Appendix D
Venture-funded Firms: Data from Hoover’s Small Business Database and VentureSource

Company

Venture Capital (Thousands of Dollars)

Rounds

Last Round Date

Advanced Tissue Sciences, Inc.

90,578.0

3

11/2/2001

Albion Instruments

8,968.0

7

1/1/1990

Ambion, Inc.

10,500.0

1

5/1/2003

Applied Immune Sciences, Inc.

44,060.1

11

1/1/1991

Applied Molecular Evolution, Inc.

32,350.0

6

6/1/2000

Aronex Pharmaceuticals, Inc.

9,496.0

3

3/2/1999

Aviron (FKA: Vector Pharmaceuticals, Inc.)

87,340.1

4

11/1/2000

Argus Software, Inc.

3,815.9

4

7/30/1999

Aurora Biosciences Corporation

18,720.0

3

12/15/1996

AcryMed, Inc.

3,500.0

4

3/1/2003

Alexion Pharmaceuticals, Inc.

5,800.0

2

12/23/1994

Automatix, Inc.

21,850.0

7

12/1/1987

Aastrom Biosciences, Inc.

36,384.9

8

10/30/2002

ABIOMED, Inc.

35,800.0

1

3/27/2007

Adolor Corporation

137,483.0

7

5/31/2001

Alkermes, Inc.

12,384.3

5

10/1/1992

Amylin Pharmaceuticals, Inc.

84,200.0

9

9/20/2002

ARIAD Pharmaceuticals, Inc.

56,075.0

3

5/20/2003

Aradigm Corporation

139,454.0

9

3/7/2003

Altea Therapeutics

54,546.9

4

6/15/2007

Amedica Corporation

44,569.0

4

4/27/2007

Amnis Corporation

18,750.0

3

3/27/2006

Ancile Pharmaceuticals, Inc.

30,365.0

6

10/27/2002



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Appendix D Venture-funded Firms: Data from Hoover’s Small Business Database and VentureSource Venture Capital Last (Thousands Round Company of Dollars) Rounds Date Advanced Tissue Sciences, Inc. 90,578.0 3 11/2/2001 Albion Instruments 8,968.0 7 1/1/1990 Ambion, Inc. 10,500.0 1 5/1/2003 Applied Immune Sciences, Inc. 44,060.1 11 1/1/1991 Applied Molecular Evolution, Inc. 32,350.0 6 6/1/2000 Aronex Pharmaceuticals, Inc. 9,496.0 3 3/2/1999 Aviron (FKA: Vector Pharmaceuticals, Inc.) 87,340.1 4 11/1/2000 Argus Software, Inc. 3,815.9 4 7/30/1999 Aurora Biosciences Corporation 18,720.0 3 12/15/1996 AcryMed, Inc. 3,500.0 4 3/1/2003 Alexion Pharmaceuticals, Inc. 5,800.0 2 12/23/1994 Automatix, Inc. 21,850.0 7 12/1/1987 Aastrom Biosciences, Inc. 36,384.9 8 10/30/2002 ABIOMED, Inc. 35,800.0 1 3/27/2007 Adolor Corporation 137,483.0 7 5/31/2001 Alkermes, Inc. 12,384.3 5 10/1/1992 Amylin Pharmaceuticals, Inc. 84,200.0 9 9/20/2002 ARIAD Pharmaceuticals, Inc. 56,075.0 3 5/20/2003 Aradigm Corporation 139,454.0 9 3/7/2003 Altea Therapeutics 54,546.9 4 6/15/2007 Amedica Corporation 44,569.0 4 4/27/2007 Amnis Corporation 18,750.0 3 3/27/2006 Ancile Pharmaceuticals, Inc. 30,365.0 6 10/27/2002 2

