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2007 Amendments The National Academies’ Guidelines for Human Embryonic Stem Cell Research Appendix B Committee Biographical Sketches CO-CHAIRS R. Alta Charo, J.D., is the Warren P. Knowles Professor of Law and Bioethics at the University of Wisconsin–Madison, on the faculties of both the Law School and Medical School, and, in 2006, was Visiting Professor of Law at the University of California, Berkeley, Boalt Hall School of Law. Professor Charo is the author of nearly 100 articles, book chapters, and government reports on topics including voting rights, environmental law, family planning and abortion law, medical genetics law, reproductive technology policy, science policy, and medical ethics. Professor Charo is a member of the boards of the Alan Guttmacher Institute and the Foundation for Genetic Medicine, a member of the National Medical Advisory Committee of the Planned Parenthood Federation of America, and a member of the ethics advisory boards of the International Society for Stem Cell Research, the Juvenile Diabetes Research Foundation and WiCell. In 2005, she was appointed to the ethics standards working group of the California Institute for Regenerative Medicine and was elected as a fellow of the Wisconsin Academy of Sciences, Arts, and Letters. In 1994, Professor Charo served on the NIH Human Embryo Research Panel, and from 1996 to 2001 she was a member of the presidential National Bioethics Advisory Commission where she participated in drafting its reports on Cloning Human Beings (1997); Research Involving Persons with Mental Disorders That May Affect
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2007 Amendments The National Academies’ Guidelines for Human Embryonic Stem Cell Research Decisionmaking Capacity (1998); Research Involving Human Biological Materials: Ethical Issues and Policy Guidance (1999); Ethical Issues in Human Stem Cell Research (1999); Ethical and Policy Issues in International Research: Clinical Trials in Developing Countries, and Ethical and Policy Issues in Research Involving Human Participants (2001). Since 2001, she has been a member of the National Academies’ Board on Life Sciences and since 2006, she has been a member of the Institute of Medicine’s Board on Population Health and Public Health Practices. Professor Charo was elected to the Institute of Medicine in 2006. Richard O. Hynes, Ph.D., is the Daniel K. Ludwig Professor for Cancer Research at the MIT Center for Cancer Research and Department of Biology, and a Howard Hughes Medical Institute investigator. He was formerly head of the Biology Department and then director of the Center for Cancer Research at MIT. His research focuses on fibronectins and integrins and the molecular basis of cellular adhesion, both in normal development and in pathological situations, such as cancer, thrombosis, and inflammation. Dr. Hynes’ current interests are cancer invasion and metastasis, angiogenesis, and animal models of human disease states. He is a member of the National Academy of Sciences and the Institute of Medicine and is a Fellow of the Royal Society of London and the American Academy of Arts and Sciences. In 1997, he received the Gairdner International Foundation Award. In 2000, he served as president of the American Society for Cell Biology and testified before Congress about the need for federal support and oversight of embryonic stem cell research. He co-chaired the 2005 National Academies’ Guidelines for Human Embryonic Stem Cell Research. MEMBERS Eli Y. Adashi, M.D., M.S., FACOG, is currently the Dean of Medicine and Biological Sciences and the Frank L. Day Professor of Biology, the Warren Alpert Medical School of Brown University. Previously, Dr. Adashi served as the professor and chair of the Department of Obstetrics and Gynecology at the University of Utah Health Sciences Center. Dr. Adashi is a member of the Institute of Medicine of the National Academies, a member of the Association of American Physicians, and a fellow of the American Association for the Advancement of Science. Dr. Adashi is a former member of the Advisory Council of the National Institute of Child Health and Human Development and a former president of the Society for Reproductive Endo-
