FIGURE D-2 Comparison of bone concentrations in humans and rats on the basis of estimated dose.

To keep the results visible, the figure omits the high data point from Maurer et al. (11.3 mg of fluoride/kg/day, 16,760 mg/kg ash).

Male rats: NTP (humerus), Dunipace (femur), Maurer (radius and ulna).

Zipkin data: Regression results from crude and adjusted model, the latter assuming males and 70 years residency.

Regression results:



y = 415 + 2,664x (r2 = 0.98)


y = 145 + 1,283x (r2 = 0.99)


y = 1,911+1,345x (r2 = 0.98)

Human (crude):

y = 517 + 1,549(70/2)x

Human (adjusted to male, 70 years residence):

y = 1,300 + 1,527(70/2)x

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