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Review of Toxicologic and Radiologic Risks to Military Personnel from Exposure to Depleted Uranium During and After Combat (2008)
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Review of the Toxicologic and Radiologic Risks to Military Personnel from Exposures to Depleted Uranium During and After Combat

References

AEPI (U.S. Army Environmental Policy Institute). 1995. Health and Environmental Consequences of Depleted Uranium Use in the US Army. U.S. Army Environmental Policy Institute, Atlanta, GA [online]. Available: http://www.fas.org/man/dod-101/sys/land/docs/techreport.html [accessed July 9, 2007].

Archer, V.E., J.K. Wagoner, and F.E. Lundin Jr. 1973. Cancer mortality among uranium mill workers. J. Occup. Med.15(1):11-14.

Arfsten, D.P., M. Bekkedal, E.R. Wilfong, J. Rossi, III, K.A. Grasman, L.B. Healey, J.M. Rutkiewicz, E.W. Johnson, A.R. Thitoff, A.E. Jung, S.R. Lohrke, D.J. Schaeffer, and K.R. Still. 2005. Study of the reproductive effects in rats surgically implanted with depleted uranium for up to 90 days. J. Toxicol. Environ. Health A 68(11-12):967-997.

Arfsten, D.P., D.J. Schaeffer, E.W. Johnson, R.J. Cunningham, K.R. Still, and E.R. Wilfong. 2006. Evaluation of the effect of implanted depleted uranium on male reproductive success, sperm concentration, and sperm velocity. Environ. Res. 100(2): 205-215.

Arfsten, D.P., E.R. Wilfong, M. Bekkedal, E.W. Johnson, S.M. McInurf, J.S. Egers, D.J. Schaeffer, and K.R. Still. 2007. Evaluation of the effects of implanted depleted uranium (DU) pelletson adult rat behavior and toxicological endpoints. J. Toxicol. Environ. Health 70(23):1995-2010.

ATSDR (Agency for Toxic Substances and Disease Registry). 1999. Toxicological Profile for Uranium. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta, GA [online]. Available: http://www.atsdr.cdc.gov/toxprofiles/tp150.html [accessed July 9, 2007].

Autian, J., A.R. Singh, J.E. Turner, G.W. Hung, L.J. Nunez, and W.H. Lawrence. 1975. Carcinogenesis from polyurethans. Cancer Res. 35(6):1591-1596.

Bailey, M., and C. Marsh. 2001. Appendix 1. Exposures arising from the use of depleted uranium on the battlefield. Pp. 31-58 in The Health Hazards of Depleted Uranium Munitions, Part I. Policy Document 6/01. The Royal Society, London. May 22, 2001 [online]. Available: http://www.royalsoc.ac.uk/document.asp?tip=1&id=1431 [accessed July 12, 2007].

Barber, D.S., M.F. Ehrich, and B.S. Jortner. 2005. The effect of stress on the temporal and regional distribution of uranium in rat brain after acute uranyl acetate exposure. J. Toxicol. Environ. Health A 68(2):99-111.

Basset, S.H., A. Frenkel, N. Cedars, et al. 1948. The Excretion of Hexavalent Uranium Following Intravenous Administration. II. Studies on Human Subjects. USAEC report UR-37 (as cited in ATSDR 1999).

Beck, A.T., N. Epstein, G. Brown, and R.A. Steer. 1988. An inventory for measuring clinical anxiety: psychometric properties. J. Consult Clin. Psychol. 56(6):893-897.

Beck, A.T., R.A. Steer, and G.K. Brown. 1996. Manuel for the Beck Depression Inventory. San Antonio, TX: The Psychological Corporation.

