~79~ og~$ 714 7 (background materials) Ooze 7~7e~ 1~7^~Q, Afl~-o~t-oiri Amid 70T $1 27O~ 3r]4Pd ~7~1~ 93~o1 0l29o-= ~7~ T Alp ~ Trod ~~ 49-~ To-do|| 711 '=;~ ii'$pQ ~A1 R ~ ~~ I Tat ^~ ~ D ~ 7a At. O ~~I ~~ <^1~ TSt]At U OCR for page 7
in ~~ ~~ ^~ ~~ ~1'J 71 ~~ ~ ~ ~ ~ . 1 D . $ D ~ ~ O ~ D ~ 1l ~ ~ ~ ~ T ~ ~ I *. $~11~1 Wool| ~~ ~~ rO~$1~a~] ~ r~=iCl~J all 81 +~ 1~. !q~ ~~ Ate =~ ~ ~ ~~ ~ 7~17~D~l al al Cl At, ~ ~ ~ ~ 71 o ~ ~$~ O ^1~ CAN O _ ~ ~ ~ ~ ~~ ~ ~ ~ ~~ ~ at Ian ~A1 ~1~ O ~~ If. ^1~. ~$ All ~~ Ail M~ O ~tt~ 98~1 ~1~ ~71T~ + ~1* ~ ~71 ~ ~ 67R~o' ~ ~ +~t ~, o~ 7~ 71~ ~71. ~. ~ *~Ai$ Al~ A1~ ~At8 _~ ~D~ ~1~ 67R~ ~ ~ R} ~. ~D~ ~At ~ ~ o1 8~ ^1 ~o ~ql ~q A~ ~ ~ ~ ~D~ 04 ~ ^1 ~D qlA1 ~ ~ ~ ~ At l cR ~ ~^o~ ~ ~ A1 ~ ~~ ~ OD 7:ql 711 7'11 ~] ) ~. 1 ~ MA1 ql ~ ~ A1 ~D A1 ~ 0~ ~. T . ~ . ^1 ~ ~ ~ D ~ 70 ~ ~ ~ ~ ~ ~ ~ At~ _ ~ D ~ ~ER 7t v~4!401c~t ~q w~eS~o Fo~iqAS~iO~i~ rAle=3, ~T. ~$ql At~1= ~T ol~ ~q' cR~ rl~O~T~J (IRAC. 1985: T~ D i=~) = . 1 D 1 n ~ 73 Olo] 7D ~ lsR t ~ 1-2 ~aI^H~ ~ (Animal Care and Use Protocols) ~3~ D~ A~ ~ ~ ~ ~ ~1 ~ ~ ~D ~~. 641 0] 04 ~R ~ Ai~ e ~ ~ oi 4 Ot ~. v |~ ~I~o~ ~r~131 ~lT~ ~ o;; ...7~94 ~^o(7~r8P~ ~!Zl T~ ~ *7il84 711!~r~o ~ l(lessinvasive procedures), ~ ~ ~1~}71 l. ~R J. ~. ~D~r~ ~A17D~ ~*^ol~ ~o(~ A rc8Al~ ~4~) ~ ~S 7.1 S!1 ~ i~ S} 0 D ~ =~4t m71(housing) =~ ^~$;~71o1 ~ ol~ Z] ~ 7!78 . ~ ~. 1 ~1 ( ~ ~ ~77 ;~ it1 ~21 ~r~ =~ 704 gR ~r D~ ,i' ~ 1!rl ~. T~ A r~4!1 ~ 54~:~ Al-1 ~ ) O Ye ~e ~ ~ ~Y=~ ~D O rT521 ~ ~ ~ T~ e D O A1 71 ~ 7~ i=~= ~7~ S: 3~70 ~]Tq' ~ i~ ~AtS!| ~A1 . ~ ~^itl 71 ~ ~1 ~ 7~._ ~e~7t lI^J~e 70 $ 0~4At2t ~ i~.. 71~ ~ ~e~ ~1 ~1 T ;(t E] ;S:| oJi~4Al 51 ~1 B1 ~ D O ~T7~1~ $1~ ;~40D43~705!l oJ75 o 22

OCR for page 7
~ 1 ~ 71~0 ~~ Cod 01~71 ^]A15| ;g ~71~ ~711 3:~e~t T 01~ Whole ~IEDII^~ Tamp' Film X~ ~ 7JX o1~. olEl~ Toll. ~~ ~701. ~T54 C~8 MA iJil ilk ~ .-- ant. ~~l(adiuvant)At. ~~ ~ ~D01l Tame 7~ Q 8~=/g ;~= ~~ }fitly) MULL!| ~= ^1~ . ~~ ~ 0 me!. ~ old ~ ~q (orbitalsinus) ilk D1709~7A ~700~7.1 T4 ol 1~. ol~1~ D~T~lQl ~~o71 =~n ~q~ZY:~7~od 7~=~=]'=~, TSt19. ~-i4~7 Reroll Ulil~O<~:on 41~ 7~| ~ =~ 71' 1 7 ~. ti~ 1 t! ~ ~ 1 (t~. nD1~ D (pilot study)~ 7~o1 ~ f~ ~ D0| ~ 7'11~ 7D ~ 7( T~ oT ~ (IACUC) 7 ~_ o~ql e~oO1 0 F n D| 71 C o.S~o1 .