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Suggested Citation:"Appendix E: Symposium Presentations." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
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Appendix E
Symposium Presentations

All presentations are available on the CD on the inside of the back cover of this report.

Disclaimer: Some of the presentations on the CD differ slightly from the presentations given during the Symposium on Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change because those given during the symposium contained unpublished data that cannot be included in a published summary report. The presentations in question are by Elaine Faustman, Albert J. Fornace, Jr., Federico Goodsaid, and Ivan Rusyn.

Suggested Citation:"Appendix E: Symposium Presentations." National Research Council. 2010. Toxicity-Pathway-Based Risk Assessment: Preparing for Paradigm Change: A Symposium Summary. Washington, DC: The National Academies Press. doi: 10.17226/12913.
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In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are being generated. As a result, the U.S. Environmental Protection Agency (EPA) expects a large influx of data that will need to be evaluated. EPA also is faced with tens of thousands of chemicals on which toxicity information is incomplete and emerging chemicals and substances that will need risk assessment and possible regulation. Therefore, the agency asked the National Research Council to convene a symposium to stimulate discussion on the application of the new approaches and data in risk assessment.

The symposium was held on May 11-13, 2009, in Washington, DC, and included presentations and discussion sessions on pathway-based approaches for hazard identification, applications of new approaches to mode-of-action analyses, the challenges to and opportunities for risk assessment in the changing paradigm, and future directions.

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