2

 

The Use of Dogs and Cats in Research: Public Perception and Evolution of Laws and Guidelines

 

31

   

 Public Perceptions of Dogs and Cats and of Their Use in Research,

 

32

   

 The Animal Protection Movement,

 

34

   

 Evolution of Animal Care Oversight within the Scientific Community,

 

35

   

 Effects of Animal Protection Activities on Class B Dealers and on Scientific Access to Random Source Dogs and Cats,

 

37

   

 History of U.S. Laws and Guidelines Regarding the Use of Dogs and Cats in Research,

 

37

   

 References,

 

43

3

 

Use of Random Source Dogs and Cats for Research

 

45

   

 The “3Rs” Principle,

 

47

   

 Desirability of Random Source Dogs and Cats for Research,

 

48

   

 Random Source Dogs: Anatomic and Physiologic Attributes,

 

49

   

 Random Source Cats: Anatomic and Physiologic Attributes,

 

55

   

 IACUC and Principal Investigator Considerations Regarding the Use of Random Source Animals for Research,

 

57

   

 Deleterious Infectious Disease Issues,

 

59

   

 Zoonotic Disease Hazards among Random Source Animals,

 

60

   

 Adverse Effects of Infectious Disease on Research,

 

61

   

 Animal Welfare Issues,

 

62

   

 References,

 

64

4

 

Class B Dealers and Animals

 

71

   

 Trends in the Number of Class B Dogs and Cats Used in Research,

 

72

   

 The Role of Class B Dealers in Providing Random Source Animals,

 

77

   

 Trends in the Number of Class B Dealers,

 

78

   

 Sources of Dogs and Cats for Class B Dealers,

 

78

   

 Cost of Animals from Class B Dealers,

 

81

   

 AWA Enforcement,

 

82

   

 Inconsistencies in Quality among Class B Dealers,

 

86

   

 Alternatives to Class B Animals,

 

86

   

 Unresolved Class B Compliance Issues,

 

90

   

 References,

 

91

5

 

Conclusions and Recommendations

 

93

 

 

APPENDIX: Committee Biographies

 

99



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