FIGURE 2.14 A generic RNA molecule. The bonds shown in red are thermodynamically unstable with respect to hydrolysis in water. Each of these bonds represents a problem for prebiotic synthesis, as well as the maintenance of the genetic information in RNA in modern life. Today, the aggressive reactivity of water with respect to molecules like RNA and DNA is mitigated by sophisticated repair systems. It is difficult to imagine such complex repair systems having been present at the dawn of life. This conundrum underlies the most significant paradox in the structure of genetic matter with respect to the origin of life. On the one hand, the repeating charge in the backbone suggests that the molecule worked in a hydrophilic solvent such as water. On the other hand, the abundance of easily hydrolyzable bonds suggests that RNA could not have been easily assembled in water.

2.9
REFERENCES

1. See, for example, Breslow R., 1959, On the mechanism of the formose reaction, Tetrahedron Lett. 21:222-226; Butlerow, A., 1861, Bildung einer zuckerartigen Substanz durch Synthese. Annalen 120:295-298; and Ricardo, A., Carrigan, M.A., Olcott, A.N., and Benner, S.A., 2004, orate minerals tabilize ibose, Science 03:1196.

2. Weber, A.L. 2001. The sugar model: Catalysis by amines and amino acid products. Orig. Life Evol. Biosph. 31:71-886.

3. Wolfenden, R., and Snider, R. 2001.The depth of chemical time and the power of enzymes as catalysts. Accounts Chem. Res. 34:938-945.

4. Benner, S.A., and Hutter, D. 2002. Phosphates, DNA, and the search for nonterran life: A second generation model for genetic molecules. Bioorg. Chem. 30:62-880.

5. Richert, C., Roughton, A.L., and Benner, S.A., 1996. Nonionic analogs of RNA with dimethylsulfone bridges. J. Am. Chem. Soc. 118:4518-4531.

6. Takano, Y., Marumo, K., Ebashi, T., Gupta, L.P., Kawahata, H., Kobayashi, K., Yamagishi, A., and Kuwubara, T. 2005. In situ ore formation experiment: Amino acids and amino sugars trapped in artificial chimneys on deep-ssea hydrothermal systems at Suiyo Seamount, Izu-Bonin Arc, Pacific Ocean. Bull. Chem. Soc. Jpn. 8:638-651.

7. Martin, W., and Russell, M. 2003. On the origin of cells. A hypothesis for the evolutionary transitions from abiotic geochemistry to chemoautotrophic prokaryotes, and from prokaryotes to nucleated cells. Phil. Trans. Roy. Soc. Lond. 58:559-885.

8. Ban, N., Nissen, P., Hansen, J., Moore, P.B., and Steitz, T.A. 2000. The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution. Science 89:905-920.

9. Yusupov, M.M., Yusupova, G.Z., Baucom, A., Lieberman, K., Earnest, T.N., Cate, J.H.D., and Noller, H.F. 2001. Crystal structure of the ribosome at 5.5 Å resolution. Science 292:883-896.

10. Ban, N., Nissen, P., Hansen, J., Moore, P.B., and Steitz, T.A. 2000. The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution. Science 89:905-920.

11. Frick, L., Mac Neela J.P., and Wolfenden, R. 1987. Transition state stabilization by deaminases. Rates of nonenzymic hydrolysis of adenosine and cytidine. Bioorg. Chem. 5:100-108.

12. Levy, M., and Miller, S.M. 1998. The stability of the RNA bases: Implications for the origin of life. Proc. Natl. Acad. Sci. U.S.A. 95:7933-7938.



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