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Suggested Citation:"Front Matter." Institute of Medicine. 2005. John R. La Montagne Memorial Symposium on Pandemic Influenza Research: Meeting Proceedings. Washington, DC: The National Academies Press. doi: 10.17226/11448.
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JOHN R. LA MONTAGNE MEMORIAL SYMPOSIUM ON PANDEMIC INFLUENZA RESEARCH

Meeting Proceedings

Board on Population Health and Public Health Practice

INSTITUTE OF MEDICINE OF THE NATIONAL ACADEMIES

THE NATIONAL ACADEMIES PRESS
Washington, D.C.
www.nap.edu

Suggested Citation:"Front Matter." Institute of Medicine. 2005. John R. La Montagne Memorial Symposium on Pandemic Influenza Research: Meeting Proceedings. Washington, DC: The National Academies Press. doi: 10.17226/11448.
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THE NATIONAL ACADEMIES PRESS
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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.

This study was supported by Contract No. N01-OD-4-2139, Task Order No. 159 between the National Academy of Sciences and the National Institutes of Health. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project.

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Copyright 2005 by the National Academy of Sciences. All rights reserved.

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Suggested Citation:"Front Matter." Institute of Medicine. 2005. John R. La Montagne Memorial Symposium on Pandemic Influenza Research: Meeting Proceedings. Washington, DC: The National Academies Press. doi: 10.17226/11448.
×

“Knowing is not enough; we must apply.

Willing is not enough; we must do.”

Goethe

INSTITUTE OF MEDICINE OF THE NATIONAL ACADEMIES

Adviser to the Nation to Improve Health

Suggested Citation:"Front Matter." Institute of Medicine. 2005. John R. La Montagne Memorial Symposium on Pandemic Influenza Research: Meeting Proceedings. Washington, DC: The National Academies Press. doi: 10.17226/11448.
×

THE NATIONAL ACADEMIES

Advisers to the Nation on Science, Engineering, and Medicine

The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Ralph J. Cicerone is president of the National Academy of Sciences.

The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Wm. A. Wulf is president of the National Academy of Engineering.

The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Harvey V. Fineberg is president of the Institute of Medicine.

The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy’s purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Ralph J. Cicerone and Dr. Wm. A. Wulf are chair and vice chair, respectively, of the National Research Council.

www.national-academies.org

Suggested Citation:"Front Matter." Institute of Medicine. 2005. John R. La Montagne Memorial Symposium on Pandemic Influenza Research: Meeting Proceedings. Washington, DC: The National Academies Press. doi: 10.17226/11448.
×

PLANNING GROUP ON THE JOHN R. LA MONTAGNE MEMORIAL SYMPOSIUM ON PANDEMIC INFLUENZA RESEARCH

RICHARD B. JOHNSTON, M.D., Professor of Pediatrics,

Department of Pediatrics, University of Colorado School of Medicine, Denver, CO

ANN ARVIN, M.D., Lucile Packard Professor of Pediatrics and Microbiology & Immunology,

Stanford University, Stanford, CA

CAROL CARDONA, D.V.M., PH.D., Veterinary Medicine Extension,

University of California, Davis, Davis, CA

PETER PALESE, PH.D., Professor & Chair,

Department of Microbiology, Mount Sinai School of Medicine, New York, NY

STAFF

ROSE MARIE MARTINEZ, Sc.D., Director,

Board on Population Health and Public Health Practice

ALICE WEZI MUNTHALI, M.P.H.

HOPE HARE, M.F.A., Administrative Assistant Consultant

SANDRA HACKMAN, Copy Editor

Suggested Citation:"Front Matter." Institute of Medicine. 2005. John R. La Montagne Memorial Symposium on Pandemic Influenza Research: Meeting Proceedings. Washington, DC: The National Academies Press. doi: 10.17226/11448.
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Suggested Citation:"Front Matter." Institute of Medicine. 2005. John R. La Montagne Memorial Symposium on Pandemic Influenza Research: Meeting Proceedings. Washington, DC: The National Academies Press. doi: 10.17226/11448.
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JOHN R. LAMONTAGNE

1943-2004

This symposium is dedicated to the memory and legacy of John R. LaMontagne, Deputy Director of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health.