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Review of the Toxicologic and Radiologic Risks to Military Personnel from Exposures to Depleted Uranium During and After Combat References AEPI (U.S. Army Environmental Policy Institute). 1995. Health and Environmental Consequences of Depleted Uranium Use in the US Army. U.S. Army Environmental Policy Institute, Atlanta, GA [online]. Available: http://www.fas.org/man/dod-101/sys/land/docs/techreport.html [accessed July 9, 2007]. Archer, V.E., J.K. Wagoner, and F.E. Lundin Jr. 1973. Cancer mortality among uranium mill workers. J. Occup. Med.15(1):11-14. Arfsten, D.P., M. Bekkedal, E.R. Wilfong, J. Rossi, III, K.A. Grasman, L.B. Healey, J.M. Rutkiewicz, E.W. Johnson, A.R. Thitoff, A.E. Jung, S.R. Lohrke, D.J. Schaeffer, and K.R. Still. 2005. Study of the reproductive effects in rats surgically implanted with depleted uranium for up to 90 days. J. Toxicol. Environ. Health A 68(11-12):967-997. Arfsten, D.P., D.J. Schaeffer, E.W. Johnson, R.J. Cunningham, K.R. Still, and E.R. Wilfong. 2006. Evaluation of the effect of implanted depleted uranium on male reproductive success, sperm concentration, and sperm velocity. Environ. Res. 100(2): 205-215. Arfsten, D.P., E.R. Wilfong, M. Bekkedal, E.W. Johnson, S.M. McInurf, J.S. Egers, D.J. Schaeffer, and K.R. Still. 2007. Evaluation of the effects of implanted depleted uranium (DU) pelletson adult rat behavior and toxicological endpoints. J. Toxicol. Environ. Health 70(23):1995-2010. ATSDR (Agency for Toxic Substances and Disease Registry). 1999. Toxicological Profile for Uranium. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta, GA [online]. Available: http://www.atsdr.cdc.gov/toxprofiles/tp150.html [accessed July 9, 2007]. Autian, J., A.R. Singh, J.E. Turner, G.W. Hung, L.J. Nunez, and W.H. Lawrence. 1975. Carcinogenesis from polyurethans. Cancer Res. 35(6):1591-1596. Bailey, M., and C. Marsh. 2001. Appendix 1. Exposures arising from the use of depleted uranium on the battlefield. Pp. 31-58 in The Health Hazards of Depleted Uranium Munitions, Part I. Policy Document 6/01. The Royal Society, London. May 22, 2001 [online]. Available: http://www.royalsoc.ac.uk/document.asp?tip=1&id=1431 [accessed July 12, 2007]. Barber, D.S., M.F. Ehrich, and B.S. Jortner. 2005. The effect of stress on the temporal and regional distribution of uranium in rat brain after acute uranyl acetate exposure. J. Toxicol. Environ. Health A 68(2):99-111. Basset, S.H., A. Frenkel, N. Cedars, et al. 1948. The Excretion of Hexavalent Uranium Following Intravenous Administration. II. Studies on Human Subjects. USAEC report UR-37 (as cited in ATSDR 1999). Beck, A.T., N. Epstein, G. Brown, and R.A. Steer. 1988. An inventory for measuring clinical anxiety: psychometric properties. J. Consult Clin. Psychol. 56(6):893-897. Beck, A.T., R.A. Steer, and G.K. Brown. 1996. Manuel for the Beck Depression Inventory. San Antonio, TX: The Psychological Corporation.