~lot 8~m o4~ ~A gqn ~ ~ 7i ~1 ioo1 ol 70~q4A1 A1F=7 7,1 DJ ~ ~ ~ Qon T~ 7 :iC1 ,_ ~, 1-3 ~ (Physical Restraint) ~ 709 ol ~ o~ O7 ~o ~, ~ ~ ~ ~, O7tF=~, 7.1 ~, Ae ~D +~4 ~Q ~71 ~ ~4 0 F 7 7D~7a1 =02^ 9T l;Fe ~76~1 7`n~ ~ O ~ 1~7 ~a~ 717* ol 7~ ~4 ~. r~ T~7 ~o n ~ ~ ~o7 ~ Q A17~ J -~ ~ ~ O ~. FQ ^111 ~771~ O] ~o1 7,l^1 ~J ~79~ f ~ u7g71 T~ . IQL ,l01 7~ ,7 OFql7~| ~+O7 ^=D4~q ~71~ T~ ~74Q' ~ T il~ Q ~Jt} . NIT~ 711, ~lTr(nonhuman primates: e.g. Reinhardt 1991.1995) ~P7 . ~F. =~~ 2 e ~ ~;~|~ 7~ ~F~4~Q o~ o0,: =~ol~1 ~'; ~ .~. j74 Al -7e f ,,1~. ~ol*= O7i~oll ~8le 7~(monkey chair)~ 7cte 9~1~7 =70a~= ~=Q77^" ~O~In ~e T~7 ol 71 ~71 ~ S] ~1 (IACUC) ;~ TE1 ~1 W=~7~1 ~tt 78 $ 7~1 ~to] # tt~. k=~70Q7~ ~70nol ~ 0BJ 70$ zl~7a ~ITr~ 5.~ ~711-F 7~q ,'1 gol~ 71eg~ - l10l(stallchioll)QI 7ctol i7~88 ~1 7caf^]Z~0l zlifol7~tAll~ 71~ T ~1 _ 7~77 7~41 tteQ A7 7~1 7~ ~,]: 0 i5! ~ 709 8~ ot ~ . ~ e T~ ~ ~Q 7~117~1~ 7~01 =7~71L~ QoQ2O|~ Atigo7 ~o,R,7t ~7~ ~e~70=e s,R,o)DJ 8| - 7D $ ld70971~ At~ot27 _e~ ~7J\I ~7071* AF*iiE~ (Bryant 1980; BYrd 1979: Grandin I99I: McNamee and others 1984: Morton and others 1987: Wakeley and others 1974). ~ ~ ~Q Id 70A ~:41 O^A1 ,QI O7 1~04 ol ~ 0~1 q O =30~il71 70a~779O1 T~o 0 ~: 7JTC7OIA1= ~F O ~81 0~=Q ~0~ ~EP7~4=En ~M O}C~ ~70a~i1= 1i41A1= J ~. O ~7JA|7~Q ~1~moO7 +71Q77 eQ O1T`_ 77^i~7 ^17~0101) ~. O ~70 ~~ o F1 ~7114 ~Alqn7~| 77QO ot~ ~P~o1 5110) ~i~ O ~,~7(1ACUC)e oFo| ~70A $1~ o0J ~ :~i51-~ Aq79~ A|7~t 70 7~ ~ ~709 ~14 0 ~7a_ 1~oi o13ql t;=o~1 Ao7A'A71~ 7e~ool ~tAo~ 7a$ T-91~7'7 ~2171 IT 1, t ~. s~ li ~od {F' ^0~ 7 ool~Qe ~ol~ 7d$ eA179 IF L_ ci T7i 0 ~ 31 2 FOl TOl ot lsJ~ 23

OCR for page 7
'My ~~ ~~ ~~ ~1~' 1-4 ~TI all mica 7-~71 (Multiple Major Surgical Procedures) ~7~0 ~ 7~otO] ~740 - ~A1-7171~ ~7a, A]~7~ 71~ 74~ T~= H ~71* If. 7~ 7H~o~731 ~A1~= 7~ 71~ ^10~ A - 7't 7a o ~ ~OroM71~ If ~J~ 70$ - A1~ TO CAT. H~ ~ ]. 7~71 oJ+~7all1 ~~ ~HJ 70$4 ~~J 70$ (NRC 1990, 74T 2~) = ~ Dew Olaf ~ 9~ 70$ m+~ CHIN ~7~ ~ A17l H~. ITS CHOW 91~7~ ;8A17t ~]~! 70$, ~l(!~l(lACUC)~ 0,~:~7~ ~1~7m0~ AMMAN at ~ 7'1 011 ~~ ~ MA 2 7~74 t ~~ '31 ~ 7D~ o] ,Q' ~ ~ TO ~ ~ ~ ~ ~~ rat Al ~ ~A| only : i_ 7~ ~~ At71 !471 ~~JT4(AWRs). 