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2007 Amendments The National Academies’ Guidelines for Human Embryonic Stem Cell Research crinologists, the Society for Gynecologic Investigation, and the American Gynecological and Obstetrical Society. Dr. Adashi is also a former examiner and director of the Division of Reproductive Endocrinology of the American Board of Obstetrics and Gynecology. Finally, Dr. Adashi is a founding member and treasurer and, more recently, chair of the advisory committee of the Geneva-based Bertarelli Foundation, dedicated to promoting the welfare of the infertile couple and to addressing the current “epidemic” of high-order multiple gestations. Brigid L.M. Hogan, Ph.D., is the George Barth Geller Professor and Chair of the Department of Cell Biology, Duke University Medical Center. Prior to joining Duke, Dr. Hogan was an Investigator of the Howard Hughes Medical Institute and Hortense B. Ingram Professor in the Department of Cell Biology at Vanderbilt University Medical Center. Dr. Hogan earned her Ph.D. in Biochemistry at the University of Cambridge. After completing her Ph.D. she was a postdoctoral fellow in the Department of Biology at MIT. Before moving to the United States in 1988, Dr. Hogan was head of the Molecular Embryology Laboratory at the National Institute for Medical Research in London. Her research focuses on the genetic control of embryonic development and morphogenesis, using the mouse as a model system. Her laboratory developed methods for deriving mouse pluripotential embryonic germ (EG) cell lines. She was Co-Chair for Science of the 1994 NIH Human Embryo Research Panel and a member of the 2001/2002 National Academies’ Panel on Scientific and Medical Aspects of Human Cloning. Within the past few years, Dr. Hogan has been elected to the Royal Society of London, the American Academy of Arts and Sciences, the Institute of Medicine, and the National Academy of Sciences. Marcia Imbrescia is the current owner of Peartree Design, a landscape design firm, and was previously the media director for Drumbeater, a high-technology advertising agency. She holds B.A. degrees in marketing and journalism, and a graduate certificate in landscape design. Ms. Imbrescia has a passion for health advocacy and helping people with illness and disability. She is a member of the Board of Trustees of the Arthritis Foundation (AF), for which she has participated as a volunteer at the chapter and national levels. She served as member (1996–1998, 2001) and chairperson (2002–2003) of AF’s American Juvenile Arthritis Organization. In 1992, she received the Volunteer of the Year Award from the Massachusetts Chapter of AF. Her volunteer efforts include program development, conference planning, public speaking, fundraising, and advocacy. She served on the
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2007 Amendments The National Academies’ Guidelines for Human Embryonic Stem Cell Research National Academies’ Committee on Guidelines for Human Embryonic Stem Cell Research in 2004–2005. Terry Magnuson, Ph.D., is Sarah Graham Kenan Professor and chair of the Department of Genetics at the University of North Carolina. He also directs the Carolina Center for Genome Sciences, and is the program director of cancer genetics at the Lineberger Comprehensive Cancer Center. Dr. Magnuson’s research interests include mammalian genetics, genomics, and development. His laboratory has developed a high-throughput system to study the effects of mutations on mouse development with mouse embryonic stem cells. He is particularly interested in the role of chromatin remodeling complexes in processes such as autosomal imprinting, X-inactivation, and anterior-posterior patterning of axial structures in mammals. He is a member of the Board of Directors of the Genetics Society of America and of the Society for Developmental Biology. Linda B. Miller, OTR, M.S. in Hospital Administration, is President of the Washington, D.C.-based Volunteer Trustees Foundation, a consortium of not-for-profit hospital governing boards. She has extensive experience in trustee education, advocacy, and the legal, ethical, and policy issues facing voluntary health care institutions. Recently, she has worked closely with the states’ attorneys general in developing guidelines for protecting the community interest in the sale and conversion of nonprofit hospitals, as well as in designing models for practice and legal oversight. She was elected to membership in the Institute of Medicine in 1997. Ms. Miller has been a frequent speaker on health policy issues and has been published extensively in both the medical and popular press, including the New England Journal of Medicine, Health Affairs, USA Today, the Washington Post, and New York Times, among others. She served as a Special Assistant to the Secretary of Health, Education and Welfare (now HHS) and on numerous health-related policy councils and advisory committees, including the National Institutes of Health’s Consensus Panel on Liver Transplantation and, most recently, the Institute of Medicine’s Committee on Spinal Cord Injury. Ms. Miller currently serves on the Advisory Board of the University of Louisville-based Institute for Cellular Therapeutics, headed by Dr. Suzanne Ildstad, which does research in adult bone marrow transplant, and has been a member of several academic and health care institutions’ board of governors, including Blythedale Childrens Hospital in New York, Capital Hospice in the national capital region, and Cornell University’s Alumni Council, among others.
