TABLE 5-3 Interpretation of Hepatitis C Virus Diagnostic Test Results

If HCV Test Result Is:

Interpretation

Action

Anti-HCV Screening Test (EIA or CIA)

Anti-HCV Supplemental Test: RIBA

Anti-HCV Supplemental Test: HCV RNA

HCV Status

Additional Testing or Evaluation Required

Positive

Not done

Not done

Not known

HCV RNA; RIBA if RNA negative

Positive

Not done

Negative

Probably not currently HCV infected; further testing requireda

Obtain RIBA; if RIBA positive, repeat RNA

Positive (high s/co ratio)

Not done

Not done

Antibody probably true positive; need to distinguish past from current infection

HCV RNA

Positive

Negative

Not done

False positive anti-HCV

None

Positive

Positive

Not done

Past or current HCV infection

HCV RNA; if RNA positive, evaluate for liver disease

Positive

Positive

Negative

Probable past HCV infection with recoverya

Repeat HCV RNA to rule out active infectiona



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