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National Institutes of Health Sleep-Related Initiatives: 1994–2004



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F National Institutes of Health Sleep-Related Initiatives: 1994–2004 351

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TABLE F-1 Sleep Initiatives (RFAs) Sponsored by the National Institutes of Health, 1994–2004 Participating Funding 352 Title Primary Purpose Institutes/Centers Activity Year NHLBI P50 1996 SCOR in Neurobiology of Establish specialized centers of research (SCORs) pro- Sleep & Sleep Apnea: grams to foster translational research. RFA-HL-96-014 NHLBI, NIMH, R01 1996 Molecular Biology and Advance the understanding of the molecular and genetic NICHD Genetics of Sleep and Sleep basis of sleep and sleep disorders. Disorders: RFA-HL-96-015 NHLBI K07 1996, 1997 Sleep Academic Award: Develop and/or improve the quality of medical curricula HL-97-015; HL-96-021 for the prevention, management, and control of sleep disorders. NHLBI, NIDR, R01 1997 Obstructive Sleep Apnea in Define abnormalities in airway structure and function NICHD Children: responsible for obstructive sleep apnea in children, and HL-98-004 identify physiological and clinical measures associated with increased morbidity. NHLBI, NIMH, R01 1998 Phenotypic Characterization Develop improved molecular, cellular, and systems NIA, NINDS of Sleep in Mice: approaches to investigate sleep and circadian phenotypes RFA-HL-99-001 in mice. Nocturnal Asthma, Chrono- Establish the mechanisms that underlie the chronobiology NHLBI R01 1999 biology, and Sleep: of nocturnal exacerbations of asthma and airway inflam- RFA-HL-99-011 mation, as well as the role played by sleep and sleep disturbances. Implementation of the Develop knowledge that can be used in preventing NIOSH, NCI, R01, R18 1999 NHLBI, NIA, National Occupational occupational diseases and injuries and to better under- NIDCD, NIEHS Research Agenda: stand their underlying pathophysiology. RFA-OH-99-002 Data Coordinating Center Establish a new data coordinating center for the Sleep NHLBI U01 1999 for Sleep Heart Health Heart Health Study. Study: RFA-HL-99-014 NIAAA R01, R21 2000 Research on Alcohol and Stimulate research on alcohol and sleep in areas that may Sleep: improve understanding of the etiology and treatment of RFA-AA-00-005 alcoholism.

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NHLBI R01 2000 Oxygen Sensing During Improve understanding of how intermittent hypoxia Intermittent Hypoxia: contributes to the pathophysiology of cardiopulmonary, RFA-HL-00-004 vascular, hematological, and sleep disorders. NIDDK, R01 2000 Ancillary Studies in Con- Develop basic, clinical, and behavioral ancillary research NHLBI, NINR, junction with SHOW Trial: studies of the Study of Health Outcomes of Weight-Loss NIAMS, NIDCR RFA-DK-00-017 (SHOW) clinical trial. NHLBI, NIDA R01 2001 Interrelationships Between Elucidate characteristics of sleep physiology, sleep Sleep and Heart, Lung, and disorders, and pathophysiological mechanisms mediating Blood Diseases: the interrelationship between sleep disturbance and heart, RFA-HL-01-009 lung, and blood diseases. NHLBI, NIMH, R01 2001 Sleep and Sleep Disorders in Improve the understanding of fundamental biological NINR, NICHD Children: mechanisms through which sleep deprivation and sleep RFA-HL-01-006 disorders affect the cardiopulmonary, hematological, immunological, mental, and behavioral health of children. Role of Sleep and Sleep Elucidate the relationship of sleep deprivation and sleep- NHLBI, NIA R01 2002 Disordered Breathing in the disordered breathing to characteristics of the metabolic Metabolic Syndrome: syndrome including obesity, high blood pressure, dyslipi- RFA-HL-03-008 demia, insulin resistance, and vascular inflammation. NHLBI, NIMH R01 2003 Inter-relationships of Sleep, Elucidate the etiology of sleep disturbances and fatigue Fatigue, and HIV/AIDS: associated with human immunodeficiency virus infection RFA-HL-04-010 and acquired immunodeficiency disease syndrome. NOTE: Primary purpose of each PA and RFA are adapted from language in NIH announcements. NCCAM = National Center for Complementary and Alternative Medicine; NCI = National Cancer Institute; NCSDR = National Center on Sleep Disorders Research; NHLBI = National Heart, Lung, and Blood Institute; NIA = National Institute on Aging; NIAAA = National Institute on Alcohol Abuse and Alcoholism; NIAID = National Institute of Allergy and Infectious Diseases; NIAMS = National Institute of Arthritis and Musculoskeletal and Skin Diseases; NICHD = National Institute of Child Health and Human Development; NIDA = National Institute on Drug Abuse; NIDCD = National Institute on Deafness and Other Communi- cation Disorders; NIDCR = National Institute of Dental and Craniofacial Research; NIDDK = National Institute of Diabetes and Digestive and Kidney Diseases; NIDR = National Institute of Dental Research; NIEHS = National Institute of Environmental Health Sciences; ; NIH= National Institutes of Health; NIMH = National Institute of Mental Health; NINDS = National Institute of Neurological Disorders and Stroke; NINR = National Institute of Nursing Research; NIOSH = National Institute for Occupational Safety and Health; PA = program announcement; RFA = request for application. SOURCE: National Heart, Lung, and Blood Institute, 2003; National Sleep Disorders Research Plan, 2003. Bethesda, MD: NIH. 353