1-5 ^12 CF~ ~T91 Iffy (Food or Fluid Restriction) .g~ssAo} At~5!t ~+54 A|| Sol ~ A 70 $*5 old ~94 ~$~ Id ~91 ~7 7k~ =~71~ $10RA1 i O =BR! eJ~ J+~'7=A] 7`R~o~ 70$ ;~7A 0 is ~ rO~o|o~ Okra clef i, 7j]A] OR Sty ~ ~ ~ 'I e MOORS? l=7D\~ ~T78 l; Q} 72.8 oElA1 fat ~~71fF Z=AltiRot ~~ ens ARC A=5!1A1 72a+ 72A Me eAI 790;2 ~~ o5~31 7Jl~AI72 T ale ~q71-71~ AJ7peRt tt~(Van Sluyters and Oberdorferl991) 781~ 7~* =1~ ~~ eo1AA~3,20qn ARM Bale ~~ Jan. ~~ ~~u 741AJ~. ~ DJAO ~f02 ~of7J~71 Viola oboe f~4q 20~2= 71e cacao' eta,, 7~35- 022 mO2'q1 ~ ~~ iS1~71~r2 (NIL 1990)(~271~QI 72~8 ~ ~1 70$ ~1 71- T If). fief Ala||, Al.iQ~2~30l 771-~! ~~ -I ~~7J~ Atom 3A~2Rot ~ `~(NYAS 1988). ,]T~7~8 chaos} f ..1~ ~91 ~|~J ~RofnJ JO ~7,1~.1-At F ol 8~ e D 21 70$ o 70A 7A 70~S}1~ 0 i;! A,) ~ 7t ~ AltrQ~ ~ olol-~ 7,~01 Alto 11It~ ~e479~ AM 3~$8 O]A<}S] 770 ~e8J Sol 74l8J~ 270~ql^1 J~. 2 T01~7 :Eti'l (Veterinary Care) - -5!| 7~70~ER51 IJA1F ~7~ f .1 ,_ 7 7ei5J 4~847 ~E17t It ~ ~Fq97~|| 74| ~ ~ 7.1 ,45 0 I, obey 71 ~~ ON mS) ~ En ~ ED 93 D 7 ~1~ ~ *~21~ ~ ~ E3 5!1 pal at* 7~179 7no49 3 as', - 7~79 fQlAIF A~~70AotojO) i81:~t 7~7~01~ 7~o49 fQl^~2 Orgy 73$ ma! Aft Tqn ~~ f 35 ~ 7 yell ~~ ~f7t e o!i] ~ ) ~~ fSLlA>Q} T.-A.I7 J i. O=q1 ~E~A1~ 370~q|A1 Alerts ~2j7 . J5-7 . 34847A] ARIA $10~ fifty 70$01~ 770A 7J~781 014177~ ~~ql731 ^~o4t (TV A mu). 797~ Ate 77678~ Oo}5-U~ =4~+S&l^~ O|5.7=Olra :46477aoJ ~J~s1 OIT017.2 f >015_E4 olTAtq 71 ~J~ oRot Ark rem ~ 71 ~ D ~ ~ ro=$1oa~70AYA,J age, +54At71 DISH DISK Atg54 o961 =~^nJol 01 1 Ad =L 76 ~A,] I 71~ ~ f ,,|= inter 7~ at thrill TO ~ lL ,1~ ~~ ~~ At art, Ain't, += era 7~0~. 0.)f3OL~ 7~50-a~03s ~El, *ORES= 7g0Rll Fret 7a~ Ad Q| 7' ~ TO otuL If. 24

OCR for page 7
iq/ 1 ~ 7/~52/ ~11~ ~ .r174 70~D "= ~0~04 7~7eQe .71 TO'707r Or 4 7~ OR e' 2:! OFF . 0~7~ (Occupational Heeith and Safety of Personnel) 7~ 07 ~ 76 OFF 0679 747, ~7 ~ ~ ~ ED A ~~E1 7~ A ~ _ D n ~~ I r (CDC and NIH 1993: CFR 1984a.b,c; PHS Policy). ol 'T~11eD~3_ 21}. T. 'Al~g-~07,l OeilO=I7,O7r=J 67,~ 0~7~ $7tAo7~01 T~70 "has Tr71~rn Te3,~A~07; try CI ;T~!