FIGURE 2-1 Natural progression of hepatitis B infection.
Abbreviations: HBeAg, hepatitis B e antigen; anti-HBe, antibody to hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; HCC, hepatocellular carcinoma.
aTransmission occurs in 90% of infants of HBsAg+/HBeAg+ mothers and 15% of infants of HBsAg+/anti-HBe+ mothers.
b30% of those infected from the age of 1–5 years and under 7% of those infected at the age of 6 years or older.
cAbout 50% of patients by 5 years and 70% of patients by 10 years will seroconvert to anti-HBe.
d15-25% risk of premature death from cirrhosis and HCC.