2

Perturbation of cellular response pathway, leading to adverse effects,

8

3

DNA sequencing output,

11

4

Throughput potential for data acquisition as related to levels of biologic organization,

13

5

Illustration of bioactivity profiling using high-throughput technologies to screen chemicals,

14

6

Overview of chemical registration for REACH,

21

7

Integration of new approaches for toxicology,

22

8

Dosimetry considerations in cell systems,

28

9

What do cells see? Protein adsorption by nanomaterials is a universal phenomenon in biologic systems,

28

10

Example of gene ontology for DNA metabolism, a biologic process,

31

11

Framework for interpretation of dose- and time-dependent genomic data,

32

12

Integrated data provide more comprehensive and accurate network reconstruction,

36

13

Illustration of the development of modular network models,

37

14

Interaction network that can be used to associate environmental factors with toxicity pathways and associated human diseases,

43