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2007 Amendments The National Academies’ Guidelines for Human Embryonic Stem Cell Research Jonathan D. Moreno, Ph.D., is the David and Lyn Silfen University Professor at the University of Pennsylvania. Until 2007, he was the Emily Davie and Joseph S. Kornfeld Professor of Biomedical Ethics at the University of Virginia where he also directed the Center for Biomedical Ethics. Dr. Moreno is a member of the Institute of Medicine of the National Academies. He is also a bioethics advisor for the Howard Hughes Medical Institute, a faculty affiliate of the Kennedy Institute of Ethics at Georgetown University, and a Fellow of the Hastings Center. During 1995–1996 he was Senior Policy and Research Analyst for the President’s Advisory Committee on Human Radiation Experiments and during 1998–2000 was a senior consultant for the National Bioethics Advisory Commission. He co-chaired the 2005 National Academies’ Committee on Guidelines for Human Embryonic Stem Cell Research and is a consultant to the Ethical, Social, and Cultural Program of the Bill & Melinda Gates Foundation Grand Challenges in Global Health initiative, for ethical and regulatory issues regarding stem cell research in China. Stuart H. Orkin,1 M.D., is the David G. Nathan Professor of Pediatrics at Harvard Medical School, Chair of the Department of Pediatric Onocology at the Dana-Farber Cancer Institute, and an Investigator with the Howard Hughes Medical Institute. His laboratory utilizes multidisciplinary approaches to understand how mammalian cells choose specific fates and how mutations in important transcriptional regulators lead to developmental defects or malignancy. Recent and ongoing work falls into several overlapping areas, including study of essential hematopoietic transcription factors, the genetic pathogenesis of two forms of leukemia, and whether some of the lessons of hematopoiesis may be applied to consideration of the pathogenesis of solid tumors. Finally, the fundamental properties of stem cells—pluripotency and self-renewal—are being addressed from a biochemical perspective in mouse embryonic stem (ES) cells. In the future, his laboratory will pursue the functions of the associated proteins in order to unravel the biochemistry of ES fate specification. This strategy may ultimately suggest how directed manipulation of somatic cells to an ES cell fate might be achieved. Pilar N. Ossorio, Ph.D., J.D., is Associate Professor of Law and Bioethics at the University of Wisconsin–Madison, and Program Faculty in the Graduate 1 Resigned from committee effective December 18, 2006.
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2007 Amendments The National Academies’ Guidelines for Human Embryonic Stem Cell Research Program in Population Health at UW. Prior to taking her position at UW, she was Director of the Genetics Section at the Institute for Ethics at the American Medical Association, and taught as an adjunct faculty member at the University of Chicago Law School. For the 2006 calendar year, Professor Ossorio was a visiting professor of law at the University of California, Berkeley, Boalt Hall School of Law. Dr. Ossorio received her Ph.D. in Microbiology and Immunology in 1990 from Stanford University. She went on to complete a postdoctoral fellowship in cell biology at Yale University School of Medicine. Throughout the early 1990s, Dr. Ossorio also worked as a consultant for the federal program on the Ethical, Legal, and Social Implications (ELSI) of the Human Genome Project, and in 1994, she took a full-time position with the Department of Energy’s ELSI program. In 1993, she served on the Ethics Working Group for President Clinton’s Health Care Reform Task Force. Dr. Ossorio received her J.D. from the University of California at Berkeley School of Law (Boalt Hall) in 1997. While at Boalt she was elected to the legal honor society Order of the Coif and received several awards for outstanding legal scholarship. Dr. Ossorio is a fellow of the American Association for the Advancement of Science (AAAS), on the editorial board of the American Journal of Bioethics, an advisor to NHGRI on ethical issues in large-scale sequencing, and a member of UW’s institutional review board for health sciences research. She is a past member of AAAS’s Committee on Scientific Freedom and Responsibility, a past member of the National Cancer Policy Board (Institute of Medicine), and has been a member or chair of several working groups on genetics and ethics. She has published scholarly articles in bioethics, law, and molecular biology. E. Albert Reece, M.D., Ph.D., is currently Dean of the University of Maryland School of Medicine and Vice President for Medical Affairs at the University of Maryland, Baltimore. Previously, he was Vice Chancellor and Dean of the University of Arkansas College of Medicine. Dr. Reece received his undergraduate degree from Long Island University, his M.D. (Magna Cum Laude) from New York University, his Ph.D. degree in biochemistry from the University of the West Indies, and his M.B.A. degree from the Fox School of Business and Management of Temple University. He completed a residency in OB/GYN at Columbia University–Presbyterian Hospital, and a fellowship in maternal-fetal medicine at Yale University School of Medicine. He served on the faculty at Yale for 10 years, and was the Chairman of the Department of Obstetrics, Gynecology, and Reproductive Sciences at
