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Dietary Reference Intakes for Calcium and Vitamin D (2011)
Food and Nutrition Board (FNB)

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. "Appendix G: Cases Studies of Vitamin D Toxicity." Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press, 2011.

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DRI Dietary Reference Intakes Calcium Vitamin D

TABLE G-1 Case Studies of Vitamin D Toxicity

Study

Patient/Population

Preparation; Dose

Duration

Children

 

 

 

Djamil and Tu-Tunji. 1931. Lancet letter to the editor

2-yr-old male

Vigantol (irradiated ergosterol); 3 tsp

1 d

1947. BMJ letter to editor

Not specified

Cod liver oil

 

Ross. 1952. Journal of Pediatrics :815-822

4 infants ages 8-14 mo

Irradited ergosterol containing an estimated 30,000–40,000 IU vitamin

Daily for 8-12 mo

Jacqz et al. 1985

Infants with hypercalcemia (2 cases with vitamin D toxicity)

Vitamin D and calcium supplementation

 

 

Case 1: 3 mo old

 

 

 

Case 2: 7 mo old

300 μg D3

 

Besbas et al. 1989. Turkish J Pediatrics 31:239-244

Case 1: 3 mo old

Vitamin D: 45,000 IU/d

45 d

 

Case 2: 4 mo old

Vitamin D: 60,000 IU/d

30 d

Dent. 1964. BMJ letter to editor

6 yr old

Vitamin D (Calciferol Tablets B.P.): 1.25 mg. (~50,000 IU)/d

9 mo

Counts et al. 1975. Ann Internal Med 82:196-200

4-yr-old male

Vitamin D2 (Drisdol): 50,000 up to 100,000 IU/d

2 mo following bilateral nephrectomy

DeWind. 1960. Arch Dis Child 36:373-380

5.5 yr old

Vitamin D: 100,000 IU + cod liver oil-2 T + multivitamin

daily × 2–3 mo; and continued intake of tx vitamin D for 1 yr after hospitalization

Barrueto et al. 2005. Pediatrics 116:e453-e456

2-yr-old male

Vitamin D (ergocalciferol): 2,400,000 IU

4 d

Page
1026
Front Matter (R1-R16)
Summary (1-14)
1 Introduction (15-34)
2 Overview of Calcium (35-74)
3 Overview of Vitamin D (75-124)
4 Review of Potential Indicators of Adequacy and Selection of Indicators: Calcium and Vitamin D (125-344)
5 Dietary Reference Intakes for Adequacy: Calcium and Vitamin D (345-402)
6 Tolerable Upper Intake Levels: Calcium and Vitamin D (403-456)
7 Dietary Intake Assessment (457-478)
8 Implications and Special Concerns (479-512)
9 Information Gaps and Research Needs (513-522)
Appendix A: Acronyms, Abbreviations, and Glossary (523-536)
Appendix B: Issues and Interests Identified by Study Sponsors (537-538)
Appendix C: Methods and Results from the AHRQ-Ottawa Evidence-Based Report on Effectiveness and Safety of Vitamin D in Relation to Bone Health (539-724)
Appendix D: Methods and Results from the AHRQ-Tufts Evidence-Based Report on Vitamin D and Calcium (725-1012)
Appendix E: Literature Search Strategy (1013-1018)
Appendix F: Evidence Maps (1019-1024)
Appendix G: Cases Studies of Vitamin D Toxicity (1025-1034)
Appendix H: Estimated Intakes of Calcium and Vitamin D from National Surveys (1035-1044)
Appendix I: Proportion of the Population Above and Below 40 nmol/L Serum 25-Hydroxyvitamin D Concentrations and Cumulative Distribution of Serum 25-Hydroxyvitamin D Concentrations: United States and Canada (1045-1058)
Appendix J: Workshop Agenda and Open Session Agendas (1059-1064)
Appendix K: Biographical Sketches of Committee Members (1065-1074)
Index (1075-1102)
Summary Tables: Dietary Reference Intakes (1103-1116)