~7DDI7~= 71~ A|~e?4 ~5L~. $1~17't. ~~ql =4E~ ~EFe f IF ~83 8~ ~3 BIAS ~~ reread ~~ Mel ' Armor ~of 7= 0] ~ 7~?4 OJ7~ (Occupational Health and Safety in the Care and Use of Research Animals. NRC 1+q~)~ IEI~ Amp ~~7~01M Jewel. ~1~ =~i==Qs ~4130F 37 TF71 al - tin Me ~ 71 ~ =4 ~ ~ ~~ 01 f _ ~11 >lr] ~ 3747= 1 T ~ ~ ~ 5!1 f ~ =~ 7;~5~7A1 Ba 707 :~1~?4 74 71~54 03~7~0~ 71 ZF~ ~~q1 ~~ JI! F. 714t5!1 71-2F34 25

OCR for page 7
9~, od:j~ =~221(~ ), ~~ ~1~ ~ ~i~l~(f~l~ ) ~ ~ ~ ~ Dim OJ ~ ~ ~ ~ ~ ~ ON, ~ ~ A] ~ | _ . ~ ~ ( I id ~ ~ T . IT A|~ZIT) Sol ~ol 0~. 1Zl~ Oj7~o~ J~q1 ~~ Earl. ~ ~ OD1 'O ~ ID ~ o 1 ~ A| Ma ~ 71 ~ ~ ( ~ ~ ~ D At. I a ~ D ~ ~ T ~ ~ ) ~ ~ ~ ~ ~ e off ~Ljq.ea 1 ~;$ =41 OF ~ ~ ol T ~ ~ ~ ~ By' 4-1 ~rY1~7ie okra E $1~ ~~F (Hazard Identification and Risk Assessment) D ~ a ~a474 5~ 474 ~ ~ 74 1~( o1 ~ ~ ~ 1 o1 ~ 0 o~ ~ e ~ "4) ~ 1 ~F e D ~ e 1 ~ 1 ~ 1771 ~ si D 171~ ~ 7~ f .J ~ 74 7e i,J 0| 73~R 7 ~R~ f 01~ ;~ 7tm~ ~olof ~. ~1 7~0~7~ ~ 0~7;~rp7~ ~ ~ ~ =~ ~ f~7~71 74+A|-7a f ...~ *~ lkit iiz8. 5~ A11~711. a~5lle71 ~7a. ~!f o~ 7~0~ 7~01 ~ J~-R 74~ 1 ^1~ $1~dzfql cR~ 6~03~ ~7~7E olmoi7~4~0t ~. 71781 o~ ~0J7;! ~F 717t 88R~4 ~! $1~ ~7~-~ ~1~ ~D ~;~ f ,,1~ 7;~710ql of ~1 7~ o,0 ~ 7~3 ~ 0~74 ~ e! ~7 ~D ql 0~ ol 08 +7 ~ ~4~ w4 ~ 5~ 7~4 ~ ~ ~ ~e;5T61 - 1~d *~fl17~. tr~704~ `~A|7J 7~f~ 7~q 7no4.~ 71~q =~704- 740D72~^q4A191 ~iR 709~fl ~* =*71~( Clark 1993). 4-2 7~14FJ~L~ (Personnel Trainino) t4 0 _ I t4 . _ A 04 D _ O ~ D 1 7~ ~$' a D 7f ~ ~ 1~ ~ T~ f ~ F ~ fl ~ 1 ~ 401 e o 717il~ ~a~D8R) ~. *g~7a0fl ~A1~ ~71~ i;~:~ ^lolo~ ~ ~a~ ~v ~1* 98~011 'o~f ~w, OJ=o~710D=O. 5~4~7aS!I 0J7.q o r31~a~847~ *iSl12t. ~7m *~fl17t. ^!e~ i~ ~70401 t~l704~7~0~l ~tR~ 0~ (*7,4;(~ 74 ~. u~~tT71~q$AlS] 017J~7~ At *~ o $ ) . fl 1 ~ ~1 ~ . 78 1 $1 a . 71 t] .~7.1 ~ ( OD ^1 7e ~ D1 o t 71 ~ 76 t ) qfl ~ i o4 1;7 4 - D\OtOt tt~ 4-3 7H1$1 OCR for page 7
~11 I ~ 71~ ~33' ~J 71~~ I. USA *= aim Al ^~ ~ 7~ 0 Alit o1 ~ +~ ~ Aim ~~-^ Aged 7R~ Al ~~ ;47dol ^~lEn~, ~~1 Amp ^~ ~ ol 93~71 my:* ~~ o4~4 ~ ~ Rot ~h:f Veldt! tt~9717t 7~ All ~1- ~~ ~i318lot Be. 818~74(Permissible Exposure Limits: PELs)~ ~~ f 1~ :~!~oRA1 xRzqod ~0~84~. ~4~1. - *~17.~ -~ ~71~ f A ol~sRot (CAR 1984b). 4-5 $11~1ff!= ~~ ~1~ (Animal Experimentation Involving Hazards) ~j~l^l.