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2007 Amendments The National Academies’ Guidelines for Human Embryonic Stem Cell Research Temple University. Dr. Reece has published over 400 journal articles, book chapters, and abstracts, and 9 textbooks including Diabetes in Pregnancy; Medicine of the Fetus & Mother; and Fundamentals of Ultrasound in Obstetrics & Gynecology. He is an editor for the Journal of Maternal-Fetal Medicine and a reviewer for several other scientific journals. His research focuses on diabetes in pregnancy, birth defects, and prenatal diagnosis. Dr. Reece is a member of the Institute of Medicine. Joshua R. Sanes, Ph.D., is Professor of Molecular and Cellular Biology and the Paul J. Finnegan Family Director of the Center for Brain Science at Harvard University. He was previously Alumni Endowed Professor of Neurobiology at the Washington University School of Medicine. Dr. Sanes earned a B.A. in biochemistry and psychology at Yale and a Ph.D. in Neurobiology at Harvard. He studies the formation of the synapses that interconnect nerve cells, including pioneering work on the signals exchanged between nerve cells and their target muscles as new connections are made. He is also using the vertebrate visual system to examine how nerve cells develop and migrate to the right location in the body. He was elected a Fellow of the American Association for the Advancement of Science in 1992 and a member of the National Academy of Sciences in 2002. Harold T. Shapiro, Ph.D., is President Emeritus of both Princeton University and the University of Michigan and is currently Professor of Economics and Public Affairs at Princeton University. His research interests include bioethics, the social role of higher education, hospital/medical center administration, university administration, econometrics, statistics, and economics. Dr. Shapiro currently chairs the Board of Trustees of the Alfred P. Sloan Foundation, is presiding director for the Dow Chemical Company, and is a member of numerous boards including the Robert Wood Johnson Medical School, HCA, the Merck Vaccine Advisory Board, the Knight Foundation Commission on Intercollegiate Athletics, U.S. Olympic Committee, and the Stem Cell Institute of New Jersey. He is a former Chair of the Association of American Universities and the National Bioethics Advisory Committee and Vice Chair of the President’s Council of Advisors on Science and Technology. He has also served on the Board of Directors of the National Bureau of Economic Research, Inc. and the Board of Trustees of the Universities Research Association, Inc. He has chaired and served on numerous National Academies committees including the Committee on the Organizational Structure of the National Institutes of Health and the Committee on Particle Physics. Dr. Shapiro was awarded the 2006 American Association for the
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2007 Amendments The National Academies’ Guidelines for Human Embryonic Stem Cell Research Advancement of Science’s William D. Carey Lecture for his leadership in science policy. He earned a Ph.D. in economics from Princeton University and holds 14 honorary doctorates. John E. Wagner, Jr., M.D., is a professor of pediatrics at the University of Minnesota Medical School. He is the first recipient of the Children’s Cancer Research Fund/Hageboeck Family Chair in Pediatric Oncology and also holds the Variety Club Endowed Chair in Molecular and Cellular Therapy. He is the director of the division of Pediatric Hematology/Oncology and Bone Marrow Transplantation and Scientific Director of Clinical Research of the Stem Cell Institute. Dr. Wagner is a member of numerous societies, including the American Society of Hematology, the International Society of Experimental Hematology, and the American Society of Blood and Marrow Transplantation. He is a member of several honorary societies including Alpha Omega Alpha (1980), the American Society of Clinical Investigation (2000), and the Association of American Physicians (2006). Dr. Wagner holds a patent on the isolation of the pluripotential quiescent stem cell population. Dr. Wagner holds a B.A. in Biological Sciences and a B.A. in Psychology from the University of Delaware and an M.D. from Jefferson Medical College. Dr. Wagner’s research has focused on the development of novel cellular therapies for tissue repair and suppression of the immune response using subpopulations of neonatal umbilical cord blood and adult bone marrow and peripheral blood. Projects are funded by both NIH (P01 CA65493, Biology and Transplantation of the Human Stem Cell; and N01-HB-37164, Somatic Cell Therapeutics) and industry (ViaCell, Inc., on the transplantation of expanded umbilical cord blood hematopoietic stem cells; and Athersys, Inc., on the large-scale development of multipotent adult progenitor cells). In addition, Dr. Wagner pioneered the use of embryo selection to “create” a perfectly tissue matched stem cell donor in the treatment of genetic disease. Dr. Wagner has authored more than 180 articles and book chapters on the subject of hematopoietic stem cell transplantation. He currently co-chairs the Graft Sources and Manipulation Working Committee of the Center of the International Blood and Marrow Transplant Research, serves on the Scientific Board of Directors of the National Marrow Donor Program, and is a member of the Scientific and Medical Accountability Standards Working Group of the California Institute of Regenerative Medicine. Dr. Wagner has previously served as a member of the Institute of Medicine’s Committee on Establishing a National Cord Blood Stem Cell Banking Program.
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