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Preterm Birth: Causes, Consequences, and Prevention (2007)
Board on Health Sciences Policy (HSP)

Page
625
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Preterm Birth: Causes, Consequences, and Prevention

TABLE B-5 Immutable Medical Risk Factors Associated with Preterm Birth

Previous low birth weight or preterm delivery

Multiple 2nd trimester spontaneous abortion

Prior first trimester induced abortion

Familial and intergenerational factors

History of infertility

Nulliparity

Placental abnormalities

Cervical and uterine anomalies

Gestational bleeding

Intrauterine growth restriction

In utero diethylstilbestrol exposure

Multiple gestations

Infant sex

Short stature

Low prepregnancy weight/low body mass index

Urogenital infections

Preeclampsia

research on the efficacy of antibiotic therapy for the prevention of preterm delivery from these infections continues.

Demographic risks associated with preterm delivery include African American race, single marital status, low socioeconomic status, maternal age, and others (Table B-6). Although demographic factors cannot cause the premature expulsion of a fetus, these factors may antagonize some other risk factor(s).

Social, behavioral, stress, and maternal psychological factors have frequently been linked to pregnancy outcomes; and chronic stress has been related to low socioeconomic status (5766). There have been difficulties in measuring the amount of stress caused by life events, but consistent associations between perceived stress and preterm birth have been reported.

TABLE B-6 Demographic Risk Factors Associated with Preterm Birth

Race/ethnicity

Single Marital Status

Low Socioeconomic status

Seasonality of pregnancy and birth

Maternal Age

Employment-related physical activity

Occupational exposures

Environment exposures

Page
625
Front Matter (R1-R18)
Summary (1-30)
1 Introduction (31-52)
SECTION I Measurement : 2 Measurement of Fetal and Infant Maturity (53-83)
Section I Recommendations (84-86)
SECTION II Causes of Preterm Birth: 3 Behavioral and Psychosocial Contributors to Preterm Birth (87-123)
4 Sociodemographic and Community Factors Contributing to Preterm Birth (124-147)
5 Medical and Pregnancy Conditions Associated with Preterm Birth (148-168)
6 Biological Pathways Leading to Preterm Birth (169-206)
7 Role of Gene-Environment Interactions in Preterm Birth (207-228)
8 Role of Environmental Toxicants in Preterm Birth (229-254)
Section II Recommendations (255-258)
SECTION III Diagnosis and Treatment of Preterm Labor: 9 Diagnosis and Treatment of Conditions Leading to Spontaneous Preterm Birth (259-307)
Section III Recommendations (308-310)
SECTION IV Consequences of Preterm Birth: 10 Mortality and Acute Complications in Preterm Infants (311-345)
11 Neurodevelopmental, Health, and Family Outcomes for Infants Born Preterm (346-397)
12 Societal Costs of Preterm Birth (398-429)
Section IV Recommendations (430-432)
SECTION V Research and Policy: 13 Barriers to Clinical Research on Preterm Birth and Outcomes of Preterm Infants (433-454)
14 Public Policies Affected by Preterm Birth (455-472)
Section V Recommendations (473-476)
15 A Research Agenda to Investigate Preterm Birth (477-492)
References (493-590)
Appendix A Data Sources and Methods (591-603)
Appendix B Prematurity at Birth: Determinents, Consequences, and Geographic Variation (604-643)
Appendix C A Review of Ethical Issues involved in Premature Birth (644-687)
Appendix D A Systematic Review of Costs Associated with Preterm Birth (688-724)
Appendix E Selected Programs Funding Preterm Birth Research (725-731)
Appendix F Committee and Staff Biographies (732-740)
Index (741-772)