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Review of the Toxicologic and Radiologic Risks to Military Personnel from Exposures to Depleted Uranium During and After Combat Benson, K.A. 1998. Fetal development effects. Pp. 17-21 in Health Effects of Embedded Depleted Uranium Fragments, D.R. Livengood, ed. Report No. A987943. Special Publication 98-3. Bethesda, MD: Armed Forces Radiobiology Research Institute [online]. Available: http://www.afrri.usuhs.mil/www/outreach/reports/pdf/SP98-3.pdf [accessed July 12, 2007]. Benson, K.A., and S.A. McBride. 1997. Uranium levels in the fetus and placenta of female rats implanted with depleted uranium pellets prior to breeding. Toxicologist 36(1 Pt. 2):258. Beral, V., P. Fraser, L. Carpenter, M. Booth, A. Brown, and G. Rose. 1988. Mortality of employees of the Atomic Weapons Establishment. Br. Med. J. 297(6651):757-770. Berlin, M., and B. Rudell. 1986. Uranium. Pp. 623-637 in Handbook on the Toxicology of Metals, Vol. II, 2nd Ed., L. Friberg, G. Nordberg, and V. Vouk, eds. Amsterdam: Elsevier. Bernard, S.R., and E.G. Struxness. 1957. A Study of the Distribution and Excretion of Uranium in Man. ORNL-2304. Oak Ridge, TN: Oak Ridge National Laboratory. BIPM (Bureau International des Poids et Mesures). 1998. Le systéme international d’unités (SI), 7th Ed. Sevres: Bureau International des Poids et Mesures. Boback, M.W. 1975. A review of uranium excretion and clinical urinalysis data in accidental exposure cases. Pp. 225-243 in Conference Proceedings on Occupational Health Experience with Uranium, April 28-30, 1975, Arlington, VA. Document ERDA 93. Springfield VA: National Technical Information Service. Boice, J.D., Jr., W.L. Bigbee, M.T. Mumma, and W.J. Blot. 2003a. Cancer mortality in counties near two former nuclear processing facilities in Pennsylvania, 1950-1995. Health Phys. 85(6):691-700. Boice, J.D., Jr., W.L. Bigbee, M.T. Mumma, and W.J. Blot. 2003b. Cancer incidence in municipalities near two former nuclear materials processing facilities in Pennsylvania. Health Phys. 85(6):678-690. Boice, J.D., Jr., M. Mumma, S. Schweitzer, and W.J. Blot. 2003c. Cancer mortality in a Texas county with prior uranium mining and milling activities, 1950-2001. J. Radiol. Protect. 23(3):247-262. Bosque, M.A., J.L. Domingo, and J. Corbella. 1992. Embryotoxicity of uranium in mice. Variability with the day of exposure. Rev. Toxicol. 97:107-110. Bosque, M.A., J.L. Domingo, J.M. Llobet, and J. Corbella. 1993. Embryotoxicity and teratogenicity of uranium in mice following subcutaneous administration of uranyl acetate. Biol. Trace Elem. Res. 36(2):109-118. Brady, H.R., B.C. Kone, R.M. Brenner, and S.R. Gullans. 1989. Early effects of uranyl nitrate on respiration and K+ transport in rabbit proximal tubule. Kidney Int. 36(1): 27-34. Brand, K.G., K.H. Johnson, and L.C. Buoen. 1976. Foreign body tumorigenesis. CRC Crit. Rev. Toxicol. 4(4):353-394. BRH (U.S. Bureau of Radiological Health). 1970. Radiological Health Handbook, Rev. Ed. Publication No. 2016. Rockville, MD: U.S. Department of Health Education and Welfare, Public Health Service, Consumer Protection and Environmental Health Service. January 1970. Brown, D.P., and T. Bloom. 1987. Mortality Among Uranium Enrichment Workers. PB-87-188991/XAB. Cincinnati, OH: National Institute for Occupational Safety and Health. Bussy, C., P. Lestaevel, B. Dhieux, C. Amourette, F. Paquet, P. Gourmelon, and P. Houpert. 2006. Chronic ingestion of uranyl nitrate perturbs acetylcholinesterase activ-

