CDC Perinatal Hepatitis B Virus Infection Case Definition
Perinatal hepatitis B in the newborn may range from asymptomatic to fulminant hepatitis.
HBsAg positivity in any infant aged >1–24 months who was born in the United States or in US territories to an HBsAg-positive mother
Comment: Infants born to HBsAg-positive mothers should receive hepatitis B immune globulin (HBIG) and the first dose of hepatitis B vaccine within 12 hours of birth, followed by the second and third doses of vaccine at 1 and 6 months of age, respectively. Postvaccination testing for HBsAg and anti-HBs (antibody to HBsAg) is recommended from 3 to 6 months following completion of the vaccine series. If HBIG and the initial dose of vaccine are delayed for >1 month after birth, testing for HBsAg may determine if the infant is already infected.
Abbreviations: CDC, Centers for Disease Control and Prevention; HBsAg, hepatitis B surface antigen; anti-HBs, antibody to HBsAg; HBIG, hepatitis B immune globulin.
SOURCE: CDC, 2009a.