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J Workshop Agenda and Open Session Agendas IOM Committee to Review Dietary Reference Intakes for Vitamin D and Calcium March 26, 2009 Room 100 500 Fifth Street NW, Washington DC 2:00 pm–4:30 pm Open Session Agenda 2:00 pm Welcome Catharine Ross, Chairperson 2:05 pm Presentations from Study Sponsors: U.S. and Canadian Governments David Klurfeld, U.S. Department of Agriculture/Agricultural Research Service Danielle Brule, Health Canada Kathryn McMurry, U.S. Department of Health and Human Services 2:30 pm —Discussion with Committee Members— 2:50 pm Presentations on Survey Data Available to the Committee United States: Margaret McDowell, National Center for Health Statistics 1059

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1060 DIETARY REFERENCE INTAKES FOR CALCIUM AND VITAMIN D Canada: Mary L’Abbe, Health Canada 3:05 pm —Discussion with Committee Members— 3:20 pm Systematic Reviews in Nutrition/DRIs Joseph Lau, Tufts Medical Center 3:40 pm —Discussion with Committee Members— 3:45 pm Analysis of Vitamin D in Food Control Materials and Fortified Foods Wm. Craig Byrdwell, U.S. Department of Agriculture/Agricultural Research Service/Beltsville Human Nutrition Research Center 4:00 pm Analytical Issues for Detecting 25(OH)D in Serum Christine Pfeiffer and Rosemary Schleicher, Centers for Disease Control and Prevention 4:15 pm —Joint Discussion with Committee Members— 4:40 pm Adjourn Open Session Committee to Review Dietary Reference Intakes for Vitamin D and Calcium 500 Fifth Street NW, Washington DC, Room 100 August 4, 2009 8:00 am–5:00 pm INFORMATION-GATHERING WORKSHOP AGENDA 7:30 am Registration and Check-in 8:00 am Welcome and Overview of Committee Process & Open Session Catharine Ross, Chair SESSION 1: Agency for Healthcare Research and Quality (ARHQ) 8:10 am Development of AHRQ Review: Relationships of Vitamin D and Calcium Intakes to Nutrient Status Indicators and Health Outcomes (released June 2009) Joseph Lau, Tufts University

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1061 APPENDIX J 8:35 am Committee Discussion with Dr. Lau and Tufts University Staff SESSION 2: Analytical Issues: Vitamin D 9:15 am Comparison of Methods Karen Phinney, National Institute of Standards and Technology (NIST) 9:35 am Analytical Issues: National Health and Nutrition Examination Survey (NHANES) Clifford Johnson, National Center for Health Statistics (NCHS) 9:50 am Joint Discussion with Committee 10:15 am Break SESSION 3: Biomarkers 10:30 am Biomarkers: General Principles for Definition and Utility as Measures of Exposure or Functional Outcome Roberta Ness, University of Texas Health Science Center and IOM Committee on Biomarkers as Surrogate Endpoints of Chronic Disease Risk 10:50 am Committee Discussion with Dr. Ness SESSION 4: Vascular Changes 11:00 am Vascular Changes Associated with Vitamin D and Calcium Keith Hruska, Washington University, St. Louis 11:15 am Committee Discussion with Dr. Hruska SESSION 5: Chronic Disease Endpoints: Observational Data versus Randomized Clinical Trials 11:35 am Edward Giovannucci, Harvard University 11:50 am Barry Kramer, National Institutes of Health (NIH) 12:05 pm Joint Discussion with Committee 12:30 pm LUNCH

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1062 DIETARY REFERENCE INTAKES FOR CALCIUM AND VITAMIN D SESSION 6: Perspectives on Evaluating Data for Determining Reference Values for Vitamin D and Calcium Perspectives from 1995-96 DRI Committee 1:30 pm Stephanie Atkinson, McMaster University: Perinatal 1:40 pm Connie Weaver, Purdue University: Adolescents 1:50 pm Bess Dawson-Hughes, Tufts University: Elderly 2:00 pm Robert Heaney, Creighton University: Calcium and Calcium/ Vitamin D Interactions 2:10 pm Michael Holick, Boston University: Dietary vs. Solar Sources 2:20 pm Joint Discussion with Committee 2:45 pm Break Perspectives from Other Vitamin D and Calcium Experts 3:00 pm Bruce Hollis, Medical University of South Carolina: Assay Methodologies 3:10 pm Cedric Garland, University of California—San Diego: Cancer 3:20 pm Roger Bouillon, Katholieke Universiteit Leuven: Immune Function 3:30 pm Reinhold Vieth, University of Toronto: Safety of Vitamin D 3:40 pm Joint Discussion with Committee 4:00 pm Break SESSION 7: PUBLIC COMMENTS—5 minutes each (required pre-registration) GrassrootsHealth (Carole Baggerly) University of California—Riverside & Vitamin D Workshop (Tony Norman) University of California—San Diego (Edward Gorham) Sunlight, Nutrition, and Health Research Center (William Grant)

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1063 APPENDIX J St. Luke’s-Roosevelt Hospital Center (Linda Linday) Autoimmunity Research Foundation (Amy Proal) Weill Cornell Medical College (Paul Albert) The Mount Sinai Hospital and Mount Sinai School of Medicine (Laurie Tansman) International Diary Foods Association (Michelle Matto) National Osteoporosis Foundation (Roberta Biegel) National Dairy Council (Jill Nicholls) Lallemand/American Yeast (James Kopp, Sr.) 5:00 Workshop Adjourned Committee to Review Dietary Reference Intakes for Vitamin D and Calcium Informal Small-Group Data Gathering with Survey Representatives October 22, 2009 4:30 pm 500 Fifth Street NW, Washington DC Presentations and Discussions on U.S. and Canadian Survey Differences PARTICIPANTS United States Mr. Clifford Johnson, National Center for Health Statistics, DHANES Dr. Alanna Moshfegh, USDA Agricultural Research Service, Food Surveys Dr. Joanne Holden, USDA Agricultural Research Service, Nutrient Data Lab Canada (by telephone) Dr. Steve Brooks, Bureau of Nutritional Sciences, Health Canada Ms. Maya Villeneuve, Nutrition Research Division, Health Canada

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1064 DIETARY REFERENCE INTAKES FOR CALCIUM AND VITAMIN D Committee to Review Dietary Reference Intakes for Vitamin D and Calcium Fifth Meeting: November 19–20, 2009 The National Academy of Sciences Auditorium 2100 C Street, NW Washington, DC Open Session Agenda Thursday, November 19, 2009 Open Session—NAS Lecture Room 8:45 am Welcome to Open Session Catharine Ross, chair 9:00 am Open Session: Discussion of the Role of Vitamin D and Calcium in Kidney Function, Neophrocalcinosis, and Nephrolithiasis (Response to Targeted Questions) I. Epidemiology of Renal Toxicity: Vitamin D and Calcium Gary Curhan, Harvard Medical School, Brigham & Women’s Hospital II. Pathophysiology of Renal Toxicity in Children Craig Langman, Feinberg School of Medicine, Northwestern University, Chicago III. Pathophysiology of Renal Toxicity in Adults David Bushinsky, School of Medicine and Dentistry, University of Rochester 10:00 am Q&A with Committee Members 11:00 am Adjourn open session