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Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change - A Symposium Summary
Appendix C Symposium Agenda
TOXICITY-PATHWAY-BASED RISK ASSESSMENT:PREPARING FOR PARADIGM CHANGE
Public Meeting: May 11-13, 2009
National Academy of Sciences
2101 Constitution Avenue, NW
Washington, DC 20418
MONDAY, MAY 11, 2009
A PARADIGM CHANGE ON THE HORIZON
8:30
Welcome and Introduction
Warren Muir
Executive Director, Division on Earth and Life Studies
National Academies
8:35
Background on Standing Committee on Risk Analysis Issues and Reviews
Bernard Goldstein
Chair, Standing Committee on Risk Analysis Issues and Reviews
Professor, Department of Environmental and Occupational Health
University of Pittsburgh
8:40
EPA Expectations on Symposium
Peter Preuss
Director, National Center for Environmental Assessment
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Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change - A Symposium Summary
Appendix C
Symposium Agenda
TOXICITY-PATHWAY-BASED RISK ASSESSMENT: PREPARING FOR PARADIGM CHANGE
Public Meeting: May 11-13, 2009
National Academy of Sciences
2101 Constitution Avenue, NW
Washington, DC 20418
MONDAY, MAY 11, 2009
A PARADIGM CHANGE ON THE HORIZON
8:30
Welcome and Introduction
Warren Muir
Executive Director, Division on Earth and Life Studies
National Academies
8:35
Background on Standing Committee on Risk Analysis Issues and Reviews
Bernard Goldstein
Chair, Standing Committee on Risk Analysis Issues and Reviews
Professor, Department of Environmental and Occupational Health
University of Pittsburgh
8:40
EPA Expectations on Symposium
Peter Preuss
Director, National Center for Environmental Assessment
U.S. Environmental Protection Agency
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Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change - A Symposium Summary
8:45
Making Risk Assessment More Useful to Public and Private Decision-Makers in an Era of Paradigm Change
E. Donald Elliott
Member, Board on Environmental Studies and Toxicology
National Academies
Former EPA General Counsel
9:15
Emerging Science and Public Health
Lynn Goldman
Member, Symposium Planning Committee
Member, Standing Committee on Risk Analysis Issues and Reviews
Professor and Chair, Environmental Health Sciences
Johns Hopkins Bloomberg School of Public Health
9:45
Toxicity Testing in the 21st Century
Kim Boekelheide
Professor of Medical Sciences
Brown University
10:15
Symposium Roadmap
Lorenz Rhomberg
Chair, Symposium Planning Committee
Member, Standing Committee on Risk Analysis Issues and Reviews
Principal, Gradient Corporation
10:45
Break
THE NEW SCIENCE
Moderator: Lorenz Rhomberg, Chair, Symposium Planning Committee; Member, Standing Committee on Risk Analysis Issues and Reviews; Principal, Gradient Corporation
11:00
Overview of New Science
John Groopman
Anna M. Baetjer Professor of Environmental Health and Chair
Department of Environmental Health Sciences
Johns Hopkins Bloomberg School of Public Health
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Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change - A Symposium Summary
11:30
Gene-Environment Interactions
George Leikauf
Member, Symposium Planning Committee
Professor, University of Pittsburgh
12:00
Tools and Technologies for Pathway-Based Research
Ivan Rusyn
Associate Professor, Department of Environmental Science and Engineering
University of North Carolina at Chapel Hill
12:30
Lunch
PATHWAY-BASED APPROACHES FOR HAZARD ID
Moderator: Michael Lawton, Member, Symposium Planning Committee; Associate Research Fellow, Head, Molecular Toxicology Group, Pfizer, Inc.
