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Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2008 Symposium (2009)

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. "DRUG DELIVERY SYSTEMS, Introduction--William J. Grieco and Efrosini Kokkoli." Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2008 Symposium. Washington, DC: The National Academies Press, 2009.

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Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2008 Symposium

DRUG DELIVERY SYSTEMS

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Front Matter (R1-R12)
DRUG DELIVERY SYSTEMS, Introduction--William J. Grieco and Efrosini Kokkoli (1-4)
Recent Developments in Needle-Free Drug Delivery--Samir Mitragotri (5-16)
Targeted Polymeric Nanotherapeutics--Jeff Hrkach (17-24)
Polymer Technology for Gene Therapy--Daniel W. Pack (25-32)
Traceable Drug Delivery: Lighting the Way with Qdots--Xiaohu Gao (33-40)
EMERGING NANOELECTRONIC DEVICES, Introduction--Jia Chen and Victor Zhirnov (41-44)
The Quest for the Next Information-Processing Technology--Jeffrey J. Welser (45-52)
Molecular and Polymer Nanodevices--Nikolai Zhitenev (53-58)
Roll Printing of Crystalline Nanowires for Integrated Electronic and Sensor Arrays--Ali Javey, Zhiyong Fan, Johnny C. Ho, and Roie Yerushalmi (59-70)
The Role of DNA in Nanoarchitectonics--Mihrimah Ozkan and Cengiz S. Ozkan (71-82)
COGNITIVE ENGINEERING, Introduction (83-86)
Cognitive Engineering: It's Not What You Think--Stephanie Guerlain (87-92)
Driving Attention: Cognitive Engineering in Designing Attractions and Distractions--John D. Lee (93-102)
Human Reliability Analysis in Cognitive Engineering and System Design--Ronald Laurids Boring (103-110)
Cognitive Engineering Applications in Health Care--Ann M. Bisantz (111-122)
UNDERSTANDING AND COUNTERING THE PROLIFERATION OF WEAPONS OF MASS DESTRUCTION, Introduction--J. Scott Goldstein and Gregory A. Hebner (123-126)
U.S. National Security in New Times--Steven D. Nixon (127-132)
Combating Weapons of Mass Destruction: Translating Strategic Guidance into Actionable Solutions--Charles L. Beames (133-140)
Nuclear Deterrence in the 21st Century: The Role of Science and Engineering--Joseph C. Martz and Jonathan S. Ventura (141-146)
Energy Policy and the Role of Technology in National Security--A.D. Romig, Jr. with Arnold B. Baker (147-158)
Contributors (159-168)
Program (169-172)
Participants (173-182)

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Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2008 Symposium DRUG DELIVERY SYSTEMS

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Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2008 Symposium Introduction WILLIAM J. GRIECO PetroAlgae Melbourne, Florida EFROSINI KOKKOLI University of Minnesota Minneapolis, Minnesota Historically, the concept of “drug delivery” has referred to any method of introducing a therapeutic agent into the human body. Traditional delivery methods included oral ingestion, injection, inhalation, and other pathways. Over the past 20 years, advances in materials, particularly polymer systems, have enabled more careful engineering of delivery systems. Current drug-delivery systems now include methods of using traditional mechanisms, such as oral and injection techniques, to introduce engineered particles or devices into the body that can eliminate the necessity of daily doses by providing sustained release therapies. Micro- and nanoengineered systems now offer opportunities to minimize systemic side effects by targeting the delivery of therapies to particular physiological systems. The presentations in this section provide an overview of drug-delivery methodologies from academic and industrial perspectives. The focus is on polymeric materials for engineering delivery systems. Speakers highlight several key technologies for targeting and controlling the release of bioactive materials.

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