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3 APPENDIX D Annual First Last Revenue Round Ticker Known (Millions Number of Profit/ Date Status Symbol Date of Dollars) Employees Loss 4/1/1996 Out of business 2003 6/1/1986 Sold 2000 5/1/2003 Sold 2006 13.6 11/1/1984 Sold 1995 3/1/1990 Sold 10.2 7/1/1991 Sold 2001 6/1/1992 Sold 1/1/1995 Foreign 3/7/1996 Foreign 4/1/1994 n/a 11/12/1993 NASDAQ ALXN 1.6 241 (131.5) 1/1/1980 n/a 8/18/1989 NASDAQ ASTM 0.7 (17.6) 3/27/2007 NASDAQ AMMD 50.7 324 11/1/1994 NASDAQ ADLR 15.9 179 (69.7) 10/1/1987 NASDAQ alks 240.0 830 9.9 11/1/1987 NASDAQ AMLN 510.9 1,550 (218.9) 2/1/1991 NASDAQ ARIA 0.9 108 (61.9) 10/16/1992 OTC ARDM 4.8 103 (13.0) 11/21/2002 private 1/28/2004 private failed IPO 2007 0.1 33 (6.3) 2/28/2000 private 3.5 37 11/4/1998 private 3.2 30 continued

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 APPENDIX D Venture Capital Last (Thousands Round Company of Dollars) Rounds Date Artecel Sciences, Inc. 4,135.2 2 5/29/2002 Atherotech, Inc. 21,399.9 4 1/31/2005 Avocet Medical, Inc. 36,801.0 3 7/1/2001 BioCryst Pharmaceuticals, Inc. 39,964.9 3 9/30/2007 BioMarin Pharmaceutical, Inc. 53,000.0 2 5/16/2001 BIOQUAL, Inc. (FKA: Diagnon Corporation) 1,351.0 2 5/1/1983 Biosearch, Inc. 1,800.0 2 12/1/1983 Biosym Technologies, Inc. 5,168.0 3 4/1/1992 BioTransplant, Inc. 9,561.0 3 6/30/2001 Cambridge Neuroscience, Inc. (FKA: Synax, Inc.) 35,879.0 9 6/21/1997 Cell Based Delivery, Inc. 11,175.0 2 5/7/2002 Centaur Pharmaceuticals, Inc. 63,451.0 7 11/2/2001 Cephalon, Inc. 40,037.8 8 2/25/1999 Chektec Corporation 846.0 3 4/1/1993 Clarus Medical LLC (Medilase, Inc.) 27,548.9 12 5/1/1997 Clontech Laboratories, Inc. 28,836.0 2 7/1/1998 CoCensys, Inc. 24,071.0 9 1/7/1997 Cognetix, Inc. 19,010.0 2 6/1/2006 CompuCyte Corporation 18,700.0 3 8/1/1999 Conductus, Inc. 45,699.9 6 3/27/2002 Control Delivery Systems, Inc. (AKA: CDS, Inc.) 34,500.0 1 8/22/2000 COR Therapeutics, Inc. 20,652.0 6 1/1/1998 Corixa Corporation 157,581.1 6 6/10/2003 Cortex Pharmaceuticals, Inc. 9,100.0 2 7/1/1989 Creative BioMolecules, Inc. 23,284.0 18 7/1/1995 Cryolife, Inc. 3,057.0 3 6/1/1988 Cryopharm Corporation 30,346.0 10 1/1/1994 Cubist Pharmaceuticals, Inc. 36,283.0 5 9/23/1998 CuraGen Corporation 26,790.0 2 9/1/1999 CytoLogix Corporation 46,850.0 5 5/29/2002 Cytomation, Inc. 14,293.0 2 6/8/2001 Cytyc Corporation (FKA: Generitech Corporation) 35,154.9 4 5/1/1995 Dharmacon Research, Inc. 5,700.0 1 8/23/2002 Digirad Corporation (FKA: Aurora Technologies) 75,320.0 9 4/24/2002 DiscoveRx Corporation, Ltd. 28,406.0 5 2/20/2007 Discovery Laboratories, Inc. 13,211.0 2 6/20/2003 Displaytech, Inc. 70,225.1 5 3/12/2006 Edenspace Systems Corporation 5,250.0 1 4/23/2007 EKOS Corporation 85,900.4 8 6/27/2007 Endocyte, Inc. 60,700.2 4 3/23/2007 Epicyte Pharmaceutical, Inc. 22,200.0 4 4/16/2001 EpiGenesis Pharmaceuticals, Inc. 35,956.2 4 3/7/2007 Epoch Biosciences (FKA:MicroProbe Corporation) 30,030.2 13 7/1/1993

