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Suggested Citation:"Acronyms." Institute of Medicine. 2008. Improving the Quality of Cancer Clinical Trials: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/12146.
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Page 107
Suggested Citation:"Acronyms." Institute of Medicine. 2008. Improving the Quality of Cancer Clinical Trials: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/12146.
×
Page 108

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Acronyms ACS American Cancer Society CLIA Clinical Laboratory Improvement Amendments CMS Centers for Medicare & Medicaid Services CT computed tomography CTEP Cancer Therapy Evaluation Program DCE dynamic contrast enhanced EGF epidermal growth factor ER estrogen receptor FDA Food and Drug Administration FDAMA Food and Drug Administration Modernization Act FDG [18F]-2-fluoro-2-deoxy-D-glucose FR Federal Register GCRC General Clinical Research Center HER-2 human epidermal growth factor receptor 2 IND investigational new drug 107

108 IMPROVING THE QUALITY OF CANCER CLINICAL TRIALS IRAT Image Response Assessment Team IRB Institutional Review Board LBNL Lawrence Berkeley National Laboratory MALDI matrix assisted laser desorption/ionization MedPAC Medicare Payment Advisory Commission MRI magnetic resonance imaging MSKCC Memorial Sloan-Kettering Cancer Center mTOR mammalian target of rapamycin NCCS National Coalition for Cancer Survivorship NCI National Cancer Institute NIH National Institutes of Health NSCLC non-small cell lung cancer PARP poly(ADP-ribose) polymerase PET positron emission tomography PhRMA Pharmaceutical Research and Manufacturers of America pre-IDE preinvestigation device exemption PSA prostate-specific antigen RECIST Response Evaluation Criteria in Solid Tumors SOP standard operating procedure SPA special protocol assessment SPECT single photon emission computed tomography SPORE Specialized Program of Research Excellence TBAC Tissue Banking Analysis Center TGen Translational Genomics Research Institute TNF tumor necrosis factor VEGF vascular endothelial growth factor

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Improving the Quality of Cancer Clinical Trials: Workshop Summary Get This Book
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Scientists and clinicians seek a new paradigm that could improve the efficiency, cost-effectiveness, and overall success rate of cancer clinical trials, while maintaining the highest standards of quality. To explore innovative paradigms for cancer clinical trials and other ways to improve their quality, the National Cancer Policy Forum held a workshop, Improving the Quality of Cancer Clinical Trials, in Washington, DC. The main goals of the workshop were to examine new approaches to clinical trial design and execution that would: (1) better inform decisions and plans of those responsible for developing new cancer therapies (2) more rapidly move new diagnostic tests and treatments toward regulatory approval and use in the clinic (3) be less costly than current trials The resulting workshop summary will serve as input to the deliberations of an Institute of Medicine committee that will develop consensus-based recommendations for moving the field of cancer clinical trials forward.

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