1:30
ToxCast: Redefining Hazard Identification
Robert Kavlock
Director, National Center for Computational Toxicology
U.S. Environmental Protection Agency
2:00
Practical Applications: Pharmaceuticals
William Pennie
Executive Director, Compound Safety Prediction
Worldwide Medicinal Chemistry
Pfizer Global Research and Development
2:30
Practical Applications: Consumer Products
George Daston
Research Fellow
Procter & Gamble Company
3:00
Break
3:15
Practical Applications: Mixtures
John Groten
Vice President, Drug Safety Europe
Schering-Plough
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Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change - A Symposium Summary
3:45
Pathway-Based Approaches: A European/REACH Perspective
Thomas Hartung
Director, Center for Alternatives to Animal Testing
Johns Hopkins University
4:15
Panel Discussion
Panelists: Speakers and invited panelists (Charles Auer, former Director, Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency (retired); David Jacobson-Kram, Associate Director for Pharmacology and Toxicology, U.S. Food and Drug Administration)
5:00
Break
5:30
Poster Session
7:00
Adjourn
TUESDAY, MAY 12, 2009
APPLICATION TO MODE-OF-ACTION ANALYSIS
Moderator: Lauren Zeise, Member, Symposium Planning Committee; Chief, Reproductive and Cancer Hazard Assessment Section, California Environmental Protection Agency
8:30
What is Required for Acceptance
John Bucher
Associate Director, National Toxicology Program
National Institute of Environmental Health Sciences
9:00
Environmental Disease: Evaluation at the Molecular Level
Kenneth Ramos
Distinguished Professor, Department of Biochemistry and Molecular Biology
University of Louisville Health Science Center
9:30
Dioxin: Evaluation of Pathways at the Molecular Level
Alvaro Puga
Professor
University of Cincinnati
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Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change - A Symposium Summary
10:00
Systems Level Approaches for Understanding Principals of Nanomaterial Biocompatibility
Brian Thrall
Technical Group Leader, Cell Biology Group
Pacific Northwest National Laboratory
10:30
Break
11:00
Panel Discussion
Panelists: Speakers and invited panelists (William Kaufmann, Professor of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill; Jonathan Wiener, Perkins Professor of Law and Professor of Environmental Policy & Public Policy Studies, Duke University; Past President, Society for Risk Analysis)
12:00
Lunch
CHALLENGES AND OPPORTUNITIES FOR RISK ASSESSMENT IN THE CHANGING PARADIGM
Moderator: Joel Pounds, Member, Symposium Planning Committee; Senior Staff Scientist, Advisor to the Environmental Biomarkers Initiative, Pacific Northwest National Laboratory
1:00
Dose and Temporal Response
Elaine Faustman
Member, Symposium Planning Committee
Professor, Environmental and Occupational Health
University of Washington
1:30
Application of Genomic Dose-Response Data to Define Mode-of-Action and Low-Dose Behavior of Chemical Toxicants
Rusty Thomas
Director, Functional Genomics
The Hamner Institutes for Health Sciences
2:00
Using PBPK Models to Interpret Dose-Response of –Omics Data
Gregory L. Kedderis
Independent Researcher and Consultant
Chapel Hill, North Carolina
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Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change - A Symposium Summary
2:30
Modular Network Modeling of Toxicity Pathways for Extrapolation
Katrina Waters
Senior Research Scientist, Computational Biology & Bioinformatics
Pacific Northwest National Laboratory
3:00
Break
3:15
Integrating Global Gene Expression and Survival Across 60 Cell Lines: Applications for Risk Assessment
Albert J. Fornace, Jr.
Professor, Department of Biochemistry and Molecular and
Cellular Biology, Biomedical Graduate Research Organization;
Department of Oncology, Lombardi Comprehensive Cancer Center
Georgetown University
3:45
The FDA Experience in Analyzing Genomic Data
Federico Goodsaid
Associate Director for Operations in Genomics
U.S. Food and Drug Administration
4:15
Panel Discussion
5:30
Adjourn
WEDNESDAY, MAY 13, 2009
WHAT THE FUTURE HOLDS
Moderator: Lorenz Rhomberg, Chair, Symposium Planning Committee; Member, Standing Committee on Risk Analysis Issues and Reviews; Principal, Gradient Corporation
8:30
Are we “there” yet and Where is “there”?
The Path Forward (1, 5, and 10 years in the future)
A Perspective from EPA
Peter Preuss
Director, National Center for Environmental Assessment
U.S. Environmental Protection Agency
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Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change - A Symposium Summary
A Perspective from NIEHS
John Bucher
Associate Director, National Toxicology Program
National Institute of Environmental Health Sciences
A Perspective from the Chemical Industry
Tina Bahadori
Managing Director Long Range Research Initiative
American Chemistry Council
A Perspective from the Pharmaceutical Industry
Roger Ulrich
Chief Development Officer
Calistoga Pharmaceuticals, Inc.
A Perspective from Academia
Helmut Zarbl
Professor of Environmental and Occupational Medicine
University of Medicine and Dentistry of New Jersey
A Perspective from an Environmental Advocacy Group
Gina Solomon
Senior Scientist
Natural Resources Defense Council
10:30
Break
10:45
Panel Discussion
11:45
Symposium Close
Lorenz Rhomberg
Chair, Symposium Planning Committee
Member, Standing Committee on Risk Analysis Issues and Reviews
Principal, Gradient Corporation
12:00
Adjourn