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 APPENDIX D Annual First Last Revenue Round Ticker Known (Millions Number of Profit/ Date Status Symbol Date of Dollars) Employees Loss 11/29/2000 private 0.1 1 3/31/1999 private 10/1/1996 private 8/1/1992 NASDAQ 6.2 52 (43.6) 1/1/1998 NASDAQ 84.2 314 (28.5) 7/1/1981 private 19.4 150 4/1/1983 private 4.6 65 10/1/1986 Sold 10/1/1995 Out of business 2003 1/1/1986 Sold 3/7/2002 Out of business 12/1/1992 Out of business 2002 10/1/1987 NASDAQ CEPH 18,641.1 2,895 144.8 12/1/1988 Out of business 1/6/1989 private 0.2 3 7/1/1997 private 17.0 175 2/1/1989 Sold 8/1/2001 Out of business 4/1/1996 private 6.7 28 9/1/1987 Sold 8/22/2000 Sold 2005 17.2 26 3/16/1988 Sold 2002 12/2/1994 Sold 2005 5/1/1988 AMEX COR 1.2 26 (16.2) 5/1/1982 NASDAQ CRIS 16.7 68 (8.8) 1/1/1986 NYSE CRY 81.3 363 0.4 1/1/1988 private 2.5 25 9/1/1992 NASDAQ CBST 194.8 410 (0.4) 3/1/1997 NASDAQ CRGN 39.6 666 (59.8) 1/1/1997 private 5/1/1997 Sold 1/1/1987 Sold 2006 608.0 1,500 139.5 8/23/2002 private 10.1 120 5/30/1995 NASDAQ DRAD 71.9 601 (6.3) 2/1/1999 private 3.3 40 11/5/2002 NASDAQ 0.0 160 (46.3) 4/11/2000 IPO 2002 3.2 47 4/23/2007 private 0.7 10 10/1/1996 private 9.5 99 7/1/2001 private 3.3 40 7/1/1996 Sold 2004 10/1/1997 private 3/1/1986 Sold 2004 continued

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 APPENDIX D Venture Capital Last (Thousands Round Company of Dollars) Rounds Date EraGen Biosciences, Inc. (FKA: Sulfonics, Inc.) 32,647.0 3 3/15/2007 Exogene Corporation 7,115.1 5 7/1/1993 Fluorous Technologies, Inc. (AKA: FTI) 3,650.0 2 5/23/2003 Genaera Corporation (FKA: Magainin Pharmaceuticals) 18,106.0 5 10/1/1998 Genaissance Pharmaceuticals, Inc. 75,749.9 4 11/4/2004 Genelabs Technologies, Inc. 34,949.4 8 6/29/2006 GeneMedicine, Inc. 8,900.0 2 7/13/1994 Genetic Therapy, Inc. 13,989.0 8 7/1/1994 GenPharm International, Inc. 18,989.1 8 2/29/2000 Geron Corporation 42,074.8 5 1/1/1996 Gilead Sciences, Inc. 32,060.0 6 8/1/1992 Gliatech, Inc. 32,596.1 7 6/1/1995 Hauser Chemical Research, Inc. 1,893.0 3 12/7/1990 Hawaii Biotech, Inc. 16,500.0 5 12/26/2006 Houston Biotechnology, Inc. 3,240.0 2 5/1/1986 Hypres, Inc. 39,841.0 20 12/31/2002 Icagen, Inc. 96,700.7 7 2/1/2007 Illumigen Biosciences, Inc. 7,950.0 8 7/6/2007 Illumina, Inc. 36,567.0 2 11/1/1999 Immtech Pharmaceuticals, Inc. (FKA: Immtech International) 2,509.0 3 2/14/1994 ImmuLogic Pharmaceutical Corporation 29,844.0 5 2/22/1993 Immunicon Corporation 106,800.4 7 6/29/2005 ImmunoGen, Inc. 21,934.0 7 1/1/1989 Immusol, Inc. 23,500.0 2 9/24/2003 IntraTherapeutics, Inc. (FKA: Cardia Catheter Company) 32,224.2 8 3/31/2000 Invitrogen Corporation 15,000.0 1 6/20/1997 Iomai Corporation 80,570.0 9 10/25/2006 Irvine Sensors Corporation 2,650.0 3 6/10/2003 Isis Pharmaceuticals 17,490.0 6 8/11/1994 Isolab, Inc. 2,744.0 2 6/28/1990 ISTO Technologies, Inc. 25,725.0 5 8/3/2007 Kurzweil Applied Intelligence, Inc. 26,122.1 13 1/1/1993 Large Scale Biology Corp. (FKA: Biosource Genetics Corp) 11,675.1 6 3/1/1998 Laser Diagnostic Technology, Inc. 13,310.9 5 11/30/2001 Laserscope 24,045.4 8 9/1/1987 LeukoSite, Inc. 32,613.1 8 7/1/1998 LifeSpan BioSciences, Inc. 19,000.0 1 4/17/2001 Linguagen Corporation 20,212.0 4 5/23/2006 Lucent Medical Systems, Inc. 6,700.0 2 9/25/1998 Lynx Therapeutics, Inc. 72,200.4 5 9/25/2003 Markwell Medical Institute, Inc. 882.0 5 5/1/1987 MediChem Research Inc. 35,000.0 1 6/28/1999 Medinox, Inc. 21,199.8 2 1/8/2002

