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Visualizing Chemistry: The Progress and Promise of Advanced Chemical Imaging B Committee Member Biographies CHAIR NANCY B. JACKSON is deputy director of the International Security Center at Sandia National Laboratories, where she is responsible for overseeing the international security programs, initiatives, and operations and coordinates the labwide initiative on Global Nuclear Futures, bringing together the nuclear energy and nonproliferation centers of the laboratory. Her technical experience lies primarily in the areas of spectroscopy and surface reactivity. Spectroscopic applications include fluorescence imaging of DNA microarrays, infrared imaging for analysis of polymeric materials, and point infrared spectroscopy for the study of structure-property relationships for heterogeneous catalytic materials. In addition, Dr. Jackson has managed research in the analysis of hyperspectral images for remote sensing and the hyperspectral analysis of materials using various chemical imaging instrumentation. Dr. Jackson earned her bachelor’s degree in chemistry from George Washington University and her Ph.D. in chemical engineering from the University of Texas, Austin. Dr. Jackson is a member of the Board of Directors of the American Chemical Society and a fellow of the American Association for the Advancement of Science. MEMBERS PIERRE CHAURAND is currently research associate professor of biochemistry at Vanderbilt University (Nashville, TN). Among Dr. Chaurand’s interests is research that combines cutting edge mass spectrometry technology and other tech-
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Visualizing Chemistry: The Progress and Promise of Advanced Chemical Imaging nologies for profiling, identifying, and mapping the spatial distribution of bio-compounds directly in biological samples and the translation of these exciting new molecular technologies to the investigation of diseased tissues. In 1997, Dr. Chaurand received the annual young investigator prize from the French Mass Spectrometry Society. Dr. Chaurand obtained his Ph.D. in physical biochemistry and mass spectrometry in 1994 from the University of Paris Sud (Orsay, France). JULIA E. FULGHUM currently serves as the chair of the University of New Mexico Chemical and Nuclear Engineering Department. Her research interests include materials characterization with an emphasis on multitechnique correlation and multivariate analysis for nondestructive evaluation of heterogeneous samples: X-ray photoelectron spectroscopy, time-of-flight secondary ion mass spectrometry, atomic force microscopy, Fourier-transform infrared spectroscopy. Prior to her current appointment, Dr. Fulghum was a faculty member in the Department of Chemistry at Kent State University (KSU) from August 1989 to August 2002, serving as an Honors College faculty member during her last two years. At KSU, she received the distinguished teacher award from the College of Arts and Sciences and was named outstanding faculty mentor in the Teaching Scholars Program, both in 2001. Dr. Fulghum serves as chair of the Advisory Board of the National ESCA (Electron Spectroscopy Chemical Analysis) and Surface Analysis Center for Biomedical Problems (NESAC/BIO) and is a member of the editorial advisory board for Surface and Interface Analysis and for the Journal of Electron Spectroscopy and Related Phenomena. In addition, she is active in the Applied Surface Science Division of the American Vacuum Society, where she has served as chair, program chair, and member-at-large. Dr. Fulghum received her Ph.D. in analytical chemistry in 1987 from the University of North Carolina, her master’s degree in analytical chemistry in 1983 from Cornell University, and her bachelor’s degree in chemistry with highest honors in 1981 from the University of North Carolina. RIGOBERTO HERNANDEZ is associate professor of chemistry at Georgia Institute of Technology. His research interests focus on microscopic reaction dynamics and their effects on macroscopic chemical reaction rates in arbitrary solvent environments. His projects include the use of modeling to determine the chemical reaction dynamics of thermosetting polymers and living polymers, the diffusion of mesogens in a liquid crystal, the transport and control of adsorbates on a surface, the binding dynamics of proteins, and the dynamics of protein folding and rearrangement. Dr. Hernandez’ awards include the Goizueta Foundation Junior Professorship (2002-2006); Sigma Xi Southeast Regional Young Investigator (2002); Alfred P. Sloan Fellow and Sigma Xi Southeast Regional Young Investigator (2000); Research Corporation Cottrell Scholar and Sigma Xi Young Faculty Award (1999); Blanchard Assistant Professorship of Chemistry (1999-2001); and National Science Foundation (NSF) CAREER Award (1997).
