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OCR for page 261
Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship - Workshop Summary
APPENDIX A
Forum on Microbial Threats
Board on Global Health
Institute of Medicine
The National Academies
Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship
March 16–March 17, 2005
KECK 100
National Academies
500 Fifth Street, N.W.
Washington, D.C. 20001
AGENDA
WEDNESDAY, MARCH 16, 2005
8:30–9:00
Continental Breakfast
9:00
Welcome and Opening Remarks
Stanley Lemon, The University of Texas Medical Branch, Galveston; Chair, Forum on Microbial Threats
OCR for page 262
Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship - Workshop Summary
9:15
Arms Races with Evolving Diseases: “We’ve Met the Enemy and He Is Us”
Joshua Lederberg, Rockefeller University
Stanley Falkow, Stanford University
10:15
Discussion
10:30
Break
Session I: Host-Pathogen Interactions: Defining the Concepts of Pathogenicity, Virulence, Colonization, Commensalism, and Symbiosis
Moderator:
P. Frederick Sparling, University of North Carolina Vice-chair, Forum on Microbial Threats
10:45
Colonization
Jeffrey I. Gordon, Washington University School of Medicine, or, Karen Guillemin, University of Washington
11:45
Discussion
12:15
Lunch—Welcoming Remarks by Dr. Harvey Fineberg, President, Institute of Medicine
1:00–2:30
Commensalism and Symbiosis—Host, Microbial, and Environmental Factors
Abigail Salyers, University of Illinois, Champaign-Urbana
Jo Handelsman, Department of Plant Pathology, University of Wisconsin, Madison
2:30–2:45
Discussion
2:45–3:00
Break
3:00–4:15
Pathogenicity and Virulence
Martin Blaser, New York University School of Medicine
BJ Staskawicz, University of California, Berkeley
4:15–5:45
Open Discussion of Day 1
Moderator:
David Relman, Stanford University
Balfor Sartor, University of North Carolina
Maria G. Dominguez-Bello, University of Puerto Rico, Rio Piedras
5:45
Adjournment of the first day
OCR for page 263
Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship - Workshop Summary
6:00
Reception
7:15
Dinner Meeting of the Forum on Microbial Threats [location TBD]
THURSDAY, MARCH 17, 2005
8:00–8:30
Continental Breakfast
8:30
Opening Remarks/Summary of Day 1
P. Frederick Sparling, University of North Carolina Vice-chair, Forum on Microbial Threats
Session II: Ecology of Host-Microbe Interactions
Moderator: Stephen S. Morse, Columbia University
8:40–9:25
Endogenous Microbial Communities
David Stahl, University of Washington
Mark E.J. Woolhouse, Centre for Tropical Veterinary Medicine, University of Edinburgh
9:25–10:15
How the Host “Sees” and Responds to Pathogens
Marian Neutra, Harvard Medical School and Children’s Hospital
David Relman, Stanford University
10:15–10:30
Discussion
10:30–10:45
Break
Session III: Understanding the Dynamic Relationships of Host-Microbe Interactions—Discussion Panel
Moderator:
David Relman, Stanford University
10:45–12:15
Lonnie King, Michigan State University
Stanley Falkow, Stanford University
Jeffrey I. Gordon, Washington University School of Medicine
12:15–12:45
Lunch
OCR for page 264
Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship - Workshop Summary
Session IV: Novel Approaches for Mitigating the Development of Resistance
Moderator:
James Hughes, Emory University
12:45–1:30
Using Pre- and Probiotics to Modify Host-Environmental Factors to Promote Health and Mitigate Disease
Michiel Kleerebezem, Holland
Suzanne Cunningham-Rundles, Cornell University
1:30–2:00
Governmental Approaches to Regulating Pre- and Probiotics
Lorenzo Morelli, Istituto di Microbiologia UCSC—Italy
Julienne Vaillancourt, CBER, FDA
2:00–2:15
Discussion
Session V: Challenges and Opportunities to Developing a New Paradigm to Replace the “War Metaphor”
Moderator:
Fredrick Sparling, University of North Carolina, Chapel Hill
2:15–4:00 With the backdrop of the previous days’ presentations and discussion, Forum members, panel discussants, and the audience will comment on the issues and next steps that they would identify as priority areas for consideration within industry, academia, public health organizations, and other government sectors. The discussion of priorities will summarize the issues surrounding emerging opportunities for more effective collaboration as well as the remaining research and programmatic needs. The confounding issues of the major obstacles to preparing an optimal response, particularly as it relates to the complexities of interaction between private industry, research and public health agencies, regulatory agencies, policy makers, academic researchers, and the public, will be explored with an eye toward innovative responses to such challenges.
Panel Discussants:
Joshua Lederberg, Rockefeller University
David Stahl, University of Washington
4:00
Adjourn
Representative terms from entire chapter:
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