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Review of NASA’s
Human Research Program
Evidence Books
A Letter Report
Committee on NASA’s Research on Human Health Risks
Board on Health Sciences Policy
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THE NATIONAL ACADEMIES PRESS • 500 Fifth Street, N.W. • Washington, DC 20001
NOTICE: The project that is the subject of this report was approved by the
Governing Board of the National Research Council, whose members are drawn
from the councils of the National Academy of Sciences, the National Academy
of Engineering, and the Institute of Medicine. The members of the committee
responsible for the report were chosen for their special competences and with
regard for appropriate balance.
This study was requested by the National Aeronautics and Space Administration
and supported by Award No. NNH08CC26B, T.O. #2, between the National
Academy of Sciences and the National Aeronautics and Space Administration.
Any opinions, findings, conclusions, or recommendations expressed in this
publication are those of the author(s) and do not necessarily reflect the view of
the organizations or agencies that provided support for this project.
Additional copies of this report are available from the National Academies
Press, 500 Fifth Street, N.W., Lockbox 285, Washington, DC 20055; (800) 624-
6242 or (202) 334-3313 (in the Washington metropolitan area); Internet,
http://www.nap.edu.
For more information about the Institute of Medicine, visit the IOM home page
at: www.iom.edu.
Copyright 2008 by the National Academy of Sciences. All rights reserved.
Printed in the United States of America
Suggested Citation: IOM (Institute of Medicine). 2008. Review of NASA’s
human research program evidence books: A letter report. Washington, DC: The
National Academies Press.
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The National Academy of Sciences is a private, nonprofit, self-perpetuating
society of distinguished scholars engaged in scientific and engineering research,
dedicated to the furtherance of science and technology and to their use for the
general welfare. Upon the authority of the charter granted to it by the Congress
in 1863, the Academy has a mandate that requires it to advise the federal
government on scientific and technical matters. Dr. Ralph J. Cicerone is
president of the National Academy of Sciences.
The National Academy of Engineering was established in 1964, under the
charter of the National Academy of Sciences, as a parallel organization of
outstanding engineers. It is autonomous in its administration and in the selection
of its members, sharing with the National Academy of Sciences the
responsibility for advising the federal government. The National Academy of
Engineering also sponsors engineering programs aimed at meeting national
needs, encourages education and research, and recognizes the superior
achievements of engineers. Dr. Charles M. Vest is president of the National
Academy of Engineering.
The Institute of Medicine was established in 1970 by the National Academy of
Sciences to secure the services of eminent members of appropriate professions
in the examination of policy matters pertaining to the health of the public. The
Institute acts under the responsibility given to the National Academy of Sciences
by its congressional charter to be an adviser to the federal government and, upon
its own initiative, to identify issues of medical care, research, and education. Dr.
Harvey V. Fineberg is president of the Institute of Medicine.
The National Research Council was organized by the National Academy of
Sciences in 1916 to associate the broad community of science and technology
with the Academy’s purposes of furthering knowledge and advising the federal
government. Functioning in accordance with general policies determined by the
Academy, the Council has become the principal operating agency of both the
National Academy of Sciences and the National Academy of Engineering in
providing services to the government, the public, and the scientific and
engineering communities. The Council is administered jointly by both
Academies and the Institute of Medicine. Dr. Ralph J. Cicerone and Dr. Charles
M. Vest are chair and vice chair, respectively, of the National Research Council.
www.national-academies.org
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COMMITTEE ON NASA’S RESEARCH ON HUMAN
HEALTH RISKS
DANIEL R. MASYS (Chair), Vanderbilt University Medical Center,
Nashville, TN
CHRISTOPHER HART, Federal Aviation Administration,
Washington, DC
CHARLES E. LAND, National Cancer Institute, Rockville, MD
GLORIA LEON, University of Minnesota–Twin Cities, Minneapolis
THOMAS F. OLTMANNS, Washington University, St. Louis
SUZANNE OPARIL, University of Alabama at Birmingham,
ERIC S. ORWOLL, Oregon Health & Science University, Portland
JAMES A. PAWELCZYK, Pennsylvania State University, University
Park
CAROL SCOTT-CONNER, University of Iowa, Iowa City
MICHAEL SILVERSTEIN, University of Washington, Seattle
SCOTT TRAPPE, Ball State University, Muncie, IN
LAURENCE R. YOUNG, Massachusetts Institute of Technology,
Cambridge
Liaison, Committee on Aerospace Medicine and the Medicine of Extreme
Environments
DAVID E. LONGNECKER, Association of American Medical
Colleges, Washington, DC
IOM Staff
CATHARYN T. LIVERMAN, Study Director
BRUCE M. ALTEVOGT, Study Director
FRANKLIN T. BRANCH, Research Associate
JUDITH L. ESTEP, Program Associate
ANDREW M. POPE, Director, Board on Health Sciences Policy
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Independent Report Reviewers
This report has been reviewed in draft form by individuals chosen for
their diverse perspectives and technical expertise, in accordance with
procedures approved by the NRC’s Report Review Committee. The
purpose of this independent review is to provide candid and critical
comments that will assist the institution in making its published report as
sound as possible and to ensure that the report meets institutional
standards for objectivity, evidence, and responsiveness to the study
charge. The review comments and draft manuscript remain confidential
to protect the integrity of the deliberative process. We wish to thank the
following individuals for their review of this report:
Jay Buckey, Dartmouth-Hitchcock Medical Center
Louis Anthony (Tony) Cox, Jr., Cox Associates
James Lackner, Brandeis University
Walter Schimmerling, Consultant
Peter Suedfeld, University of British Columbia
Warren Zapol, Massachusetts General Hospital
Although the reviewers listed above have provided many constructive
comments and suggestions, they were not asked to endorse the
conclusions or recommendations nor did they see the final draft of
the report before its release. The review of this report was overseen by
John R. Ball, American Society for Clinical Pathology, appointed by the
Institute of Medicine, who was responsible for making certain that an
independent examination of this report was carried out in accordance
vii
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with institutional procedures and that all review comments were
carefully considered. Responsibility for the final content of this report
rests entirely with the authoring committee and the institution.
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