$Aol~ Dim *8R4~!eQ1 I Al+, 4~151 Ted. AR~ ~ ~17l,-~p Al.AR~7l 0~3~ ~ ~~ ~~ ~~2',i~ *art ~$~ ~ Altar IRK J~* Earshot If. ~+ OJ7~4i}U15!l At*3; q7~ ~ 0J7~f al 7=f7~ f~olt t~ 014~ o 2= 7RI~ ~f~ 7~f7~ 7lg ~ S; aim of 71~ Ao~-~4~ ~647~ ~~ ~~ We blow= belt ~2,~71 Weir Alla ~7~ robot Ad. oJ7;1$~ zag 7~ iiR7~ TO1 $1~~-~ J~ FORE at 71~2,}~ m Trot Act. 151~ ~c~sll *c- At*2~ 70$ *~ d'dq824R ~~ bred eE;478 C moot Em. ~1S3CZC~ ga371~= 7~ZcS~ o.b3.~ o,l.~cR~Q T4i8~ d +~!1 ~C?~ OCR for page 7
Aj~L~ ~~ AM I Em. 4-6 aid =~ (Personal Protection) 7RJ ~ ~7~171 ~T017~ Prolog ~~ ~~ 70T ~~ Tam 18~ T Color 71 ~~ ~ ~ ~ ~ ~ ~ Arm ~AJ I a, V. Sol ot Ark. OR I ~1~- 7~05~ ~~, ~1 ~7t ol$01~J ~~ 4~ ARE At$1~ Ot~ 7~01 Em. I ~1~ *89~ ~~ ~ ~ ~~ t$ AIM I ;7 ~.k~iii7'1 oafs rib. *to| ~~ $1 ol ~1~ at * GYM 21 I (CAR 1984c). 01~ Em. Idols ~7~ ~ ~=,R ~~= off ~QrH~ ~~ Mule 7'== 010io~ ,~q ~DQ 7: T ~ 7A ~ ~ - 1~ 7~T04 at Wry 71 ~ -! ~ ~ $1 rA o1 I 71 A ~ 72 T 71 ~Q23~17t (CUR 1984c). 4-7 7~ t1~,~ Aim (Medical Evaluation and Preventive Medicine for Personnel) Z1~7.1 74 @~5!1 I- 'to 7`Q 1:P8~ ~71 2.~7~01 7170~7.~7154 ol~l~i=2 $~ ~;ZZL~ql ~~== 71A. ~O~of d~ Em ~~ YEA. MA al e=l 0.,~, T. 21Uo~ all $1uR=A71 ~~t ~~ 7A~91 ~m^1~ 7097171 7~lql 7R1~1 7,|70~;~D2J(7,!70~71~L 71) ~.4~ol^1 4 AR $1~s -2 ~o7R~ 7101 If. 4 7~21 $1~AT~on OHM 78712~0l A0~7D4A|* 7~01 In, ~ ~ ~ 70$ o0~28~ Ire - 4~7.~ BAJA BAR IRAQ Hand 3 7 o - Q 2 0 0 7 7. 0 0 2 2 It ~ 0 1 14 BE ~ D ~ I 1 n ~~ $] D it 7t 1 ~ ~ ~ T ~ 1 ~ ~ 1 ~ 1 1 J8rq 7604~Q e D A| ARE ~o$~1r c88J Carol overly 21 ~ a ~= 7~01 If. And T~240,1 iH~ CDC~ NIHIlAl ~7~ rOI~a=4~ r4 Al 6T~ Ag~oJ (Biosafety in Microbiological and Biomedical Laboratories, 1993)J at ~t91 1~ 2] 04 ~ 71 4 O]76 28~7~ 79 ~ot, =m TV] 70 TQql JO ~ od ~~ ~ ~~ ~ ~ i2 Alkali: 7901 (NRC JRz). olal~J 70$ Amen ~ Al On T7= D4 Starr' TrQe al R t Sol iR~1Q1 clot IRE TV T~741DD~ rOlill ~~ At~t~ ~ I ~ 0~'3~20Ai~(Federal Policy for the Protection of Human Subjects: Federal Register 56(117):28002-28032. 1991~ 7~ 18e)J 0,3, T~21 ~001 .~r4. OUT O ~~ D ED OR ant ED An ~ D ~ 71 ~~D=q ~D~1t 8~(CDC and NIH 1993: Fox and others 1984: NRC AIR) 2~J~ AJ~D~ AIAe5!1 *7~1 ~ ~OD7l11711 WADER 7170~ - ~17.