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Visualizing Chemistry: The Progress and Promise of Advanced Chemical Imaging He was elected fellow of the American Academy of Arts and Science, in 2004. Dr. Hernandez received his B.S.E. from Princeton University in 1989 and Ph.D. from the University of California at Berkeley (1993). He was a Feinberg postdoctoral fellow at the Weizmann Institute of Science (1994) and a postdoctoral fellow at the University of Pennsylvania (1996). DANIEL A. HIGGINS has served on the chemistry faculty at Kansas State University since 1996, where he currently holds the rank of associate professor. He conducts research involving the implementation of novel optical microscopic techniques for the characterization of mesostructured thin-film materials. He utilizes techniques such as near-field scanning optical microscopy (NSOM), single-molecule spectroscopy (SMS), and multiphoton-excited fluorescence microscopy to study organic polymer films, polymer-liquid crystal composites, polymer-surfactant complexes, and sol-gel derived silicate glass films. Dr. Higgins is a National Science Foundation (NSF) CAREER Award recipient and has received a 3M Company Untenured Faculty Research Award. Dr. Higgins received a B.A. from St. Olaf College (1988) and a Ph.D. from the University of Wisconsin, Madison (1993). He performed postdoctoral research at the University of Minnesota, where he held an NSF postdoctoral fellowship in chemistry. ROBERT HWANG is the former director of the Center for Functional Nano-materials at Brookhaven National Laboratory (BNL). He has recently returned to Sandia National Laboratories. Prior to his arrival at BNL, he managed the Thin Film and Interface Science Department at Sandia National Laboratories. He is currently a member of the Board on Chemical Sciences and Technology. Dr. Hwang received his B.S. from the University of California at Los Angeles and his Ph.D. from the University of Maryland. KATRIN KNEIPP is currently an associate professor at Harvard Medical School, Wellman Center for Photomedicine, where she works on new spectroscopic methodologies for applications in life sciences and nanotechnology. Her current research focuses on combining modern laser spectroscopy with the exciting optical properties of nanostructures. By exploiting local optical fields of nanoparticles, molecular characterization and chemical imaging can be performed at the single-molecule level and from probed volumes on the nanoscale. Dr. Kneipp’s research interests also include detection and structural characterization of single bio-medically relevant molecules, as well as molecular probing in single living cells. Dr. Kneipp’s work has been profiled in the New Scientist and the American Institute of Physics Bulletin. She received the Rockefeller-Mauze visiting chair award at Massachusetts Institute of Technology from 2000 to 2001 and the 1999 Meggers Award of the Society for Applied Spectroscopy. Dr. Kneipp received both her Ph.D. in physics and her Dr.Sc. in physical chemistry from the Friedrich-Schiller-University, Jena (Germany).
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Visualizing Chemistry: The Progress and Promise of Advanced Chemical Imaging ALAN P. KORETSKY is chief of the Laboratory of Functional and Molecular Imaging and director of the National Institutes of Health (NIH) Magnetic Resonance Imaging (MRI) Research Facility at the National Institute of Neurological Disorders and Stroke (NINDS). Dr. Koretsky’s laboratory is interested in two main areas: actively developing novel imaging techniques to visualize brain function and studying the regulation of cellular energy metabolism combining molecular genetics with noninvasive imaging tools. Dr. Koretsky spent 12 years on the faculty in the Department of Biological Sciences at Carnegie Mellon University, where he was the Eberly Professor of Structural Biology and Chemistry before coming to NINDS in 1999. Dr. Koretsky received his S.B. degree from the Massachusetts Institute of Technology and Ph.D. from the University of California at Berkeley. He performed postdoctoral work in the National Heart, Lung, and Blood Institute at NIH, studying regulation of mitochondrial metabolism using optical and nuclear magnetic resonance techniques. Dr. Koretsky was the recipient of the Gold Medal, the highest honor of the International Society of Magnetic Resonance, for his work in developing MRI tools to measure regional blood flow and image transgenic mice, and in the development of manganese-enhanced MRI. CAROLYN LARABELL is professor of anatomy at the University of California, San Francisco, and concurrently holds a position in the Physical Biosciences Division at Lawrence Berkeley Laboratories. She conducts