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Guide for the Care and use of Laboratory Animals: Eighth Edition APPENDIX D About the Authors Janet C. Garber (Chair), DVM, PhD, received her Doctor of Veterinary Medicine degree from Iowa State University and her PhD in pathophysiology from the University of Wisconsin. Her experiences have included infectious disease research at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), primate medicine and research, GLP device and materials evaluation, and transplantation immunology. Her current interests are in the areas of laboratory animal facility management, infectious diseases, occupational health and safety, and research program management. She most recently was Vice President, Safety Assessment, at Baxter Healthcare Corporation and is now a consultant with Garber Consulting, LLC in North Carolina. Dr. Garber is currently a member of the Council on Accreditation, AAALAC, International, and previously served as Chair of the Council. She served on the ILAR Committee to Revise the Guide for the Care and Use of Laboratory Animals and the Committee on Occupational Health and Safety in the Care and Use of Research Animals. R. Wayne Barbee, PhD, is Professor and Associate Director of Research at the Department of Emergency Medicine, School of Medicine, Senior VCURES (Virginia Commonwealth University Reanimation Engineering Science Center) Fellow and Chair of the IACUC at the Virginia Commonwealth University. Dr. Barbee holds a master’s degree and doctorate in physiology with three decades of research involving a wide variety of animals (bats, cats, crabs, dogs, rodents, and swine) in a number of experimental settings. His research has focused on circulatory shock and resuscitation, acute and chronic rodent surgery, and analysis of rodent hemodynamics. He has
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Guide for the Care and use of Laboratory Animals: Eighth Edition been associated with IACUCs at small, medium, and large institutions for over two decades and is familiar with the oversight of animal care and use programs. He has served on multiple study sections for both the NIH and DOD. Dr. Barbee also served as an Oxford, UK 2006 fellow (recipient, VCU Harris-Manchester Award) where he examined policies, training, and security issues related to animal care and use within the UK. Joseph T. Bielitzki, MS, DVM, is Research Manager, University of Central Florida. Dr. Bielitzki has worked with non-human primates in the laboratory environment for 20 years. Over this period he has worked with macaques (pig-tail, long-tail, Japanese, rhesus, stump-tail), baboons (yellow, green and hybrids) squirrel monkeys, capuchin monkeys, mangabeys, gibbons, chimpanzees, orangutans, bonobos, and gorillas. In the area of non-human primates his area of expertise is in enteric diseases, nursery rearing, and colony management. He has also worked with mice and rats in a variety of international facilities. He was instrumental in the writing and acceptance of the NASA Bioethical Principles for the Use of Animals in Research (NPD 8910.1). He speaks frequently on IACUC function and the importance of ethics in the use of animals. His background includes experience in academia, industry, and government in the roles of attending veterinarian, program manager, and researcher. Leigh Ann Clayton, DVM, is Director of Animal Health at the National Aquarium in Baltimore where she also chairs the Animal Welfare Committee. Dr. Leigh Clayton has worked in the zoo/aquarium field or the exotic pet medicine field exclusively since 2000. As she has worked with animals held in aquatics systems both in recirculating fresh and salt water, she is experienced in managing disease and accomplishing preventive health programs for fishes, amphibians, and reptiles as well as birds and mammals. She is a Diplomate of the American Board of Veterinary Practitioners (Avian). Dr. Clayton has routinely used her knowledge of nitrogen cycling and the basics of a variety of life support system designs to solve health issues in these captive settings and help ensure adequate animal health. She has served on the Executive Board of the Association of Reptilian and Amphibian Veterinarians, a role that allowed her to routinely liaise with leading researchers in the amphibian medicine field. John C. Donovan, DVM, is President of BioResources Inc. Dr. Donovan has over 30 years’ experience working as a veterinarian in biomedical research and is board certified by the American College of Laboratory Animal Medicine (ACLAM). After 7 years in the U.S. Army’s Medical Research and Development Command, he spent 10 years at the National Institutes of Health, becoming the Director of the National Cancer Institute’s Office