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7 APPENDIX D Annual First Last Revenue Round Ticker Known (Millions Number of Profit/ Date Status Symbol Date of Dollars) Employees Loss 10/6/2005 private 10/1/1988 Sold 1996 6/20/2000 private 2.0 15 3/1/1988 NASDAQ GENR 0.9 46 (21.2) 8/1/1998 Sold 2005 10/1/1984 NASDAQ GNLB 11.2 66 (8.7) 10/1/1992 private 14.9 110 8/1/1988 private 1.0 15 2/29/2000 Sold 7/10/1992 NASDAQ GERN 3.3 90 (31.4) 8/1/1987 NASDAQ GILD 3,026.1 2,525 (1,190.0) 7/1/1988 Sold 2000 4/1/1988 Out of business 6/7/2002 private 5.1 65 10/1/1985 Sold 7/1/1983 private 8.0 33 10/1/1995 NASDAQ ICGN 8.4 72 (24.8) 5/1/2000 private 1.5 10 11/30/1998 NASDAQ ILMN 184.5 277 40.0 12/21/1992 AMEX IMM 4.3 27 (11.3) 5/1/1987 Out of business 2002 7/1/1988 NASDAQ IMMC 8.7 107 (24.0) 6/1/1981 NASDAQ IMGN 38.2 192 (19.0) 6/1/2001 Sold 10/7/1991 Sold 2001 6/20/1997 NASDAQ 1,263.5 4,835 (191.0) 1/1/1998 NASDAQ IOMI 1.5 66 (31.8) 10/1/1997 NASDAQ IRSN 30.8 166 (8.5) 2/1/1989 NASDAQ ISIS 24.5 258 (45.9) 5/1/1987 Foreign 3/1/2000 private 1.6 24 5/1/1984 private 12/1/1987 private 0.8 20 1/1/1994 Foreign 3/1/1983 Sold 2006 9/1/1994 Sold 1999 4/17/2001 private 3.3 40 12/30/2003 private 7/1/1997 private 0.5 7 2/15/1994 Sold 2007 6/1/1981 Out of business 6/28/1999 private 6/15/1999 private continued