research using both electron and confocal microscopy and is currently developing the technology to obtain three-dimensional tomographic reconstructions of whole, hydrated cells at better than 50 nm isotropic resolution and to localize proteins and protein complexes in those cells using soft X-ray microscopy . Along with Dr. Mark Le Gros, she was awarded a $5.5 million grant from the Department of Energy and the National Institutes of Health to build a state-of-the-art X-ray microscope at Lawrence Berkeley National Laboratory to advance cellular and molecular biology and biomedical studies. Dr. Larabell received her Ph.D. in zoology from Arizona State University. STEPHAN STRANICK is currently a senior scientist in the Chemical Science and Technology Laboratory of the National Institute of Standards and Technology. His present research focuses on the development of novel proximal probes of surface physiochemical properties, especially in chemical imaging, using near-field optical microscopy. He has published more than 50 papers on the subject and has been awarded 14 patents associated with scanned probe microscopies for chemical and electrical characterization. Dr. Stranick’s awards include the American Chemical Society’s Nobel Laureate Signature Award, the American Chemical Society’s Procter & Gamble Award in Physical Chemistry, the American Chemical Society’s Arthur F. Findeis Award for Achievement by a Young Analytical Scientist, a BF Goodrich Inventors Award, the Union Carbide Kenan Analytical Award, the Xerox President’s Award in Materials Research, the
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Visualizing Chemistry: The Progress and Promise of Advanced Chemical Imaging Samuel Wesley Stratton Award for Excellence in Science and Engineering, and the Department of Commerce Bronze Metal Award for Superior Federal Service. Dr. Stranick received his B.S. in chemistry from Ithaca College (1989) and his Ph.D. in chemistry from Pennsylvania State University (1995). WATT WEBB joined the Cornell faculty in 1961, served as director of the School of Applied and Engineering Physics from 1983 to 1989, and is currently a member of the graduate faculties of seven fields. In addition to directing the Developmental Resource for Biophysical Imaging Opto-electronics, he serves on the board of directors and executive committee of the Cornell Research Foundation. Dr. Webb is also affiliated with the university’s Biophysics Program, the Cornell Center for Materials Research, and the National Biotechnology Center and serves on the Life Sciences Advisory Council. He is a fellow of the American Physical Society (APS) and the American Association for the Advancement of Science; a founding fellow of the American Institute of Medical and Biological Engineers; and an elected member of the National Academy of Engineering, National Academy of Sciences, and American Academy of Arts and Sciences. He won the APS Biological Physics Prize in 1990, the Ernst Abby Lecture Award in 1997, the Michelson-Morley Award in 1999, and the Rank Prize for Opto-electronics in 2000; he was the Jablonski Award lecturer in 2001 and the 2002 national lecturer of the Biophysical Society, and he has served as chairman of the Division of Biological Physics and associate editor of Physical Review Letters. Currently, his studies involve new experimental technologies to study the dynamics of bio-molecular life processes, including multiphoton microscopy, fluorescence correlation spectroscopy, and nanoscopic molecular tracking. Dr. Webb received both his B.S. (1947) and his Sc.D. (1955) from the Massachusetts Institutes of Technology. PAUL WEISS currently serves as distinguished professor of chemistry and physics at the Pennsylvania State University, where he began his academic career in 1989. His research efforts are focused on gaining atomic-scale understanding and control of materials properties, and his group performs exploration, probing, and manipulation of the interactions and dynamics at surfaces and interfaces using scanning tunneling microscopy and related techniques. He advances scanning probe microscopy and nanolithography through developing new methods and capabilities in each. He and his group also develop and explore physical models of biological systems. Dr. Weiss received both his bachelor’s and master’s degrees in chemistry from the Massachusetts Institute of Technology (1980) and his Ph.D. in chemistry from the University of California at Berkeley (1986). He was a postdoctoral member of the technical staff at AT&T Bell Laboratories (1986-1988) and a visiting scientist at IBM (Almaden Research Center, 1988-1989). Dr. Weiss’ awards and honors include the Scanning Microscopy International Presidential Scholarship (1994), the B.F. Goodrich Collegiate Inventors Award (1994), the