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Review of the Toxicologic and Radiologic Risks to Military Personnel from Exposures to Depleted Uranium During and After Combat ity and monoamine metabolism in male rat brains. Neurotoxicology 27(2):245-252. Butterworth, A. 1955. Significance and value of uranium in urine analysis. Trans. Assoc. Ind. Med. Offrs 5:30-43 (as cited in ATSDR 1999). Carpenter, L.M., C.D. Higgins, A.J. Douglas, N.E. Maconochie, R.Z. Omar, P. Fraser, V. Beral, and P.G. Smith. 1998. Cancer mortality in relation to monitoring for radionuclide exposure in three UK nuclear industry workforces. Br. J. Cancer 78(9): 1224-1232. Carroll, M.F., and J.L. Tempte. 2000. Proteinuria in adults: a diagnostic approach. Am. Fam. Physician 62(6):1333-1340. Checkoway, H, R.M. Mathew, J.L. Hickey, C.M. Shy, R.L. Harris, E.W. Hunt, and G.T. Waldman. 1985. Mortality among workers in the Florida phosphate industry. I. Industry-wide cause-specific mortality patterns. J. Occup. Med. 27(12):885-892. Checkoway, H., N. Pearce, D.J. Crawford-Brown, and D.L. Cragle. 1988. Radiation doses and cause-specific mortality among workers at a nuclear materials fabrication plant. Am. J. Epidemiol. 127(2):255-266. Checkoway, H., N.J. Heyer, and P.A. Demers. 1996. An updated mortality follow-up study of Florida phosphate industry workers. Am. J. Ind. Med. 30(4):452-460. Chen, J., D.P. Meyerhof, and B.L. Tracy. 2004. Model results of kidney burdens from uranium intakes. Health Phys. 86(1):3-11. Chevari, S., and D. Likhner. 1968. Complex formation of natural uranium in blood [in Russian]. Med. Radiol. 13(8):53-57. Conrad, K., and J. Mehlhorn. 2000. Diagnostic and prognostic relevance of autoantibodies in uranium miners. Int. Arch. Allergy Immunol. 123(1):77-91. Cookfair, D.L., W. Beck, C. Shy, C. Lushbaugh, and C. Sowder. 1983. Lung cancer among workers at a uranium processing plant. Pp. 398-406 in Epidemiology Applied to Health Physics: Proceedings of the 16th Midyear Topical Meeting of the Health Physics Society, Jan. 9-13, 1983, Albuquerque, NM. Report DE83014383/ CONF-830101. Springfield, VA: National Technical Information Service, U.S. Department of Commerce. Cooper, J.R., G.N. Stradling, H. Smith, and S.E. Ham. 1982. The behaviour of uranium-233 oxide and uranyl-233 nitrate in rats. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 41(4):421-433. Coryell, V.H., and D.M. Stearns. 2006. Molecular analysis of hprt mutations generated in Chinese hamster ovary EM9 cells by uranyl acetate, by hydrogen peroxide and spontaneously. Mol. Carcinog. 45(1):60-72. Craft, E.S., A. Abu-Qare, M. Flaherty, M. Garofolo, H. Rincavage, and M. Abou-Donia. 2004. Depleted and natural uranium: Chemistry and toxicological effects. J. Toxicol. Environ. Health B Crit. Rev. 7(4):297-317. Cragle, D.L., R.W. McLain, J.R. Qualters, J.L. Hickey, G.S. Wilkinson, W.G. Tankersley, and C.C. Lushbaugh. 1988. Mortality among workers at a nuclear fuels production facility. Am. J. Ind. Med. 14(4):379-401. Cross, F.T., R.F. Palmer, R.H. Busch, R.E. Filipy, and B.O. Stuart. 1981a. Development of lesions in Syrian golden hamsters following exposure to radon daughters and uranium ore dusts. Health Phys. 41(1):135-153. Cross, F.T., R.E. Filipy, S.M. Loscutoff, P.J. Mihalko, R.F. Palmer, and R.H. Busch. 1981b. Histopathologic, Morphometric, and Physiologic Investigation of Lungs of Dogs Exposed to Uranium-Ore Dust. PNL-SA-9927. Richland, WA: Battelle Pacific Northwest Labs.