As a quiet but tireless champion, he helped to spearhead some of the most important recent global efforts to fight infectious diseases and to improve the health of children and adults everywhere. For nearly 30 years, John’s thoughtful demeanor and even-handed approach led the way in tackling some of nature’s greatest challenges to humankind. His influence has been incalculable on both national and international programs related to the development of vaccines for pertussis, rotavirus, AIDS, influenza, and malaria; new drugs for tuberculosis; and, more recently, biodefense research. In all of his work, John brought the human and public health dimensions to the efforts of laboratory research. He served the nation and the world immeasurably well, and we are better for it.

For the leadership, wise counsel, humor, and friendship that he shared with us and so many others, we are deeply grateful.

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Suggested Citation:"Front Matter." Institute of Medicine. 2005. John R. La Montagne Memorial Symposium on Pandemic Influenza Research: Meeting Proceedings. Washington, DC: The National Academies Press. doi: 10.17226/11448.
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Suggested Citation:"Front Matter." Institute of Medicine. 2005. John R. La Montagne Memorial Symposium on Pandemic Influenza Research: Meeting Proceedings. Washington, DC: The National Academies Press. doi: 10.17226/11448.
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Contents

1

 

INTRODUCTION

 

1

   

 John R. La Montagne Memorial Symposium on Pandemic Influenza Research

 

1

   

 Day 1- April 4, 2005

 

3

   

 Day 2-April 5, 2005

 

4

   

 Meeting Opening Remarks

 

5

   

 Meeting Opening Remarks

 

5

   

 Dr. Harvey Fineberg, President, Institute of Medicine

 

5

2

 

PLENARY SPEAKERS, DAY 1

 

7

   

 Opening Remarks

 

7

   

 The Honorable Michael Leavitt, Secretary of the Department of Health and Human Services

 

7

   

 Meeting Objectives

 

10

   

 Dr. Bruce Gellin, Director, National Vaccine Program Office

 

10

   

 Current Status of Avian Influenza and Pandemic Threat

 

12

   

 Dr. Julie Louise Gerberding, Director, Centers for Disease Control and Prevention

 

12

   

 Plenary Presentation Slides-Dr. Julie Louise Gerberding

 

16

   

 Meeting the Challenge of Pandemic Vaccine Preparedness: An FDA Perspective

 

19

   

 Dr. Jesse Goodman, Director, Center for Biologics Evaluation and Review U.S. Food and Drug Administration

 

19

   

 Plenary Presentation Slides-Dr. Jesse Goodman

 

25

   

 Global Pandemic Preparedness Research Efforts

 

29

   

 Dr. Klaus Stöhr, Project Leader, Global Influenza Programme, World Health Organization

 

29

   

 Plenary Presentation Slides-Dr. Klaus Stöhr

 

35

   

 The Role of NIH Research in Pandemic Influenza Preparedness

 

40

   

 Dr. Anthony S. Fauci, Director, National Institute of Allergy and Infectious Disease, National Institutes of Health

 

40

   

 Plenary Presentation Slides-Dr. Anthony S. Fauci

 

45

3

 

MORNING PLENARY DISCUSSION, DAY 1 (APRIL 4, 2004)

 

53

   

 Moderator: Dr. Harvey Fineberg

 

53

4

 

WORKING GROUPS, DAY 1

 

59

   

Working Group 1  Influenza Virulence and Antigenic Change

 

59

   

 Report to Plenary

 

59

   

 Rapporteur—Dr. Robert Lamb

 

59

   

 Working Group 1 Presentation Slides: Influenza Virulence and Antigenic Change-Dr. Lamb, Rapporteur

 

63

   

 Working Group 1 Briefing Slides: Influenza Virulence and Antigenic Change-Dr. Palese, Briefer

 

65

   

Working Group 2  Controlling Animal Influenza and Decreasing Animal-to-Human Transmission

 

69

   

 Report to Plenary Rapporteur: Dr. Bruce Innis

 

69

Suggested Citation:"Front Matter." Institute of Medicine. 2005. John R. La Montagne Memorial Symposium on Pandemic Influenza Research: Meeting Proceedings. Washington, DC: The National Academies Press. doi: 10.17226/11448.
×
   

 Working Group 2 Briefing Slides: Controlling animal Influenza and Decreasing Animal-to-Human Transmission-Dr. Swayne, Briefer

 

73

   

Working Group 3  Influenza Diagnostics for Surveillance

 