~ ~eYo3~ 2=IAR2go] ~~ 71~ - ~AtAeQe l 21 ANAL too ~~ ~;~ e ,AA=s~ Idol Mist Sextet. ii7^o~ We| e71 0 t 0 A CROTO] t3 To ~ of 0~ Idol Few T~t (NRC 1~R'). A~2tO,31 A,| 7~D1 7iT-~ To]~rolTr I ~130= DRT ADS ~ *R 17t1r4. e D~71 At OD Ao~~3 JT7'l BEAK OJT~ Id, 7.~, Tr 21 3~ Z3 2~ o I 1 4 D ~ ~~ ~ ~ ^T tat ~ ~ al Or THEA I I He o 1 A1 he eQ of ~ AT ~ ~Q he 63 l rR ~1 ~ ~ E1DOQ2 ~OFO) OJ~. ~1~71~71~(macaoue) ~~ it ~$' e D t~ rD$ Cercopithecine herpes virus 1 (TVS 29 Herpesvirus simiae)-3, 7D;OD 7R=A~ errors oA1 ~171~ my 70$ So ~ 21 al '! ~ .: ~=SRO) ~~ (Holmes and others 1995). ~i7^J~ ~~AOlR IRE 7= Me A1 21 To eQ Bawl ~7R! arm 28

OCR for page 7
he 1 ~ ~ ~ ~r~7~t ~7 J ~1 AVMA (American Veterinary Medical Association). 1995. Accredited Programs in veterinary technology. Pp.236-240 in 1995 AVMA Membership Directory and Resource Manual, 44th ed. Schaumburo, 111.: AVMA. Bryant, J M. 1980 Vest and tethering system to accommodate catheters and a temperature monitor for nonhuman Primates. Lab. Anim. Sci. 30(4,Part 1): 706-708. Byrd, L. D.1979. A tethering system for direct measurement of cardiovascular function in the caged baboon. Am J Physiol 236:H775-H779. CCAC (Canadian Council on Animal Care) 1993. Guide to the Care and Use of Experimental Animals, Vol. 1,2nd ed. E.D. Olfert, B.M. Cross, and A.A. McWilliam,eds. Ontario, Canada: Canadian Council on Animal Care. 211 pp. CDC (Centers for Disease Control and Prevention and NIH (National institutes of Health). 1993. Biosafety in Microbiological and Biomedical Laboratories. 3rd ed. HHS Publication No. (CDC) 93-8395, Washington, D.C.: U.S. Government Printing Office. CDC (Centers for Disease Control and Prevention) and NIH (National Institutes of Health). 1995. Primerv Containment for Biohazards: Selection. Installation and Use of Biological Safety Cabinets. Washington, D.C.: U.S. Government Printing Office. CFR (Code of Federal Regulations). 1984a, Title 10: Part 20, Standards for Pro- tection Against Radiation. Washington, D.C.: Office of the Federal Register. CFR (Code of Federal Regulations). 