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Review of the Toxicologic and Radiologic Risks to Military Personnel from Exposures to Depleted Uranium During and After Combat de Rey, B.M., H.E. Lanfranchi, and R.L. Cabrini. 1983. Percutaneous absorption of uranium compounds. Environ. Res. 30(2):480-491. Derogatis, L.R. 1983. The Symptoms Checklist-90 Revised. Towson, MD: Clinical Psychometric Research. Diamond, G.L., and R.K. Zalups. 2005. Nephrotoxicology of uranium. Pp. 971-979 in Toxicology of the Kidney, 3rd Ed., J.B. Tarloff, and L.H. Lash, eds. Boca Raton: CRC Press. Diamond, G.L., P.E. Morrow, B.J. Panner, R.M. Gelein, and R.B. Baggs. 1989. Reversible uranyl fluoride nephrotoxicity in the Long Evans rat. Fundam. Appl. Toxicol. 13(1):65-78. Diaz Sylvester, P.L., R. López, A.M. Ubios, and R.L. Cabrini. 2002. Exposure to subcutaneously implanted uranium dioxide impairs bone formation. Arch. Environ. Health 57(4):320-325. DOD (U.S. Department of Defense). 2001. Information Paper: Depleted Uranium Environmental and Medical Surveillance in the Balkans [online]. Available: http://fhp.osd.mil/du/du_balkans/ [accessed July 6, 2007]. DOE (U.S. Department of Energy). 2004. Environmental Monitoring Results, Annual Site Environmental Report for Calendar Year 2003, Paducah Gaseous Diffusion Plant, Paducah, Kentucky., Vol. II. BJC/PAD-611/V2. Prepared by CDM Federal Services Inc., for Office of Environmental Management, U.S. Department of Energy [online]. Available: http://www.prs-llc.net/aser/2003%20ASER/2003%20ASER%20Data%20Volume.pdf [accessed July 9, 2007]. Domingo, J.L. 2001. Reproductive and developmental toxicity of natural and depleted uranium: A review. Reprod. Toxicol. 15(6):603-609. Domingo, J.L., J.M. Llobet, J.M. Tomás, and J. Corbella. 1987. Acute toxicity of uranium in rats and mice. Bull. Environ. Contam. Toxicol. 39(1):168-174. Domingo, J.L., A. Ortega, J.L. Paternain, and J. Corbella. 1989. Evaluation of the perinatal and postnatal effects of uranium in mice upon oral administration. Arch. Environ. Health 44(6):395-398. Dublineau, I., S. Grison, C. Linard, C. Baudelin, N. Dudoignon, M. Souidi, C. Marquette, F. Paquet, J. Aigueperse, and P. Gourmelon. 2006. Short-term effects of depleted uranium on immune status in rat intestine. J. Toxicol. Environ. Health A 69(17): 1613-1628. Dupree, E.A., D.L. Cragle, R.W. McLain, D.J. Crawford-Brown, and M.J. Teta. 1987. Mortality among workers at a uranium processing facility, the Linde Air Products Company Ceramics Plant, 1943-1949. Scand. J. Work Environ. Health. 13(2):100-107. Dupree, E.A., J.P. Watkins, J.N. Ingle, P.W. Wallace, C.M. West, and W.G. Tankersley. 1995. Uranium dust exposure and lung cancer risk in four uranium processing operations. Epidemiology 6(4):370-375. Dupree-Ellis, E., J. Watkins, J.N. Ingle, and J. Phillips. 2000. External radiation exposure and mortality in a cohort of uranium processing workers. Am. J. Epidemiol. 152(1):91-95. Durbin, P.W. 1984. Metabolic models for uranium. Pp. F1-F65 in Biokinetics and Analysis of Uranium in Man, R.H. Moore, ed. Report USUR-05, HEHF-47 Richland, WA: U. S. Uranium Registry and Joint Center for Graduate Study. Dygert, H.R., C.W. LaBelle, S. Laskin, U.C. Pozzani, E. Roberts, J.J. Rothermel, A. Rothstein, C.J. Spiegel, G.F. Sprague, Jr., and H.E. Stokinger. 1949. Toxicity following inhalation. Pp. 423-700 in Pharmacology and Toxicology of Uranium Compounds, C. Voegtlin, and H.C. Hodge, eds. New York: McGraw-Hill.

