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Preventing Mental, Emotional, and Behavioral Disorders Among Young People: Progress and Possibilities
Appendix E
Tables of Risk Factors
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TABLE E-1 Risk Factors for Depression
Developmental Period
Context
Individual
Family
School and Peers
Neighborhood and Community
Preconception/prenatal
Genetic predisposition1,2,3,6
Infancy
Left frontal lobe hypoactivation1,2,5
Difficult temperament, such as negative affect, difficult to soothe, and lower activity1
Insecure attachment1
Early childhood
Dysregulated growth hormone process2,3
Left frontal lobe hypoactivation2,5
Temperament: inhibited, socially reticent and easily upset2,4
Subsyndromal symptoms and dysthymia4
Insecure attachment1
Hostile to peers, socially inhibited4
Poor grades/achievement1,3
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Middle childhood
Dysregulated growth hormone process2,3
Left frontal lobe hypoactivation2,5
Temperament: apathy2
Negative cognitions about self and negative explanatory and inferential style1,2,3
Anxiety2
Dysthymia4
Insecure attachment1
Disengagement, involuntary, and emotion-focused coping2
Poor social skills: impulsive, aggressive, passive, withdrawal, poor social problems solving2,3
Parental depression1,2,3
Poor parenting: rejection, lack of parental warmth, high hostility, harsh discipline, high maternal negative affect3
Child abuse/maltreatment1
Loss1
Marital conflict3,4,5
or divorce1
Aversive family environment3
Peer rejection2,3,5 and poor-quality peer relationships3
Stressful life events2,5
Self-generated stressors4,5
Poor grades/achievement1,3
Poverty4
Community stressful events such as interpersonal conflict, separation, and loss1,4,5
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Developmental Period
Context
Individual
Family
School and Peers
Neighborhood and Community
Adolescence
Female gender1,2,3,4,5
Early puberty4
Dysregulated growth hormone process2,3
Left frontal lobe hypoactivation2
Difficult temperament: inflexibility, low positive mood, withdrawal, poor concentration2
Negative cognitions such as low global self-worth, perceived incompetence, negative explanatory and inferential style5
Anxiety1,2
Subsyndromal depressive symptoms2 and dysthymia4
Insecure attachment1,5
Disengagement, involuntary, and emotion-focused coping2
Poor social skills: communication skills and problem-solving skills2
Extreme need for approval and social support4
Parental depression1,2,3
Parent-child conflict1,2,3
Poor parenting: parental rejection, lack of parental warmth, rejection, high hostility, harsh discipline,2,3 high maternal negative affect3
Child abuse/maltreatment1
Single parent family (for girls only)1
Divorce1
Marital conflict3,4,5
Family conflict3
Aversive family environment3
Peer rejection2,3,5 and poor-quality peer relationships3
Stressful events2,5
Self-generated stressors4,5
Poor grades/achievement1,3
Poverty and low SES
Community-level stressful events such as conflict, separation, and loss1,4,5
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Young Adulthood
Dysregulated growth hormone process2,3
Left frontal lobe hypoactivation2,5
Early onset depression and anxiety2
Negative cognitions
Need for extensive social support4
Parental depression1,2,3
Decrease in social support accompanying entering new social context4
1Cicchetti and Toth (1998).
2Garber (2006).
3Hammen and Rudolph (2003).
4Reinherz, Tanner, et al. (2006).
5Garber and Flynn (2001).
6Schulenberg and Zarrett (2006).
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TABLE E-2 Risk Factors for Schizophrenia
Developmental Period
Context
Individual
Family
School and Peers
Neighborhood
Preconception/prenatal
Genetic predisposition2,3,4,5
2nd generation immigrant1,3
Problems during pregnancy (diabetes and bleeding)3,4
Problems with fetal growth and development4,5
Maternal stress during pregnancy (such as spousal death)3,4
Maternal infection or flu exposure during pregnancy2,4,5
Hypoxia-related delivery complications2,3,4,5
Male gender3,5
Parental diagnosis of schizophrenia2,4,5
Urban setting1,3,4
Low SES1
Infancy
Head injury2
Urban setting1,3,4
Social adversity1
Early childhood
Head injury2
Motor, language, and cognitive impairments3,4
Family dysfunction1
Urban setting1,3,4
Social adversity1
Middle childhood
Head injury2
Self-reported psychotic symptoms4
Family dysfunction1
Urban setting1,3,4
Social adversity1
Adolescence
Head injury2
Cannabis use3,4
Family dysfunction1
Urban setting1,3,4
Social adversity1
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Young adulthood
Head injury2
Family dysfunction1
Social adversity1
1Cantor-Graae (2007).
