National Academies Press: OpenBook
« Previous: Appendix B: Biographic Information on the Planning Committee for a Symposium on Toxicity-Pathway-Based Risk Assessment
Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×

Appendix C
Symposium Agenda

TOXICITY-PATHWAY-BASED RISK ASSESSMENT: PREPARING FOR PARADIGM CHANGE


Public Meeting: May 11-13, 2009

National Academy of Sciences

2101 Constitution Avenue, NW

Washington, DC 20418


MONDAY, MAY 11, 2009

A PARADIGM CHANGE ON THE HORIZON

8:30

Welcome and Introduction

 

Warren Muir

Executive Director, Division on Earth and Life Studies

National Academies

8:35

Background on Standing Committee on Risk Analysis Issues and Reviews

 

Bernard Goldstein

Chair, Standing Committee on Risk Analysis Issues and Reviews

Professor, Department of Environmental and Occupational Health

University of Pittsburgh

8:40

EPA Expectations on Symposium

 

Peter Preuss

Director, National Center for Environmental Assessment

U.S. Environmental Protection Agency

Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×

8:45

Making Risk Assessment More Useful to Public and Private Decision-Makers in an Era of Paradigm Change

 

E. Donald Elliott

Member, Board on Environmental Studies and Toxicology

National Academies

Former EPA General Counsel

9:15

Emerging Science and Public Health

 

Lynn Goldman

Member, Symposium Planning Committee

Member, Standing Committee on Risk Analysis Issues and Reviews

Professor and Chair, Environmental Health Sciences

Johns Hopkins Bloomberg School of Public Health

9:45

Toxicity Testing in the 21st Century

 

Kim Boekelheide

Professor of Medical Sciences

Brown University

10:15

Symposium Roadmap

 

Lorenz Rhomberg

Chair, Symposium Planning Committee

Member, Standing Committee on Risk Analysis Issues and Reviews

Principal, Gradient Corporation

10:45

Break

THE NEW SCIENCE

Moderator: Lorenz Rhomberg, Chair, Symposium Planning Committee; Member, Standing Committee on Risk Analysis Issues and Reviews; Principal, Gradient Corporation

11:00

Overview of New Science

 

John Groopman

Anna M. Baetjer Professor of Environmental Health and Chair

Department of Environmental Health Sciences

Johns Hopkins Bloomberg School of Public Health

Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×

11:30

Gene-Environment Interactions

 

George Leikauf

Member, Symposium Planning Committee

Professor, University of Pittsburgh

12:00

Tools and Technologies for Pathway-Based Research

 

Ivan Rusyn

Associate Professor, Department of Environmental Science and Engineering

University of North Carolina at Chapel Hill

12:30

Lunch

PATHWAY-BASED APPROACHES FOR HAZARD ID

Moderator: Michael Lawton, Member, Symposium Planning Committee; Associate Research Fellow, Head, Molecular Toxicology Group, Pfizer, Inc.

1:30

ToxCast: Redefining Hazard Identification

 

Robert Kavlock

Director, National Center for Computational Toxicology

U.S. Environmental Protection Agency

2:00

Practical Applications: Pharmaceuticals

 

William Pennie

Executive Director, Compound Safety Prediction

Worldwide Medicinal Chemistry

Pfizer Global Research and Development

2:30

Practical Applications: Consumer Products

 

George Daston

Research Fellow

Procter & Gamble Company

3:00

Break

3:15

Practical Applications: Mixtures

 

John Groten

Vice President, Drug Safety Europe

Schering-Plough

Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×

3:45

Pathway-Based Approaches: A European/REACH Perspective

 

Thomas Hartung

Director, Center for Alternatives to Animal Testing

Johns Hopkins University

4:15

Panel Discussion

 

Panelists: Speakers and invited panelists (Charles Auer, former Director, Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency (retired); David Jacobson-Kram, Associate Director for Pharmacology and Toxicology, U.S. Food and Drug Administration)

5:00

Break

5:30

Poster Session

7:00

Adjourn

TUESDAY, MAY 12, 2009

APPLICATION TO MODE-OF-ACTION ANALYSIS

Moderator: Lauren Zeise, Member, Symposium Planning Committee; Chief, Reproductive and Cancer Hazard Assessment Section, California Environmental Protection Agency

8:30

What is Required for Acceptance

 

John Bucher

Associate Director, National Toxicology Program

National Institute of Environmental Health Sciences

9:00

Environmental Disease: Evaluation at the Molecular Level

 

Kenneth Ramos

Distinguished Professor, Department of Biochemistry and Molecular Biology

University of Louisville Health Science Center

9:30

Dioxin: Evaluation of Pathways at the Molecular Level

 

Alvaro Puga

Professor

University of Cincinnati

Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×

10:00

Systems Level Approaches for Understanding Principals of Nanomaterial Biocompatibility

 

Brian Thrall

Technical Group Leader, Cell Biology Group

Pacific Northwest National Laboratory

10:30

Break

11:00

Panel Discussion

 

Panelists: Speakers and invited panelists (William Kaufmann, Professor of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill; Jonathan Wiener, Perkins Professor of Law and Professor of Environmental Policy & Public Policy Studies, Duke University; Past President, Society for Risk Analysis)

