Acronyms
α-CD20 |
anti-CD20, CD20 is cluster of differentiation 20, a cell surface protein |
α-CD33 |
anti-CD33, CD33 is cluster of differentiation 33 |
ADME |
absorption, distribution, metabolism, excretion |
Apo-A1 |
apolipoprotein A1 |
ASTM |
organization formerly known as the American Society for Testing and Materials |
βhCG |
β subunit of human chorionic gonadotropin |
BNP |
brain natriuretic peptide |
CAS |
Chinese Academy of Sciences |
CBEN |
Center for Biological and Environmental Nanotechnology |
CCNE |
Center of Cancer Nanotechnology Excellence |
CEN |
European Committee for Standardization |
CFU-GM |
colony-forming unit granulocyte macrophage |
CK-MB |
creatine kinase MB fraction (the MB fraction is most specific to cardiac muscle) |
CLIO-Cy5.5 |
cross-linked iron oxide Cy5.5 (Cy5.5 is a type of cyanine fluorescent dye) |
DARPA |
Defense Advanced Research Projects Agency |
DEAL |
DNA-encoded antibody barcode |
DFMO |
difluoromethylornithine |
DNA |
deoxyribonucleic acid |
DOX-OXD dextran conjugated doxorubicin | |
Doxorubicin-cBR96 |
doxorubicin conjugated to chimeric |
(α-CD174) |
monoclonal antibody cBR96 (anti-CD174, CD174 is cluster of differentiation 174, a cell surface protein) |
DTA-IL2 |
fusion fusion protein of diphtheria toxin fragment A |
protein (α-CD25) |
and interleukin 2 (this fusion protein targets CD25, a cell surface protein) |
EGCG |
epigallocatechin-3-gallate |
EGF |
epidermal growth factor |
EGFR |
epidermal growth factor receptor |
ELISA |
enzyme-linked immunosorbent assay |
EMEA |
European Medicines Agency |
EPA |
Environmental Protection Agency |
EUFETS |
a European contract manufacturer for cell and gene therapy |
FDA |
Food and Drug Administration |
Genexol-PM |
Genexol–polymeric micelle |
GFP |
green fluorescent protein |
GM-CSF |
granulocyte-macrophage colony stimulating factor |
GMP |
good manufacturing practices |
gp60 |
60 kDa glycoprotein, an albumin binding protein |
hCG |
human chorionic gonadotrophin |
HER2 |
human epidermal growth factor receptor 2 |
Hg |
mercury |
IBBC |
integrated blood barcode chip |
ICH |
International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use |
ICON |
International Council on Nanotechnology |
IFN-γ |
interferon-γ |
IL-1α |
interleukin-1α |
IL-1β |
interleukin-1β |
IL-2 |
interleukin-2 |
IL-6 |
interleukin-6 |
IL-10 |
interleukin-10 |
IL-12 |
interleukin-12 |
IND |
Investigational New Drug Application |
IOM |
Institute of Medicine |
ISO |
International Organization for Standardization |
IV |
intravenous |
KS |
Kaposi sarcoma |
LD50 |
median lethal dose |
LE-SN38 |
liposome-encapsulated 7-Ethyl-10-hydroxy-camptothecin |
LErafAON |
liposome encapsulated c-raf antisense oligonucleotide |
LMWP |
low molecular weight peptide |
MALDI TOF MS |
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry |
MCP-1 |
monocyte chemotactic protein-1 |
MFNP |
magneto/fluorescent nanoparticles |
MIT |
Massachusetts Institute of Technology |
MR |
magnetic resonance |
MRI |
magnetic resonance imaging |
MTX-HSA |
human serum albumin–bound methotrexate nab nanoparticle albumin-bound |
NCI |
National Cancer Institute |
NCL |
Nanotechnology Characterization Laboratory |
NIH |
National Institutes of Health |
NIST |
National Institute of Standards and Technology |
NK911 |
polymeric micelle carrier system for doxorubicin |
NMR |
nuclear magnetic resonance |
NNI |
National Nanotechnology Initiative |
NSAIDs |
non-steroidal anti-inflammatory drugs |
NSFC |
National Natural Science Foundation of China |
OECD |
Organisation for Economic Co-operation and Development |
Onco-TCS |
Onco-transmembrane carrier system, the drug vincristine |
OSHA |
Occupational Health and Safety Administration |
OSI-211 |
liposomal lurtotecan drug manufactured by |
OSI |
Pharmaceuticals |
P13K |
phosphatidylinositol 3-kinase |
PEG |
polyethylene glycol |
PEG-IFNα2a/-IFNα2b |
pegylated interferon α-2a/interferon α-2b |
PEG-L-asparaginase |
polyethylene glycol conjugated asparaginase |
PGA-paclitaxel |
polyglutamic acid conjugated paclitaxel |
PHPMA-doxorubicin |
poly(2-hydroxypropyl methacrylate) conjugated doxorubicin |
PK |
pharmacokinetics |
PK1 |
N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin |
PK2 |
N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer backbone and pendant doxorubicin (DOX) linked via a Gly-Phe-Leu-Gly peptide spacer |
PLD-E1A |
pegylated liposomal doxorubicin–linked E1A (an adenoviral oncogene) plasmid DNA |
PLGA |
polylactic-co-glycolic acid |
particle replication in non-wetting templates |
|
PSA |
prostate specific antigen |
RBC |
red blood cell |
RES |
reticuloendothelial system |
RNA |
ribonucleic acid |
RNAi |
RNA interference |
SGN-15 |
cBR96-doxorubicin immunoconjugate, SGN stands for Seattle Genetics Inc. |
siRNA |
short interfering RNA or silencing RNA |
SPARC |
secreted protein, acidic and rich in cysteine |
SPI-77 |
sterically stabilised liposomal cisplatin |
TGF-β |
transforming growth factor β |
TNF |
tumor necrosis factor |
TNF-γ |
tumor necrosis factor γ |
UK |
United Kingdom |
WBC |
white blood cell |