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Visualizing Chemistry: The Progress and Promise of Advanced Chemical Imaging American Chemical Society Nobel Laureate Signature Award for Graduate Education in Chemistry (1996), and the National Science Foundation Creativity Award (1997-1999); he was elected a fellow of the American Association for the Advancement of Science (2000) and the American Physical Society (2002). NEAL WOODBURY joined the faculty of Arizona State University in 1987, where he is currently professor of chemistry and biochemistry. In addition, he serves as director of the university’s Center for BioOptical Nanotechnology in the Biodesign Institute and served as the director of the Photosynthesis Center from 1997 until 2000. Dr. Woodbury was a pioneer in using photophysical principles to study the mechanism and dynamics of biochemical reactions such as photosynthetic energy conversion. By using laser technology and focusing on reactions initiated by light, Dr. Woodbury and his team made significant progress in understanding ways in which energy can be harnessed from light to both probe and manipulate biological reactions. An advocate of interdisciplinary science, he believes that a broad-based understanding of biology, chemistry, and physics provides researchers greater vision in addressing real-world problems. To this end, he directs a National Science Foundation Integrative Graduate Education and Research Traineeship (IGERT) program, bringing together students from physical sciences, life sciences, and engineering. He is an active member of the American Chemical Society, Biophysical Society, and American Photobiology Society and is coauthor of more than 75 published articles and studies. Dr. Woodbury received his B.S in biochemistry from the University of California, Davis (1979), and his Ph.D. in biochemistry from the University of Washington (1986). XIAOLIANG SUNNEY XIE is professor of chemistry and chemical biology at Harvard University, where his research is focused on imaging, spectroscopy, and the dynamics of single biomolecules and single cells. He and his research group did pioneering work on fluorescence studies of single molecules at room temperature, near-field microscopy, single-molecule enzymology, and coherent anti-Stokes Raman scattering microscopy. Prior to joining the faculty of Harvard, Dr. Xie was a chief scientist in the Environmental Molecular Sciences Laboratory at Pacific Northwest National Laboratory. Dr. Xie received his B.S. in chemistry from Peking University (1984) and his Ph.D. in chemistry from the University of California at San Diego (1990); he did his postdoctoral work at the University of Chicago (1990-1991). He currently serves on the advisory boards of several government and academic institutions, as well as several journals including Annual Review of Physical Chemistry, Accounts of Chemical Research, and Journal of Physical Chemistry. He has coauthored more than 100 papers and holds three patents. Past awards include the National Institute of Health’s Director’s Pioneer Award (2004), the Raymond and Beverly Sackler Prize in the Physical Sciences (2003), and the Coblentz Award from the Coblentz Society (1996).
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Visualizing Chemistry: The Progress and Promise of Advanced Chemical Imaging EDWARD YEUNG is on the chemistry faculty at Iowa State University, where he is currently distinguished professor in liberal arts and sciences. His research interests span both spectroscopy and chromatography, with publications in areas such as nonlinear spectroscopy, laser-based detectors for liquid chromatography, capillary electrophoresis, trace-gas monitoring, single-cell and single-molecule analysis, DNA sequencing, and data treatment procedures in chemical measurements. He is an associate editor of Analytical Chemistry and has served on the editorial advisory board of Progress in Analytical Spectroscopy, Journal of Capillary Electrophoresis, Microchimica Acta, Spectrochimica Acta Part A, Journal of Microcolumn Separations, Electrophoresis, Journal of High Resolution Chromatography, Chromatographia, and Journal of Biochemical and Biophysical Methods. Past awards include the Alfred P. Sloan Fellowship in 1974, the American Chemical Society Awards in Analytical Chemistry (1994) and Chromatography (2002), the International Prize of the Belgian Society of Pharmaceutical Sciences (2002), and election as a fellow of the American Association for the Advancement of Science in 1992. Dr. Yeung received his A.B. degree in chemistry from Cornell University in 1968 and his Ph.D. in chemistry from the University of California at Berkeley in 1972.