2Walker, Kestler, et al. (2004).
3Cannon and Clarke (2005a).
4Cannon and Clarke (2005b).
5Faraone, Brown, et al. (2002).
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TABLE E-3 Risk Factors for Substance Abuse
Developmental Period
Context
Individual
Family
School and Peers
Neighborhood and Community
Preconception/prenatal
Genetic predisposition1,2,3
Prenatal alcohol exposure3
Infancy
Early childhood
Difficult temperament1,2,3
Cold and unresponsive mother behavior Parental modeling of drug/alcohol using1
Middle childhood
Poor impulse control1,2,3
Low harm avoidance1,2
Sensation seeking1,2
Lack of behavioral self-control/regulation2
Aggressiveness1,2,3
Anxiety2
Depression2,3
Hyperactivity
ADHD1,2,3
Antisocial behavior1,3
Early persistent problem behaviors1
Early substance use1,2
Permissive parenting1,3
Parent–child conflict1
Low parental warmth1
Parental hostility1,3
Harsh discipline1,3
Child abuse/maltreatment2
Parental/sibling modeling of drug using1,2
Parental favorable attitudes toward alcohol and/or drugs1,2,3
Inadequate supervision and monitoring1,2,3
Parental involvement
Low parental aspirations for child
Lack of or inconsistent discipline
School failure1,2
Low commitment to school1
Peer rejection1,2
Deviant peer group2,3
Peer attitudes toward drug2
Interpersonal alienation1,2,3
Laws and norms favorable toward use1,2
Accessibility/availability1,2
Extreme poverty fort hose children antisocial in childhood1,2
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Adolescence
Behavioral disengagement coping
Negative emotionality
Conduct disorder
Favorable attitudes toward drugs
Rebelliousness
Early substance use
Antisocial behavior
School failure1
Low commitment to school1
Not college bound
Aggression toward peers
Associating with drug-using peers
Norms (e.g., advertising) favorable toward alcohol use
Accessibility/availability
Young adulthood
Lack of commitment to conventional adult roles
Antisocial behavior
Leaving home
Attending college
Substance-using peers
1Hawkins, Catalano, and Miller (1992).
2Mayes and Suchman (2006).
3Sher, Grekin, and Williams (2005).
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TABLE E-4 Risk Factors for Anxiety
Developmental Period
Context
Individual
Family
School and Peers
Neighborhood and Community
Preconception/prenatal
Genetic predisposition3
Infancy
Insecure attachment3
Marital satisfaction1
Discrepant coparenting1
Parental modeling of anxiety1
Specific traumatic experiences1
Specific traumatic experiences3
Early childhood
Behavioral inhibition2,3
Marital conflict1
Negative events2,3
Specific traumatic experiences2
Negative events2,3
Lack of control experiences
Specific traumatic experiences2
Negative life events2,3
Lack of control experiences
Middle childhood
Behavioral inhibition2,3
Disgust sensitivity3
Cognitive development allows cognitive errors3
Parental anxiety2; parental overcontrol2,3
Rejection1,3
Anxious childrearing3
Parents model, prompt, and reinforce threat appraisals and avoidant behavior2
Marital conflict1; poor marital adjustment1
Negative events2,3
Specific traumatic experiences2
Negative events2,3
Lack of control experiences
Specific traumatic experiences2
Negative life events2,3
Lack of control experiences
Adolescence
Behavioral inhibition2,3
Disgust sensitivity3
Cognitive development allows cognitive errors3
Marital conflict1
Family conflict1
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Young adulthood
Childhood history of untreated anxiety disorders4
Childhood history of poor physical health5
Poor physical health6,9
Childhood history of sleep and eating problems7
Spousal conflict8
Single parenthood10
Negative life events10
1Bögels and Brechman-Toussaint (2006).
2Donovan and Spence (2000).
3Muris (2006).
4Bittner, Egger, et al. (2007).
5Clark, Rodgers, et al. (2007).
6Benton, Christopher, and Walter (2007).
7Ong, Wickramaratne, et al. (2006).
8Whisman (2007).
9Mehnert and Koch (2007).
10Fergusson, Boden, and Horwood (2007).
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