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354 TABLE F-2 Sleep Initiatives (PAs) Sponsored by the National Institutes of Health, 1994–2004 Participating Funding Title Primary Purpose Institutes/Centers Activity Year Enhance sleep research in the following areas: neuroscience R01, R03, 1994 Basic and Clinical Research NIA, NIAAA, NICHD, on Sleep & Wakefulness: NIDA, NHLBI, NIMH, and behavioral science; molecular and cellular mechanisms of R29, P01 sleep and circadian rhythms across the life span; development PA-95-014 NINDS, NINR of sleep from fetal life through infancy; role of dreaming in humans; etiological factors and pathophysiology of transient or persistent insomnia; and the treatment of sleep disorders. Support research to identify, create, and develop innovative R21 1996 Innovative Approaches NCRR technologies and to provide these technologies for biomedical to Developing New Technologies: PA-97-014 research. Research on Musculoskeletal NIAMS, NICHD, Study a broad range of basic and clinical topics related to R01, R03, 1997 musculoskeletal fitness, exercise physiology, and sports R29, K01, Fitness and Sports Medicine: NINR medicine. K02, K08, PA-97-025 P01 Institutional National NHLBI, NIA, NIAAA, Ensure that scientists, highly trained in sleep research, are T32 1997 available in adequate numbers to address important gaps in Research Service Award in NICHD, NIDA, our biomedical and biological understanding of sleep, Sleep Research: NIMH, NINDS, NINR PA-97-064 including those outlined in the NIH director’s Sleep Disorders Research Plan. Support basic bioengineering research whose outcomes are R01 1998 Bioengineering Research NCI, NCRR, NEI, likely to advance health or health-related research within the Grants: NHGRI, NHLBI, NIA, PAR-99-009 NIAAA, NIAID, mission of the NIH. NIAMS, NICHD, NIDA, NIDCD, NIMH, NINDS, NINR, NLM

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NIMH, NIDA, NSF, Encourage and support investigator-initiated, neuroinfor- R01, P01, 1999 Human Brain Project matics research that will lead to new digital and electronic P20 (Neuroinformatics): NIA, NICHD, NIDCD, PAR-99-138 NLM, NASA, FIC, tools for all domains of neuroscience research. DOE, NIAAA, NHLBI, NIDCR, NCI, NINDS Develop knowledge that can be used in preventing occupa- R01 1999 Occupational Safety and NIOSH, NCI, NHLBI, Health Research: NIA, NIAAA, NIAID, tional diseases and injuries, and better understand their NIAMS, NIDCD, NIEHS underlying pathophysiology. PA-99-143 NINDS, NHLBI, NIA, Develop an understanding of the pathogenesis of RLS and R01 2001 Restless Legs Syndrome and PLMD that will lead to new forms of treatment. Periodic Limb Movement NIMH Disorder: PA-01-086 Research on Sleep and Sleep NHLBI, NCSDR, NIA, Advance biomedical knowledge related to sleep or sleep R01, R21 2004 NIAAA, NIAMS, NCI, disorders; improve understanding of the neurobiology or Disorders: functions of sleep over the life span; enhance timely diagnosis PA-05-046 NICHD, NCCAM, NIDA, NIMH, NINDS, and effective treatment for individuals affected by sleep- NINR, ORWH related disorders; or implement and evaluate innovative community-based public health education and intervention programs. NOTE: Primary purpose of each PA and RFA are adapted from language in NIH announcements. DOE = Department of Energy; FIC = Fogarty International Center; NASA = National Aeronautics and Space Administration; NCCAM = National Center for Complementary and Alternative Medicine; NCI = National Cancer Institute; NCRR = National Center for Research Resources; NCSDR = National Center on Sleep Disorders Research; NEI = National Eye Institute; NHGRI = National Human Genome Research Institute; NHLBI = National Heart, Lung, and Blood Institute; NIA = National Institute on Aging; NIAAA = National Institute on Alcohol Abuse and Alcoholism; NIAID = National Institute of Allergy and Infectious Diseases; NIAMS = National Institute of Arthritis and Musculoskeletal and Skin Diseases; NICHD = National Institute of Child Health and Human Development; NIDA = National Institute on Drug Abuse; NIDCD = National Institute on Deafness and Other Communication Disorders; NIDCR = National Institute of Dental and Craniofacial Research; NIEHS = National Institute for Environmental Health Sciences; NIH= National Institutes of Health; NIMH = National Institute of Mental Health; NINDS = National Institute of Neurological Disorders and Stroke; NINR = National Institute of Nursing Research; NIOSH = National Institute for Occupational Safety and Health; NLM = National Library of Medicine; NSF = National Sleep Foundation; ORWH = Office of Research on Women’s Health; PA = program announcement; RFA = request for application. 355 SOURCES: National Heart Lung and Blood Institute, 2003; National Sleep Disorders Research Plan, 2003. Bethesda, MD: NIH.