80

   

 Report to Plenary Rapporteur-Dr. Alan Hay

 

80

   

 Working Group 3 Briefing Slides: Challenges and Strategies for Detection and Characterization of Influenza Viruses: Surveillance and Diagnosis-Dr. Cox, Briefer

 

83

   

Working Group 4  Antivirals and Non-Specific Approaches, Treatments and Immunotherapies

 

88

   

 Report to Plenary Rapporteur: Dr. Charles Hackett

 

88

   

 Working Group 4 Presentation Slides: Antivirals and Non-Specific Approaches, Treatments and Immunotherapies-Dr. Hackett, Rapporteur

 

91

   

 Working Group 4 Briefing Slides: Antivirals and Non-Specific Approaches, Treatments and Immunotherapies-Dr. Hayden, Briefer

 

93

5

 

AFTERNOON DISCUSSION: REACTION TO RAPPORTEURS, DAY 1

 

99

6

 

PLENARY SPEAKERS, DAY 2

 

103

   

 Modeling and Pandemic Preparedness,

 

103

   

 Professor Neil Ferguson, Professor of Mathematical Biology, Faculty of Medicine, Imperial College of London

 

103

   

 Clinical Trials of Potential Pandemic Vaccines: Key Issues

 

110

   

 Dr. John Treanor, Associate Professor of Medicine and Microbiology and Immunology, University of Rochester Medical Center

 

110

   

 Plenary Presentation Slides-Dr. John Treanor

 

117

   

 Research Issues in Animal Surveillance

 

124

   

 Dr. Robert Webster, Professor and Chair, Department of Infectious Diseases, St. Jude’s Children’s Research Hospital

 

124

   

 Plenary Presentation Slides-Dr. Webster

 

128

7

 

MORNING PLENARY DISCUSSION, DAY 2 (APRIL 5, 2005)

 

133

   

 Moderator: Dr. Harvey Fineberg

 

133

8

 

WORKING GROUPS, DAY 2

 

137

   

WORKING GROUP 5:  Immunology, Assay Standardization, and Correlates of Protection

 

137

   

 Rapporteur Report—Dr. Ann Arvin

 

137

   

 Working Group 5 Presentation Slides: Immunology, Assay Standardization, and Correlates of Protection-Ann Arvin, Rapporteur

 

140

   

 Working Group 5 Briefing Slides: Immunology, Assay Standardization, and Correlates of Protection-Dr. Brian Murphy, Briefer

 

141

   

WORKING GROUP 6:  Pandemic Vaccines—Assessment, Development and Production Strategies

 

142

   

 Rapporteur Report-Dr. Regina Rabinovich

 

142

   

 Working Group 6 Presentation: Pandemic Vaccines-Assessment, Development and Production Strategies, Dr. Rabinovitch, Rapporteur

 

145

   

 TABLE 1 Research Priorities for Vaccine Assessment, Development, and Production

 

146

Suggested Citation:"Front Matter." Institute of Medicine. 2005. John R. La Montagne Memorial Symposium on Pandemic Influenza Research: Meeting Proceedings. Washington, DC: The National Academies Press. doi: 10.17226/11448.
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The Institute of Medicine (IOM) of the National Academies of Science held a symposium, in memory of Dr. John R. La Montagne on April 4-5, 2005, to discuss the current state of the art of research on pandemic influenza and to identify gaps in research. The symposium serves as a first step of discussion towards a combined and coordinated research effort among Department of Health and Human Services agencies, other governmental agencies, international partners and the private sector. The statement of task that guided the Symposium agenda included these specific questions:

  1. What is the current state of the science on pandemic influenza research?
  2. What are the pressing unmet scientific questions and technical issues?
  3. What administrative, logistic or legal impediments exist that block progress towards the development of interventions to respond to pandemic influenza?
  4. How can collaboration among Global health Security Action Group nations be strengthened to address unmet scientific questions and technical issues related to research on pandemic influenza?
  5. What do experts believe are the most important next steps to take to advance research on pandemic influenza?

The Proceedings of the John La Montagne Memorial Symposium on Pandemic Influenza Research Gaps represents a slightly edited transcript of the plenary presentations, rapporteur presentations, plenary discussion and presentation slides. This document contains the Symposium agenda, short biographies of plenary speakers, and provides a list of individuals who attended the symposium.

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