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OCR for page 293
B
Workshop Agenda
Autism and the Environment:
Challenges and Opportunities for Research
Wednesday, April 18, 2007
Keck Building, Room 100
500 Fifth Street, N.W.
Washington, DC 20001
Workshop Objectives
• Discuss the most promising scientific opportunities for
improving the understanding of potential environmental factors
in autism.
• Discuss what scientific tools and technologies are available,
what interdisciplinary research approaches are needed, and what
further infrastructure investments will be necessary in the short
and long term to be able to explore potential relationships
between autism and environmental factors.
• Explore potential partnerships needed to support and conduct
autism research.
8:00 a.m. Welcome, Introductions, and Workshop Objectives
ALAN LESHNER
Workshop and Forum Chair
Chief Executive Officer, AAAS
Executive Publisher, Science
293
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294 AUTISM AND THE ENVIRONMENT
8:05 a.m. Charge to Workshop Participants
WILLIAM RAUB
Science Advisor to the Secretary
Department of Health and Human Services
8:15 a.m. Perspectives of the Advocacy Community
LAURA BONO
Workshop Planning Committee Member
Board Member
National Autism Association
SESSION I: AUTISM—THE CLINICAL PROBLEM: “WHAT
DO WE KNOW? WHAT DO WE NEED?”
Session Objective: Describe the problem and discuss how environmental
factors may impact a developmental disorder like autism. Identify what
standards of evidence are needed to move forward.
SARAH SPENCE, Session Chair
Staff Clinician
Pediatrics and Developmental Neuropsychiatry Branch
National Institute of Mental Health, NIH
8:25 a.m. Clinical Overview: How Can the Clinical Manifestations of
Autism Shed Light on Potential Environmental Etiologies?
SUSAN SWEDO
Senior Investigator
Pediatrics and Developmental Neuropsychiatry Branch
National Institute of Mental Health, NIH
8:45 a.m. Genes and the Environment: How May Genetics Be Used to
Inform Research Searching for Potential Environmental
Triggers?
PATRICK LEVITT
Director
Vanderbilt Kennedy Center for Research on Human
Development, Vanderbilt University
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295
APPENDIX B
9:05 a.m. How May Environmental Factors Impact Potential
Mechanisms in Humans?
ISAAC PESSAH
Director
Children’s Center for Environmental Health and
Disease Prevention
University of California–Davis M.I.N.D. Institute
9:25 a.m. Defining Autism: Biomarkers and Other Research Tools
MARTHA HERBERT
Assistant Professor of Neurology
Harvard Medical School
9:45 a.m. Discussion
SARAH SPENCE, Session Chair
Staff Clinician
Pediatrics and Developmental Neuropsychiatry Branch
National Institute of Mental Health, NIH
10:20 a.m. BREAK
SESSION II: LESSONS LEARNED FROM
OTHER DISORDERS:
“STANDARDS OF EVIDENCE”
Session Objective: Explore how the autism field may employ approaches
and strategies used by other fields. What has been learned from research
that has examined environmental exposure effects on other disorders?
DAVID SCHWARTZ, Session Chair
Director
National Institute of Environmental Health Sciences,
NIH
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296 AUTISM AND THE ENVIRONMENT
10:35 a.m. Environmental Toxicants and Neurodevelopment
PHILIP LANDRIGAN
Chair of Community and Preventive Medicine
Mt. Sinai School of Medicine
10:55 a.m. Prenatal Starvation and Schizophrenia
EZRA SUSSER
Gelman Professor and Chair of Epidemiology
Mailman School of Public Health
Professor of Psychiatry
Columbia University and New York State Psychiatric
Institute
11:15 a.m. Asthma
FERNANDO MARTINEZ
Swift-McNear Professor of Pediatrics
Director, Arizona Respiratory Center
University of Arizona
11:35 a.m. Discussion
DAVID SCHWARTZ, Session Chair
Director
National Institute of Environmental Health Sciences,
NIH
12:10 p.m. LUNCH
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297
APPENDIX B
SESSION III: ENVIRONMENT AND BIOLOGY I:
WHAT ARE THE TOOLS FOR AUTISM—
WHAT DO WE HAVE? WHAT DO WE NEED?
Session Objective: Review how environmental factors can impact
fundamental biological processes. Examine the resources available, and
needed, to examine susceptibility to environmental agents.
PATRICK LEVITT, Session Chair
Director
Vanderbilt Kennedy Center for Research on Human
Development, Vanderbilt University
1:00 p.m. How May Environmental Factors Impact Potential
Molecular and Epigenetic Mechanisms?
ARTHUR BEAUDET
Professor and Chair
Department of Molecular and Human Genetics
Baylor College of Medicine
1:20 p.m. How May Environmental Factors Impact Potential Cell-
Based Mechanisms?
MARK NOBLE
Professor of Genetics
University of Rochester Medical Center
1:40 p.m. How May Animal Models Be Used to Examine Potential
Environmental-Based Mechanisms?
THEODORE SLOTKIN
Professor of Pharmacology and Cancer Biology
Duke University Medical Center
2:00 p.m. BREAK
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298 AUTISM AND THE ENVIRONMENT
2:20 p.m. Autism, Infection, and Immunity: What Are the Potential
Causative Environmental Factors and How Can They Be
Identified and Prioritized?