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Review of the Toxicologic and Radiologic Risks to Military Personnel from Exposures to Depleted Uranium During and After Combat Eisenbud, M., and T.F. Gesell. 1997. Environmental Radioactivity, 4th Ed. San Diego: Academic Press. EPA (U.S. Environmental Protection Agency). 1991. Risk Assessment Guidance for Superfund Volume 1: Human Health Evaluation Manual Supplemental Guidance: Standard Default Exposure Factors. Interim Final. OSWER Directive 9285.6-03. PB91-921314. Office of Solid Waste and Emergency Response, U.S. Environmental Protection Agency, Washington, DC. March 25, 1991 [online]. Available: http://www.epa.gov/oswer/riskassessment/pdf/oswer_directive_9285_6-03.pdf [accessed July16, 2007]. EPA (U.S. Environmental Protection Agency). 1999. Cancer Risk Coefficients for Environmental Exposure to Radionuclides. EPA 402-R-99-001. Federal Guidance Technical Report No. 13. Office of Air and Radiation, U.S. Environmental Protection Agency [online]. Available: http://www.epa.gov/radiation/docs/federal/402-r-99-001.pdf [accessed July 13, 2007]. FAS (Federation of American Scientists). 2000. GAU-8 Avenger. Aircraft Equipment. Military Analysis Network [online]. Available: http://www.fas.org/man/dod-101/sys/ac/equip/gau-8.htm [accessed June 19, 2006]. Faure, G., and T.M. Mensing. 2005. Isotopes: Principles and Applications, 3rd Ed. Hoboken, NJ: Wiley. Fetter, S., and F.N. von Hippel. 1999. The hazard posed by depleted uranium munitions. Sci. Global Secur. 8(2):125-161. Filippova, L.G., A.P. Nifatov, and E.R. Liubchanskii. 1978. Late sequelae of administering enriched uranium to rats [in Russian]. Radiobiologiia 18(3):400-405. Firestone, R.B., and V.S. Shirley. 1996. Table of Isotopes, 8th Ed., Vol. 2. New York: John Wiley and Sons. Fisenne, I.M., and G.A. Welford. 1986. Natural U concentration in soft tissues and bone of New York City residents. Health Phys. 50(6):739-746. Fisher, D.R., M.J. Swint, and R.L. Kathren. 1990. Evaluation of Health Effects in Sequoyah Fuels Corporation Workers from Accidental Exposure to Uranium Hexafluoride. NUREG/CR-5566. PNL 7328. Washington DC: U.S. Nuclear Regulatory Commission. Fisher, D.R., R.L. Kathren, and M.J. Swint. 1991. Modified biokinetic model for uranium from analysis of acute exposure to UF6. Health Phys. 60(3):335-342. Gilchrist, R.L., P.W. Nickola, J.A. Glissmeyer, and J. Mishima. 1999. Characterization of Airborne Depleted Uranium From April 1978 Test Firing of the 105-mm, APFSDS-T, M735E1 Cartridge. Report PNL-2881. Richland, WA: Battelle Pacific Northwest National Laboratory. June 1999. Gilman, A.P., D.C. Villeneuve, V.E. Secours, A.P. Yagminas, B.L. Tracy, J.M. Quinn, V.E. Valli, R.J. Willes, and M.A. Moss.1998a. Uranyl nitrate: 28-day and 91-day toxicity studies in the Sprague-Dawley rat. Toxicol. Sci. 41(1):117-128. Gilman, A.P., D.C. Villeneuve, V.E. Secours, A.P. Yagminas, B.L. Tracy, J.M. Quinn, V.E. Valli, and M.A. Moss. 1998b Uranyl nitrate: 91-day toxicity studies in the New Zealand white rabbit. Toxicol. Sci. 41(1):129-137. Gilman, A.P., M.A. Moss, D.C. Villeneuve, V.E. Secours, A.P. Yagaminas, B.L. Tracy, J.M. Quinn, G. Long, and V.E. Valli. 1998c. Uranyl nitrate: 91-day exposure and recovery studies in the male New Zealand white rabbit. Toxicol. Sci. 41(1):138-151. Glissmeyer, J.A., and J. Mishima. 1979. Characterization of Airborne Uranium from Test Firings of XM774 Ammunition. Report PNL-2944. Richland, WA: Pacific North-

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