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Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues (2006)

Chapter: Appendix B Participants at Public Sessions

« Previous: Appendix A Biographic Information on the Committee on Human Health Risks of Trichloroethylene
Suggested Citation:"Appendix B Participants at Public Sessions." National Research Council. 2006. Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues. Washington, DC: The National Academies Press. doi: 10.17226/11707.
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APPENDIX B
Participants at Public Sessions

March 23, 2005, Washington, DC


Persons who made formal presentations


Richard Canady, Office of Science and Technology Policy

Weihsueh Chiu, U.S. Environmental Protection Agency

Peter Preuss, U.S. Environmental Protection Agency


Persons who represented sponsoring agencies


Peter Preuss, U.S. Environmental Protection Agency

Sandra Waisley, Department of Energy

Linda Wennerberg, Department of Defense

Richard Wickman, National Aeronautics and Space Administration


Persons who made comments at the open-microphone session


Jim Dix

Paul Dugard, Halogenated Solvents Industry Alliance, Inc.

Debra Hall, Hopewell Junction Citizens for Clean Water

Betty Havel, Village of Endicott Trustee

Sheila Holt-Orstead

Marge Horton

James Little, Resident Action Group of Endicott

Caffey Norman, Patton Boggs

Bernadette Patrick, Citizen Actions to Restore Endicott’s Environment

Suggested Citation:"Appendix B Participants at Public Sessions." National Research Council. 2006. Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues. Washington, DC: The National Academies Press. doi: 10.17226/11707.
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Jennifer Sass, Natural Resources Defense Council

Judy Schreiber, New York State Office of the Attorney General

Lenny Siegel, Center for Public Environmental Oversight

Bob Speigel, Edison Wetlands Association


April 20, 2005, Washington, DC


Persons who made comments at the open-microphone session


Paul Dugard, Halogenated Solvents Industry Alliance, Inc.

J. M. Ensminger

Jennifer Sass, Natural Resources Defense Council


June 9, 2005, Irvine, CA


Persons who made formal presentations


Weihsueh Chiu, U.S. Environmental Protection Agency

Shannon Cunniff, Department of Defense

Christopher DeRosa, Agency for Toxic Substances and Disease Registry

Mustafa Dosemeci, National Cancer Institute

Michael Dourson, Toxicology Excellence for Risk Assessment

Michael Kelsh, Exponent, Inc.

David Mattie, Air Force Research Laboratory

Patricia Stewart, National Cancer Institute


Persons who made comments at the open-microphone session


Cheryl Buchanan

Elizabeth Crawford

Amanda Evans

Neil Fishbein

Leonard Fisher

Jane Horton

Jonathan Parfrey

Lenny Siegel

Christina Walsh

Suggested Citation:"Appendix B Participants at Public Sessions." National Research Council. 2006. Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues. Washington, DC: The National Academies Press. doi: 10.17226/11707.
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Page 388
Suggested Citation:"Appendix B Participants at Public Sessions." National Research Council. 2006. Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues. Washington, DC: The National Academies Press. doi: 10.17226/11707.
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Page 389
Next: Appendix C Trichloroethylene Metabolism »
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Trichloroethylene is a chlorinated solvent widely used as a degreasing agent in industrial and manufacturing settings. It is also used as a chemical intermediate in making other chemicals and is a component of products such as typewriter correction fluid, paint removers, adhesives, and spot removers. In 2001, EPA issued a draft health risk assessment and proposed exposure standards for trichloroethylene. PA's Scientific Advisory Board (SAB) reviewed the draft and it was issued for public comment. A number of scientific issues were raised during the course of these reviews.

Assessing the Human Health Risks of Trichloroethylene identifies and assesses the key scientific issues relevant to analyzing the human health risks of trichloroethylene, considering pertinent toxicologic, epidemiologic, population susceptibility, and other available information, including relevant published scientific literature, EPA's 2001 draft health risk assessment of trichloroethylene, scientific and technical comments received by EPA from public and private sources, and additional relevant information to be provided by the sponsoring agencies. This report highlights issues critical to the development of an objective, realistic, and scientifically balanced trichloroethylene health risk assessment.

Guidance for hazard characterization of trichloroethylene is presented in Chapters 2 through 10. Chapter 2 provides guidance for evaluating large sets of epidemiologic data. In Chapter 3, the committee applies this guidance as an example in its evaluation of the epidemiologic data on trichloroethylene and kidney cancer, and this example should help guide evaluations of other cancer risks. Chapter 3 also assesses new information on the kidney toxicity of trichloroethylene and its metabolites and potential modes of action. Chapters 4, 5, 6, 7, and 8 evaluate the key issues regarding liver toxicity and cancer, reproductive and developmental toxicity, neurotoxicity, respiratory tract toxicity and cancer, and immunotoxicity, respectively. However, the committee's review focused on mode-of-action information to understand how trichloroethylene might affect certain processes differently in different species. Chapter 9 discusses susceptibility to trichloroethylene and its metabolites, and Chapter 10 describes important factors in considering trichloroethylene in mixtures. Physiologically based pharmacokinetic models are evaluated in Chapter 11, and guidance is provided on future directions for model development. Finally, Chapter 12 considers issues related to dose-response assessment and quantitative assessment of risk.

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