1984b. Title 29: Part 1910, Occupational Safety and Health Standards; Subpart G. Occupation Health and Environmental Control, and Subpart Z. Toxic and Hazardous Substances. Washington, D.C.: Office of the Federal Register. CFR (Code of Federal Regulations>. 1984c. Title 29: Part 1910, Occupational Safety and Health Standards; Subpart I, Personal Protective Equipment. Washington, D.C.: Office of the Federal Register, CFR (Code of Federal Regulations). 1985. Title 9 (Animals and Animal Products), Subchapter A (Animal Welfare). Washington, D C.: Office of the Federal Register. Clark, J. M. 1993. Planning for safety: biological and chemical hazards. Lab Anim. 22:33-38. Fox, J. G., C. E. Newcomer, and H. Rozmiarek. 1 984. Selected zoonoses and other health hazards. Pp. 614-648 in Laboratory Animal Medicine, J. G. Fox, B. J. Cohen, and F. M. Loew, eds. New York: Academic Press. Grandin, T. 1991. Livestock behavior and the design of livestock handling facilities. PP. 96-125 in Handbook of Facilities Planning. Vol. 2. Laboratory Animal Facilities. New York: Van Nostrand 422 PP. Holmes, G.P.. L-. Chapman, J.A. Stewart, S.E. Strays. J.K. Hilliard. D.S Daven Port & the B Virus Working GrouP.1995. Guidelines for the Prevention and treatment of B-virus infections in exposed persons Clin.lnfect.Dis.20:421-39 IRAC (Interagency Research Animal Committee). 1985.U.S. Government Principles for Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. Federal Register, May 20, 1985. Washington, D.C.:Office of Science and Technology Policy. 29

OCR for page 7
i~_rf ~Z1~ Aloof ~~ Alp Kreser,M D. 1995. Training Materials for Animal Facility Personnel:AWIC Quick Bibliography Series, 95-08. Beltsville, Md.: National Agricultural Library Kruse, R. H., W. H. Puckett, and J. H. Richardson. 1991. Biological safety cabinetry. Clin. Micro. Reviews 4:207-241. McNamee, G. A.. Jr. R. W. Wannemacher, Jr., R. E. Dinterman, H. Roznniarek, and R. D. Montrey. 1984. A surgical procedure and tethering system for chronic blood sampling, infusion, and temperature monitoring in caged nonhuman Primates. Lab. Anim. Sci. 34(3):303-307. Morton, W. R.. G. H. Knitter, P. M. Smith, T. G. Susor, and K. Schmitt. 