Positive

Positive or not done

Positive

Current acute or chronic HCV infection

Evaluate for chronic infection and liver disease

Positive

Indeterminate

Not done

Not known; possible false-positive anti-HCV or recovery from past HCV infection

Test for HCV RNA or repeat anti-HCV testing

Positive

Indeterminate

Positive

Current acute or chronic HCV infection

Evaluate for chronic infection and liver disease

Positive

Indeterminate

Negative

Probably not currently infected;a possible false-positive anti-HCV or recovery from past HCV infection

Repeat HCV RNA or repeat anti-HCV testing

aA single negative HCV-RNA result cannot determine infection status, inasmuch as a person might have intermittent viremia.

Abbreviations: anti-HCV, antibody to HCV; EIA, enzyme immunoassay; CIA, enhanced chemiluminescence immunoassay; RIBA, recombinant immunoblot assay; RNA, ribonucleic acid; s/co ratio, signal-to-cutoff ratio.

SOURCE: Adapted from Ghany et al., 2009. Diagnosis, management, and treatment of Hepatitis C: An update. Hepatology 49(4):1335-1374.

Copyright 2009. Reprinted with permission of John Wiley & Sons, Inc.; CDC, 2009e.



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