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Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2010 Symposium (2010)

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. "The Current Status and Future Outlook for Genomic Technologies--Mostafa Ronaghi and Jeffrey Fisher." Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2010 Symposium. Washington, DC: The National Academies Press, 2010.

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Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2010 Symposium

SUMMARY

Genomics has emerged as an important tool for studying biological systems. Significant cost reductions in genomic sequencing have accelerated the adaptation of this technology for applications in a variety of market segments (e.g., research, forensics, consumer products, agriculture, and diagnostics). The most important factor in reducing cost is increasing throughput per day. We predict that the cost of sequencing an entire genome will drop to a few hundred dollars in the next few years as throughput rises with increasing density, longer read length, and shorter cycle time.

In a year or so, the cost of genome sequencing will be less than the cost of single-gene testing, which by itself has already brought significant cost savings to health care. We also predict that genome sequencing will soon become a standard part of medical practice and that in the next 15 years everybody in the Western world will be genome-sequenced.

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Page
137
Front Matter (R1-R12)
CLOUD COMPUTING (1-2)
Introduction--Ali R. Butt and Dilma Da Silva (3-4)
Opportunities and Challenges of Cloud Computing--Armando Fox (5-14)
Warehouse-Scale Computing: The Machinery That Runs the Cloud--Luiz André Barroso (15-20)
Developing Robust Cloud Applications--Yuanyuan (YY) Zhou (21-26)
Green Clouds: The Next Frontier--Parthasarathy Ranganathan (27-38)
ENGINEERING AND MUSIC (39-40)
Introduction--Daniel Ellis and Youngmoo Kim (41-42)
Very Large Scale Music Understanding--Brian Whitman (43-46)
Doing It Wrong--Douglas Repetto (47-50)
Digital Instrument Building and the Laptop Orchestra--Daniel Trueman (51-60)
Demystifying Music and Its Performance--Elaine Chew (61-72)
AUTONOMOUS AEROSPACE SYSTEMS (73-74)
Introduction--Michel Ingham and Jack Langelaan (75-76)
Intelligent Autonomy in Robotic Systems--Mark Campbell (77-88)
Challenges and Opportunities for Autonomous Systems in Space--Chad R. Frost (89-102)
Health Awareness in Systems of Multiple Autonomous Aerospace Vehicles--Stefan Bieniawski (103-110)
Certifiable Autonomous Flight Management for Unmanned Aircraft Systems--Ella M. Atkins (111-124)
ENGINEERING INSPIRED BY BIOLOGY (125-126)
Introduction--Mark Byrne and Babak Parviz (127-128)
The Current Status and Future Outlook for Genomic Technologies--Mostafa Ronaghi and Jeffrey Fisher (129-138)
Engineering Biomimetic Peptides for Targeted Drug Delivery--Efrosini Kokkoli (139-148)
Autonomous Systems and Synthetic Biology--Henry Hess (149-158)
APPENDIXES (159-160)
Contributors (161-164)
Program (165-168)
Participants (169-178)