12:00

Lunch

CHALLENGES AND OPPORTUNITIES FOR RISK ASSESSMENT IN THE CHANGING PARADIGM

Moderator: Joel Pounds, Member, Symposium Planning Committee; Senior Staff Scientist, Advisor to the Environmental Biomarkers Initiative, Pacific Northwest National Laboratory

1:00

Dose and Temporal Response

 

Elaine Faustman

Member, Symposium Planning Committee

Professor, Environmental and Occupational Health

University of Washington

1:30

Application of Genomic Dose-Response Data to Define Mode-of-Action and Low-Dose Behavior of Chemical Toxicants

 

Rusty Thomas

Director, Functional Genomics

The Hamner Institutes for Health Sciences

2:00

Using PBPK Models to Interpret Dose-Response of –Omics Data

 

Gregory L. Kedderis

Independent Researcher and Consultant

Chapel Hill, North Carolina

Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×

2:30

Modular Network Modeling of Toxicity Pathways for Extrapolation

 

Katrina Waters

Senior Research Scientist, Computational Biology & Bioinformatics

Pacific Northwest National Laboratory

3:00

Break

3:15

Integrating Global Gene Expression and Survival Across 60 Cell Lines: Applications for Risk Assessment

 

Albert J. Fornace, Jr.

Professor, Department of Biochemistry and Molecular and

Cellular Biology, Biomedical Graduate Research Organization;

Department of Oncology, Lombardi Comprehensive Cancer Center

Georgetown University

3:45

The FDA Experience in Analyzing Genomic Data

 

Federico Goodsaid

Associate Director for Operations in Genomics

U.S. Food and Drug Administration

4:15

Panel Discussion

5:30

Adjourn

WEDNESDAY, MAY 13, 2009

WHAT THE FUTURE HOLDS

Moderator: Lorenz Rhomberg, Chair, Symposium Planning Committee; Member, Standing Committee on Risk Analysis Issues and Reviews; Principal, Gradient Corporation

8:30

Are we “there” yet and Where is “there”?

The Path Forward (1, 5, and 10 years in the future)

 

A Perspective from EPA

Peter Preuss

Director, National Center for Environmental Assessment

U.S. Environmental Protection Agency

Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×

 

A Perspective from NIEHS

John Bucher

Associate Director, National Toxicology Program

National Institute of Environmental Health Sciences

 

A Perspective from the Chemical Industry

Tina Bahadori

Managing Director Long Range Research Initiative

American Chemistry Council

 

A Perspective from the Pharmaceutical Industry

Roger Ulrich

Chief Development Officer

Calistoga Pharmaceuticals, Inc.

 

A Perspective from Academia

Helmut Zarbl

Professor of Environmental and Occupational Medicine

University of Medicine and Dentistry of New Jersey

 

A Perspective from an Environmental Advocacy Group

Gina Solomon

Senior Scientist

Natural Resources Defense Council

10:30

Break

10:45

Panel Discussion

11:45

Symposium Close

 

Lorenz Rhomberg

Chair, Symposium Planning Committee

Member, Standing Committee on Risk Analysis Issues and Reviews

Principal, Gradient Corporation

12:00

Adjourn

Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×
Page 63
Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×
Page 64
Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×
Page 65
Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×
Page 66
Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×
Page 67
Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×
Page 68
Suggested Citation:"Appendix C: Symposium Agenda." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
×
Page 69
Next: Appendix D: Biographic Information on the Speakers and Panelists for a Symposium on Toxicity-Pathway-Based Risk Assessment »
Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary Get This Book
×
Buy Paperback | $46.00 Buy Ebook | $36.99
MyNAP members save 10% online.
Login or Register to save!
Download Free PDF

In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are being generated. As a result, the U.S. Environmental Protection Agency (EPA) expects a large influx of data that will need to be evaluated. EPA also is faced with tens of thousands of chemicals on which toxicity information is incomplete and emerging chemicals and substances that will need risk assessment and possible regulation. Therefore, the agency asked the National Research Council to convene a symposium to stimulate discussion on the application of the new approaches and data in risk assessment.

The symposium was held on May 11-13, 2009, in Washington, DC, and included presentations and discussion sessions on pathway-based approaches for hazard identification, applications of new approaches to mode-of-action analyses, the challenges to and opportunities for risk assessment in the changing paradigm, and future directions.

  1. ×

    Welcome to OpenBook!

    You're looking at OpenBook, NAP.edu's online reading room since 1999. Based on feedback from you, our users, we've made some improvements that make it easier than ever to read thousands of publications on our website.

    Do you want to take a quick tour of the OpenBook's features?

    No Thanks Take a Tour »
  2. ×

    Show this book's table of contents, where you can jump to any chapter by name.

    « Back Next »
  3. ×

    ...or use these buttons to go back to the previous chapter or skip to the next one.

    « Back Next »
  4. ×

    Jump up to the previous page or down to the next one. Also, you can type in a page number and press Enter to go directly to that page in the book.

    « Back Next »
  5. ×

    Switch between the Original Pages, where you can read the report as it appeared in print, and Text Pages for the web version, where you can highlight and search the text.

    « Back Next »
  6. ×

    To search the entire text of this book, type in your search term here and press Enter.

    « Back Next »
  7. ×

    Share a link to this book page on your preferred social network or via email.

    « Back Next »
  8. ×

    View our suggested citation for this chapter.

    « Back Next »
  9. ×

    Ready to take your reading offline? Click here to buy this book in print or download it as a free PDF, if available.

    « Back Next »
Stay Connected!