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Guide for the Care and use of Laboratory Animals: Eighth Edition of Laboratory Animal Science. He began his career in the pharmaceutical industry in 1994 as Senior Director of Worldwide Laboratory Animal Resources for Rhone Poulenc-Rorer Pharmaceuticals, leading to his position as Vice President of Laboratory Animal Science and Welfare for Aventis Pharmaceuticals in 1999. In 2001 he moved to Wyeth Pharmaceuticals where he was Vice President of BioResources until his retirement in 2007. During his career, Dr. Donovan served in numerous professional leadership positions including President of ACLAM and President of the Board of Directors of the Pennsylvania Society for Biomedical Research (PSBR). He also served on several boards including those of the National Association for Biomedical Research, ACLAM, PSBR, and the New Jersey Association for Biomedical Research. Dennis F. Kohn, DVM, PhD, is Professor Emeritus of Clinical Comparative Pathology at Columbia University. He received his DVM from Ohio State University and a doctorate in Medical Microbiology from West Virginia University. He is board certified by the American College of Laboratory Animal Medicine. He has directed laboratory animal resource/comparative medicine programs at West Virginia University Medical Center, University of Texas Medical School at Houston, and the Health Sciences Division, Columbia University. His research interests have dealt primarily with the pathogenicity of Mycoplasma pulmonis in the respiratory tract of laboratory rats, and the experimental pathology induced within the CNS and joints of rats inoculated with M. pulmonis. He is a past president of the American College of Laboratory Animal Medicine and the American Society of Laboratory Animal Practitioners, and as chair of a number of American Association of Laboratory Animal Science committees. He has served as a Council member of AAALAC-International, as a member of the 1986 American Veterinary Medical Association’s Panel on Euthanasia, and the 1996 Institute of Laboratory Animal Resources’ committee to revise the Guide. Neil S. Lipman, VMD, is Director of the Center of Comparative Medicine and Pathology serving the Memorial Sloan-Kettering Cancer Center (MSKCC) and the Weill Medical College of Cornell University and is Professor of Veterinary Medicine in Pathology and Laboratory Medicine at Weill Cornell as well as a Laboratory Member at the Sloan-Kettering Institute at MSKCC. Dr. Lipman is a Diplomate of the American College of Laboratory Animal Medicine with over 25 years’ experience in laboratory animal medicine and science. Dr. Lipman has expertise in vivarium design, engineering, and operations, having designed over 1.5 million gross square feet of vivarium space and overseen the operation of a number of major academic animal resource programs. His research interests are principally translational and include development and analysis of new technologies especially with
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Guide for the Care and use of Laboratory Animals: Eighth Edition respect to rodent housing systems and monoclonal antibody production, the characterization of various animal models, understanding the etiopathogenesis of endocrinologic disorders affecting laboratory animal species, and development and analysis of novel therapeutic strategies. Throughout his career, Dr. Lipman has been extensively involved in the postgraduate training of laboratory animal specialists. Paul Locke, MPH, JD, DrPH, an environmental health scientist and attorney, is Associate Professor at the Johns Hopkins University Bloomberg School of Public Health in the Department of Environmental Health Sciences, Division of Toxicology. He holds an MPH from Yale University School of Medicine, a DrPH from the Johns Hopkins University Bloomberg School of Public Health and a JD degree from Vanderbilt University School of Law. Prior to joining the Department of Environmental Health, he was the Deputy Director of the Pew Environmental Health Commission and the Director of the Center for Public Health and Law at the Environmental Law Institute. Dr. Locke’s research and practice focus on how decision makers use environmental health science and toxicology in regulation and policy making and how environmental health sciences influence the policy-making process. His areas of study include alternatives to animal testing in biomedical research, with particular emphasis on toxicity testing. He also maintains an active research program in radiation studies and radiation protection policy. Dr. Locke directs the Doctor of Public Health degree program in the Department of Environmental Health Sciences and is co-director of the Johns Hopkins certificate program in Humane Science and Toxicology. From 2004 until 2009 he was a member of the National Academy of Sciences Nuclear and Radiation Studies Board, and has served on five National Academy of Sciences/National Research Council expert committees. He is admitted to practice law before the bars of the states of New York and New Jersey, the District of Columbia, the United States Court of Appeals for the Second Circuit and the United States Supreme Court. The Honorable John Melcher, DVM, a graduate of the College of Veterinary Medicine of the Iowa State University, was a practicing veterinarian in the state of Montana until 1969, in which year he was elected to the U.S. House of Representatives. He served as a Congressman for 8 years and as a Senator for 12 years. In both the House and the Senate, Senator Melcher was noted for his interest in agriculture, protection of public lands, notably Forest Service and Bureau of Land Management lands, and animal welfare and animal health protections. In 1984 he contributed to the Animal Welfare Act with an amendment requiring consideration of the psychological well being of primates used in medical research. After retiring from Congress, Senator Melcher established a second career as a consultant for the
