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Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report (2007)

Chapter: Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research

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Suggested Citation:"Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
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B
Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research

Hyatt Regency San Francisco Airport

11333 Bayshore Highway

Burlingame, CA 94010


Thursday, September 28, 2006

The Regency Ballroom Salons B&C

8:00 a.m.

WELCOME AND INTRODUCTIONS

 

Linda Giudice

Committee Chair

Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences

The Robert B. Jaffe, M.D. Endowed Chair in the Reproductive Sciences

University of California, San Francisco

 

Zach Hall

President

California Institute for Regenerative Medicine

Suggested Citation:"Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
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8:15 a.m.

OVERVIEW AND HISTORICAL PERSPECTIVE

 

Linda Giudice

Committee Chair

Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences

The Robert B. Jaffe, M.D. Endowed Chair in the Reproductive Sciences

University of California, San Francisco

Session I

Moderator: Joe Leigh Simpson

9:00 a.m.

OVARIAN HYPERSTIMULATION SYNDROME

 

Marcelle Cedars

Director

Division of Reproductive Endocrinology and Infertility

University of California, San Francisco

9:30 a.m.

SURGICAL RISKS

 

Ana Murphy

Brooks Professor and Chair

Department of Obstetrics and Gynecology

Medical College of Georgia

9:50 a.m.

ANESTHETIC RISKS

 

Lawrence Tsen

Associate Professor in Anesthesia

Harvard Medical School

Director of Anesthesia

Center for Reproductive Medicine

Brigham and Women’s Hospital

Suggested Citation:"Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×

10:10 a.m.

PANEL DISCUSSION

 

Panel will include all Session I speakers, plus Kurt Thomas Barnhart (Associate Professor, Department of Obstetrics and Gynecology and Epidemiology, and Director Center for Clinical Research on Women’s Health, University of Pennsylvania), as an invited discussant.

10:45 a.m.

BREAK

Session II

Moderator: Bernard Harlow

11:10 a.m.

PSYCHOLOGICAL RISKS

 

Susan Klock

Professor

Departments of Obstetrics and Gynecology and Psychiatry

Northwestern University Medical School

11:35 a.m.

CANCER RISKS

 

Roberta Ness

Professor and Chair

Department of Epidemiology

University of Pittsburgh

12:05 p.m.

PANEL DISCUSSION

 

Panel will include all Session II speakers, plus John Collins (Professor Emeritus, Department of Obstetrics and Gynecology, McMaster University, Hamilton), as an invited discussant

12:30 p.m.

LUNCH

Suggested Citation:"Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×

Session III

Moderator: Catherine Racowsky

1:30 p.m.

FUTURE FERTILITY

 

Nicholas Cataldo

Formerly Assistant Professor

Department of Obstetrics and Gynecology Stanford University

2:00 p.m.

SIMILARITIES AND DIFFERENCES IN THE PROCESS OF OOCYTE DONATION FOR CLINICAL TREATMENT VERSUS RESEARCH

 

Zev Rosenwaks

Director, Revlon Distinguished Professor of Reproductive Medicine

The Center for Reproductive Medicine and Infertility

Department of Obstetrics/Gynecology

Cornell University

2:30 p.m.

PANEL DISCUSSION

 

Panel will include all Session III speakers, plus David S. Guzick (Dean, University of Rochester School of Medicine and Dentistry), as an invited discussant

3:00 p.m.

BREAK

Suggested Citation:"Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×

Session IV

Panel Discussion with All Speakers

3:15 p.m.

SYNTHESIS AND REVIEW: CURRENT KNOWLEDGE, GAPS, HOW TO AVOID RISKS, FUTURE CONSIDERATIONS

 

Linda Giudice

Committee Chair

Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences

The Robert B. Jaffe, MD Endowed Chair in the Reproductive Sciences

University of California, San Francisco

4:15 p.m.

GENERAL DISCUSSION WITH AUDIENCE

 

Linda Giudice

Committee Chair

Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences

The Robert B. Jaffe, MD Endowed Chair in the Reproductive Sciences

University of California, San Francisco

5:30 p.m.

ADJOURN

Suggested Citation:"Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×

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Suggested Citation:"Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
Page 67
Suggested Citation:"Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
Page 68
Suggested Citation:"Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
Page 69
Suggested Citation:"Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
Page 70
Suggested Citation:"Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
Page 71
Suggested Citation:"Appendix B Public Workshop on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research." Institute of Medicine and National Research Council. 2007. Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research: Workshop Report. Washington, DC: The National Academies Press. doi: 10.17226/11832.
×
Page 72
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It is widely understood that stem cell treatments have the potential to revolutionize medicine. Because of this potential, in 2004 California voters approved Proposition 71 to set up a 10-year, $3 billion program to fund research on stem cells. Under the direction of the California Institute for Regenerative Medicine, this program will pay to build facilities for stem cell research and will fund doctors and scientists to carry out research with the ultimate goal of helping to develop therapies based on stem cells.

For this research to move forward, however, will require a steady supply of stem cells, particularly human embryonic stem cells. Those stem cells are collected from developing human embryos created from eggs—or oocytes—harvested from the ovaries of female donors. Thus much of the promise of stem cells depends on women choosing to donate oocytes to the research effort.

The oocyte donation process is not without risk, however. Donors are given doses of hormones to trigger the production of more eggs than would normally be produced, and this hormone treatment can have various side effects. Once the eggs have matured in the ovary, they must be retrieved via a surgical procedure that is typically performed under anesthesia, and both the surgery and the anesthesia carry their own risks. Furthermore, given the very personal nature of egg donation, the experience may carry psychological risks for some women as well.

With this in mind, in 2006 the California Institute for Regenerative Medicine contracted with the National Academies to organize a workshop that would bring together experts from various areas to speak about the potential risks of oocyte donation and to summarize what is known and what needs to be known about this topic. The Committee on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research was formed to plan the workshop, which was held in San Francisco on September 28, 2006. This report is a summary and synthesis of that workshop.

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