BOX 1-1

“Class B Animal Dealers—While the Committee recognizes that the use of animals in research, under certain circumstances, has been beneficial to the advancement of biomedical research, the Committee would like assurances that such research is conducted as humanely as possible. In the case of the use of dogs and cats used in research and obtained from Class B dealers, the Committee is concerned that such dealers have the potential to provide animals that have not been treated in accord with USDA regulations for use in federally supported research. The Committee asks the NIH to seek an independent review by a nationally recognized panel of experts of the use of Class B dogs and cats in federally supported research to determine how frequently such animals are used in NIH research and to propose recommendations outlining the parameters of such use, if determined to be necessary.”

of Labor, Health and Human Services, and Education, and Related Agencies Appropriation Bill (S. 1710) report requested a study on this issue.


Based on the Fiscal Year (FY) 2008 Senate and House Appropriations Committee Reports,1 with the Pet Safety and Protection Act of 2007 as an additional impetus, Congress charged the National Institutes of Health (NIH) to determine the humane and scientific issues associated with the use of random source dogs and cats in research. In turn, NIH asked the National Academies to assemble a committee of experts to prepare a report that addresses the topic as defined in its statement of task (Box 1-2). In August 2008 the National Academies’ Institute for Laboratory Animal Research (ILAR) formed the Committee on Scientific and Humane Issues in the Use of Random Source Dogs and Cats (see Appendix A for biographies).


The following terms and definitions are used throughout this report. Where appropriate, the source of the definition is provided. The USDA Animal and Plant Health Inspection Service (APHIS) Animal Welfare Regulations (AWR) 9 CFR Ch. 1 (January 2006 Edition) contain the following definitions:


House Appropriations Committee Report 110-231 and Senate Appropriations Committee Report 110-107 regarding FY 2008 appropriations to the Department of Health and Human Services

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