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 APPENDIX D Venture Capital Last (Thousands Round Company of Dollars) Rounds Date MediSpectra, Inc. 58,970.0 8 7/21/2006 Meridian Instruments, Inc. 3,557.0 4 10/1/1993 Message Pharmaceuticals, Inc. 11,142.5 8 4/14/2004 MIICRO, Inc. 6,840.0 4 9/26/2001 MIDI 2.0 8,250 5/3/2004 Moberg Medical, Inc. (AKA: Moberg Research, Inc.) 5,473.8 6 4/1/1997 Molecular Dynamics, Inc. 22,717.0 7 7/1/1994 Myogen, Inc. 191,452.8 6 10/13/2004 Nanosphere, Inc. 80,130.1 5 5/16/2006 NeoGenesis, Inc. 22,999.9 1 6/21/2001 Nereus Pharmaceuticals, Inc. 127,345.6 8 8/9/2007 NeuroControl Corporation 22,800.0 9 1/4/2001 Neurocrine Biosciences, Inc. 21,499.9 6 5/23/1996 Neuron Therapeutics, Inc. (FKA: ICTUS Pharmaceuticals) 28,717.0 4 12/7/2001 NimbleGen Systems, Inc. 73,250.5 8 1/2/2007 Nimbus Medical, Inc. 9,635.1 3 7/1/1986 Octagen Corporation 4,800.0 2 3/6/2000 Ontogen 24,945.0 5 10/13/2000 Onyx Pharmaceuticals, Inc. 70,200.2 6 5/9/2002 Organ Recovery Systems 13,999.8 1 7/29/2004 Orquest, Inc. 42,814.8 5 10/16/2001 Palatin Technologies 45,700.0 3 1/30/2004 Panacos Pharmaceuticals, Inc. 26,550.0 3 6/28/2007 Perlan Therapeutics, Inc. 5,227.0 3 12/27/2001 Pharmacopeia Drug Discovery, Inc. 8,472.0 1 8/11/2005 PharmaSonics, Inc. 22,700.0 4 6/30/2002 Pharmavene, Inc. 13,044.0 3 6/1/1996 PHT Corporation (AKA: Personal Health Technologies Corp.) 48,250.2 6 10/18/2004 Phylos, Inc. 25,100.0 1 11/30/2000 Physical Optics Corporation 3,337.0 4 8/1/1990 Physical Sciences, Inc. 492.0 2 7/1/1995 Premier Laser Systems, Inc 6,145.0 4 1/1/1997 Progenics Pharmaceuticals, Inc. 21,448.0 2 12/27/2005 Promega Corporation 5,250.0 4 5/27/1993 PRP, Inc. 384.0 2 1/1/1996 Proteome, Inc. 8,100.0 1 12/1/1999 Quantum Dot Corporation (AKA: Q Dot) 39,150.0 3 8/10/2005 Quantum Magnetics, Inc. 3,800.0 3 7/1/1997 Replidyne, Inc. 126,500.1 6 8/17/2005 Repligen Corporation 12,234.0 3 5/1/1985 RiboGene, Inc. (FKA: Transgene) 48,233.2 15 2/1/1997 Sangamo Biosciences 16,950.0 3 12/31/2001 Sangart, Inc. 50,353.0 2 4/4/2007

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9 APPENDIX D Annual First Last Revenue Round Ticker Known (Millions Number of Profit/ Date Status Symbol Date of Dollars) Employees Loss 6/1/1996 private 1.6 21 5/1/1983 Sold 1/1/1998 Out of business 2004 10/31/1997 private 1.6 20 5/19/2005 private 1.3 25 1/1/1992 private 9/1/1987 Sold 1998 10/5/1998 Sold 2006 1/25/2000 NASDAQ NSPH 1.1 50 113.0 1/9/2001 Sold 2005 7/29/1998 private 9.3 29 3/3/1994 private 9/25/1992 NASDAQ NBIX 39.2 588 (107.2) 10/1/1998 private 9/1/2000 Sold 3/1/1988 Sold 1996 4/1/1998 private 5/19/1992 Out of business 2003 4/24/1992 NASDAQ 0.3 125 (92.7) 1/20/2003 private 2.4 27 6/8/1994 Sold 2003 11/1/1996 AMEX PTN 14.4 85 (27.8) 11/4/2000 NASDAQ PANC 0.3 32 (38.1) 6/4/1999 private 1.2 14 8/11/2005 NASDAQ PCOP 16.9 150 (27.8) 2/1/1997 Out of business 4/1/1993 Sold 11/3/1999 private 8.4 80 11/30/2000 private 1.7 18 8/1/1987 private 30.0 150 5/9/1995 private 12.4 150 4/1/1994 Out of business 12/1/1995 NASDAQ PGNX 69.9 149 (21.6) 10/1/1982 private 175.0 850 4/1/1996 private 6.8 130 12/1/1999 private 1/1/1999 Sold 2005 10/15/1995 Out of business 2/21/2002 NASDAQ RDYN 16.0 85 (29.3) 11/1/1981 NASDAQ RGEN 14.1 45 (0.9) 1/1/1990 Sold 1999 6/1/1996 NASDAQ SGMO 7.9 62 (17.9) 10/31/2004 private 7.3 35 continued