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Guide for the Care and use of Laboratory Animals: Eighth Edition American Veterinary Medical Association and the American Association of Veterinary Medical Colleges. Senator Melcher represents the public’s perspective. Fred W. Quimby, VMD, PhD, is a board-certified laboratory animal veterinarian, with a doctorate in pathology, specialized in the assessment of immune function in animals. Prior to his retirement in 2007 he was Associate Vice President at Rockefeller University, while over the past 35 years he oversaw the research animal programs at three Universities (Tufts, Cornell, and Rockefeller) and held the position of Professor at Cornell’s Colleges of Medicine and Veterinary Medicine. He conducted research and lectured in the fields of immunology, pathology and environmental toxicology where he focused his research on toxic shock syndrome, environmental intoxication with polychlorinated biphenyls (PCBs), and immune dysfunction in pet dogs. As a laboratory animal professional he has designed and overseen the construction of five animal facilities for research animals and a zoological park. Dr. Quimby has had broad experience with a wide assortment of laboratory animals including rodents, dogs, primates, livestock, poultry, and fish, and published on the diseases, care, and /or housing of each of them. He has served on various NAS/NRC committees including the Guide committee, the Committee on Immunologically Compromised Rodents (Chair), the Transgenic Animal Committee, the Committee to Develop Standards for Dogs (Chair), the Monoclonal Antibody Production Committee, and the Committee Evaluating Increasing Veterinary Involvement in Biomedical Research. He served as a member of the ILAR Council and chaired the Editorial Committee of the ILAR News. He is currently serving as a member of the Committee to Assess the Current and Future Workforce Needs in Veterinary Medicine. He was a charter member of the Society for Veterinary Ethics, a member of the Board of Directors for the National Association for Biomedical Research and a member of the Strategic Planning Committee for AAALAC International. Patricia V. Turner, MS, DVM, DVSc, is Associate Professor and Program Leader of Laboratory Animal Science in the Department of Pathobiology at the University of Guelph, Canada, where she also is currently Chair of the Animal Care Committee. She has a doctorate in comparative pathology and is a Diplomate of both the American College of Laboratory Animal Medicine and the American Board of Toxicology. Dr. Turner has experience managing Canadian Council of Animal Care–compliant animal facilities that house a full range of species (fish, rodents and rabbits, dogs and cats, swine and sheep, nonhuman primates) in both academic and industry (GLP) settings. Dr. Turner serves as an AAALAC international ad hoc specialist with excellent knowledge of current US guidelines and
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Guide for the Care and use of Laboratory Animals: Eighth Edition regulations concerning research animal care and use. Her research interests include innate immunity and infectious disease, toxicologic pathology, and the interactions between rodents and their environment as they relate to disease susceptibility. In 2007 she was the inaugural recipient of the North American Animal Welfare Award, co-sponsored by Procter & Gamble and the Humane Society of the United States. Geoffrey A. Wood, DVM, PhD, DVSc, is Associate Professor in the Department of Pathobiology at the Ontario Veterinary College, University of Guelph, Canada. Dr. Wood has a doctorate in cancer biology and a doctorate in veterinary pathology. He has been involved in design or pathologic characterization of hundreds of genetically engineered rodents, both as the former Associate Director of Pathology at the Centre for Modeling Human Disease in Toronto, and in his current position. His lab conducts research on cancer genetics and the process of metastasis, with a focus on bone and prostate cancer. Dr. Wood’s research collaborations include projects investigating various aspects of a wide range of different cancer types, as well as studies on stem cell biology, immunity, and inflammation. Hanno Würbel, Dr.sc.nat, is Professor of Animal Welfare and Ethology at the Justus Liebig University in Giessen, Germany. He has studied biology (zoology) at the University of Berne, Switzerland and graduated from the ETH Zürich, Switzerland with a doctorate in natural sciences. He has experience in animal behavior and in the scientific assessment of animal well-being, and has mostly worked with rodents, but also with rabbits, dogs, poultry, and horses. His research focuses on environment-dependent plasticity of brain and behavior in relation to questions of animal husbandry and animal welfare. In 2005 Dr. Würbel received the Hessian Animal Welfare Research Prize and in 2009 the Felix Wankel Animal Welfare Research Award. He is a member of the Animal Welfare Council of the German government, Central Animal Welfare Officer of the University of Giessen, and head of the University’s Central Animal Facility. He is also a council member of the International Society of Applied Ethology (ISAE), editor of the Journal of Applied Animal Welfare Science, and editorial board member of the journal Applied Animal Behaviour Science.