W. IAN LIPKIN
Director, Columbia Center for Infection and Immunity
Mailman School of Public Health of Columbia
University, and
Scientific Director, Northeast Biodefense Center
2:40 p.m. Environmental Factors and Oxidative Stress: How May
Oxidative Stress Impact the Biology of Autism? What
Factors May Be Causing This Outcome?
S. JILL JAMES
Professor of Pediatrics
University of Arkansas for Medical Sciences
3:00 p.m. Discussion
PATRICK LEVITT, Session Chair
Director
Vanderbilt Kennedy Center for Research on Human
Development, Vanderbilt University
SESSION IV: NEW APPROACHES AND DISCUSSION WITH
WORKSHOP ATTENDEES
4:20 p.m. Discussion with Meeting Participants and Audience
ALAN LESHNER, Moderator
Workshop and Forum Chair
Chief Executive Officer, AAAS
Executive Publisher, Science
5:30 p.m. ADJOURN
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299
APPENDIX B
Thursday, April 19, 2007
Keck Building, Room 100
500 Fifth Street, N.W.
Washington, DC 20001
SESSION V: ENVIRONMENTAL EPIDEMIOLOGY—
UTILIZING POPULATION-BASED STUDIES TO ISOLATE
THE ENVIRONMENTAL CAUSES OF AUTISM
Session Objective: Discuss and identify what resources are available and
what is needed to help frame future directions for environmental
epidemiology studies.
HENRY FALK, Session Chair
Director
Coordinating Center for Environmental Health and
Injury Prevention, Centers for Disease Control and
Prevention
8:00 a.m. Environmental Epidemiology Studies: New Techniques and
Technologies to Use Epidemiology to Find Environmental
Triggers
IRVA HERTZ-PICCIOTTO
Professor of Epidemiology and Preventive Medicine
University of California–Davis
8:20 a.m. Environmental Exposures in Autism: International Studies
CRAIG NEWSCHAFFER
Professor and Chairman of Epidemiology and
Biostatistics
Drexel University
8:40 a.m. Environmental Epidemiology Studies: CADDRE
DIANA SCHENDEL
National Center on Birth Defects and Developmental
Disabilities
Centers for Disease Control and Prevention
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300 AUTISM AND THE ENVIRONMENT
9:00 a.m. Prenatal and Perinatal Exposures
ALLEN WILCOX
Chief
Epidemiology Branch
National Institute of Environmental Health Sciences,
NIH
9:20 a.m. Discussion
HENRY FALK, Session Chair
Director
Coordinating Center for Environmental Health and
Injury Prevention, Centers for Disease Control and
Prevention
SESSION VI: TECHNOLOGY AND INFRASTRUCTURE
NEEDS FOR FUTURE RESEARCH
Session Objective: Discuss and identify what tools are currently
available to assess environmental exposure, and what additional
scientific tools and technologies are needed in the short and long term.
HENRY FALK, Session Chair
Director
Coordinating Center for Environmental Health and
Injury Prevention, Centers for Disease Control and
Prevention
9:50 a.m. CDC Environmental Health Lab—Body Burden Measures
LARRY NEEDHAM
Chief
Organic Analytical Toxicology Branch
National Center for Environmental Health, CDC
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301
APPENDIX B
10:10 a.m. Personalized Environmental Sensors
DAVID WALT
Professor of Chemistry
Tufts University
10:30 a.m. Discussion
HENRY FALK, Session Chair
Director
Coordinating Center for Environmental Health and
Injury Prevention, Centers for Disease Control and
Prevention
SESSION VII: FUTURE RESEARCH DIRECTIONS—
DISCUSSION WITH WORKSHOP SPEAKERS
Session Objective: Discuss what a research agenda for autism and the
environment might look like.
11:00 a.m. FERNANDO MARTINEZ
Swift-McNear Professor of Pediatrics
Director, Arizona Respiratory Center
University of Arizona
ISAAC PESSAH
Director, Children’s Center for Environmental Health
and Disease Prevention
University of California–Davis M.I.N.D. Institute
12:30 p.m. LUNCH
SESSION VIII: PUBLIC–PRIVATE PARTNERSHIPS
Session Objective: Identify the unique strengths that the public and
private sectors provide to the autism research. Discuss how each of these
sectors can most effectively complement each other’s efforts.
ALAN LESHNER, Moderator
Workshop and Forum Chair
Chief Executive Officer, AAAS
Executive Publisher, Science
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302 AUTISM AND THE ENVIRONMENT
1:00 p.m. Panel Discussion
SALLIE BERNARD
Board Member, Autism Speaks
Cofounder, SafeMinds
HENRY FALK
Director
Coordinating Center for Environmental Health and
Injury Prevention, Centers for Disease Control and
Prevention
GARY GOLDSTEIN
Chair, Autism Speaks Scientific Affairs Committee
President and Chief Executive Officer, Kennedy
Krieger Institute
TOM INSEL
Director
National Institute of Mental Health, NIH
LYN REDWOOD
Board Member and Science Committee Chair
National Autism Association
DAVID SCHWARTZ
Director
National Institute of Environmental Health Sciences,
NIH
1:45 p.m. General Panel Discussion
ALAN LESHNER, Moderator
Workshop and Forum Chair
Chief Executive Officer, AAAS
Executive Publisher, Science
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303
APPENDIX B
SESSION IX: DISCUSSION WITH MEETING PARTICIPANTS
AND AUDIENCE
2:15 p.m. ALAN LESHNER, Moderator
Workshop and Forum Chair
Chief Executive Officer, AAAS
Executive Publisher, Science
3:15 p.m. ADJOURN
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