1987, Alternatives to chronic restraint of nonhuman primates. J. Am. Vet. Med. Assoc.191(10):1282-1286. NIH (National institutes of Health). 1990.Guidelines for Diet Control in Beha- vioral Study Bethesda, Md.: Animal Research Advisory Committee NIP. NRC (National Research Council). 1990. Important laboratory animal resources: selection criteria and funding mechanisms for their Preservation. A report of the institute of Laboratory Animal Resources Committee on Preservation of Laboratory Animal Resources. ILAR News 32(4): A1 A32. NRC (National Research Council).1991. Education and Training in the Care and Use of Laboratory Animals: A Guide for Developing institutional Programs. A report of the institute of Laboratory Animal Resources Committee on Educational Programs in Laboratory Animal Science. Washington, D.C.: National Academy Press. 152 PP. NRC (National Research Council). in Press. Occupational Health and Safety in the Care and Use of Research Animals, A report of the institute of Laboratory Animal Resources Committee on Occupational Safety and Health in Research Animal Facilities. Washington, D.C.: National Academy Press. NYAS (New York Academy of Sciences). 1988. Interdisciplinary principles and Guidelines for the Use of Animals in Research, Testing and Education. New York: New York AcademY of Sciences. PHS (Public Health Service). 1996. Public Health Service Policy on Humane Care and Use of Laboratory Animals. Washington, D.C.: U.S. Department of Health and Human Services. 28 pa. IPL 99-158, Health Research Extension Act, 19851 Reinhardt, V. 1991. Training adult male rhesus monkeys to actively cooperate during in-homecage veniPuncture. Anim. Technol. 42(1):11-17. Reinhardt, V. 1995. Restraint methods of laboratory non-human primates: a critical review. Anim. Welf. 4:221-238. Van Sluvters. R. C., and M. D. Oberdorfer, eds. 1991. Preparation and Maintenance of Higher Mammals During Neuroscience Experiments. Report of National institute of Health Workshop. NIH No. 91-3207. Bethesda, Md.: National institutes of Health. Wakeley, H., J. Dudek, and J. Kruckeberg. 1974. A method for preparing and maintaining rhesus monkeys with chronic venous catheters. Behav. Res. Methods Instrum. 6:329-331. 30