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90 APPENDIX D Venture Capital Last (Thousands Round Company of Dollars) Rounds Date Scios Nova, Inc.(F.K.A Scios Inc)California Biotechnology) 5,425.0 1 6/1/1982 Secretech 800.0 2 10/1/1990 Selective Genetics, Inc. (FKA: Prizm Pharmaceuticals, Inc.) 56,867.0 14 12/1/2003 Sepracor, Inc. 16,892.0 8 2/22/1993 Signal Pharmaceuticals, Inc. 44,543.7 10 12/1/1999 Spire Corporation 3,750.0 3 1/1/1987 Stratagene Cloning Systems 1,873.0 2 12/31/1992 Structural Bioinformatics, Inc. 46,371.7 4 3/22/2000 Sunesis Pharmaceuticals, Inc. (FKA: Mosaic Pharmaceutical) 163,338.1 8 5/30/2007 Synaptic Pharmaceutical Corporation (FKA:Neurogenetic 89,772.2 7 9/5/2001 Corp) T Cell Sciences, Inc. 3,634.0 3 10/1/1989 Targeted Genetics Corporation 46,450.0 4 6/28/2007 TechniScan Medical Systems, Inc. 6,400.0 1 2/5/2007 Tegic Communications, Inc. (AKA:T9 Text Input) 15,000.0 2 5/4/1999 Telefactor Corporation 450.0 3 12/31/1998 Telios Pharmaceuticals, Inc. 30,530.0 7 1/1/1993 Third Wave Technologies, Inc. 78,064.2 5 7/26/2000 TraceDetect, Inc. 1,600.0 2 11/17/2003 TransMolecular, Inc. 42,364.3 4 2/20/2004 Trimeris, Inc. (FKA: SL-1 Pharmaceuticals, Inc.) 38,283.0 6 9/1/1999 United Biomedical, Inc. 9,000.0 1 7/1/1997 UroCor, Inc. (FKA: CytoDiagnostics, Inc.) 16,600.1 5 7/1/1995 VaxGen, Inc. 29,449.0 2 3/1/1997 Vertex Pharmaceuticals, Inc. 13,538.0 5 10/1/1996 VueSonix Sensors 4,600.0 3 7/30/2004 Xeotron Corporation 9,000.0 1 5/1/2001 Xeyex Corporation 3,267.0 2 6/30/1999 Zynaxis, Inc.(FKA: Zynaxis Cell Science/PKH Labs) 37,581.0 8 1/1/1995 Martek Biosciences Corporation 35,167.1 8 1/1/1986 Vestar, Inc. 34,509.1 15 7/1/1981 Vical, Inc. 17,850.0 7 6/1/1987 NOTE: Hoover’s data reflect current data available through Hoover’s Small Business Database as of September 2007. SOURCES: Data on VC investments are from VentureSource; data on current and historical firms status are from Hoover’s Small Business Database ().

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91 APPENDIX D Annual First Last Revenue Round Ticker Known (Millions Number of Profit/ Date Status Symbol Date of Dollars) Employees Loss 6/1/1982 Sold 9/1/1989 Out of business 6/12/1992 private 1/1/1984 NASDAQ SEPR 1,196.5 228 184.6 1/1/1993 private 48.5 134 11/1/1979 NASDAQ SPIR 20.1 118 (8.1) 4/1/1987 Sold 11/1/1996 Sold 2/17/1998 NASDAQ SNSS 13.7 138 1/1/1987 Sold 4/1/1985 Out of business 6/1/1992 NASDAQ TGEN 9.9 95 (34.0) 2/5/2007 private 1/22/1998 Sold 12/31/1997 Sold 2000 1/1/1986 Sold 6/30/1995 NASDAQ TWTI 28.0 154 (18.9) 3/15/2002 private 1.4 12 9/30/1997 private 1.2 18 2/12/1993 NASDAQ TRMS 37.0 90 7.4 7/1/1997 private 13.8 285 7/1/1987 Sold 4/10/1996 private 1/1/1989 NASDAQ TRTX 216.4 320 (206.9) 6/9/2000 private 5/1/2001 Sold 2004 1/1/1997 Out of business 6/1/1988 Out of business 2/1/2005 NASDAQ MATK 270.0 582 14.9 7/1/1993 Out of business 2000 3/10/1993 NASDAQ VICL 14.7 155 (23.1)