Dietary Reference Intakes for Calcium and Vitamin D

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Table of Contents
Front Matter R1-R16
Summary 1-14
1 Introduction 15-34
2 Overview of Calcium 35-74
3 Overview of Vitamin D 75-124
4 Review of Potential Indicators of Adequacy and Selection of Indicators: Calcium and Vitamin D 125-344
5 Dietary Reference Intakes for Adequacy: Calcium and Vitamin D 345-402
6 Tolerable Upper Intake Levels: Calcium and Vitamin D 403-456
7 Dietary Intake Assessment 457-478
8 Implications and Special Concerns 479-512
9 Information Gaps and Research Needs 513-522
Appendix A: Acronyms, Abbreviations, and Glossary 523-536
Appendix B: Issues and Interests Identified by Study Sponsors 537-538
Appendix C: Methods and Results from the AHRQ-Ottawa Evidence-Based Report on Effectiveness and Safety of Vitamin D in Relation to Bone Health 539-724
Appendix D: Methods and Results from the AHRQ-Tufts Evidence-Based Report on Vitamin D and Calcium 725-1012
Appendix E: Literature Search Strategy 1013-1018
Appendix F: Evidence Maps 1019-1024
Appendix G: Cases Studies of Vitamin D Toxicity 1025-1034
Appendix H: Estimated Intakes of Calcium and Vitamin D from National Surveys 1035-1044
Appendix I: Proportion of the Population Above and Below 40 nmol/L Serum 25-Hydroxyvitamin D Concentrations and Cumulative Distribution of Serum 25-Hydroxyvitamin D Concentrations: United States and Canada 1045-1058
Appendix J: Workshop Agenda and Open Session Agendas 1059-1064
Appendix K: Biographical Sketches of Committee Members 1065-1074
Index 1075-1102
Summary Tables: Dietary Reference Intakes 1103-1116

Committee to Review Dietary Reference

Intakes for Vitamin D and Calcium

Fifth Meeting: November 19–20, 2009

The National Academy of Sciences

Auditorium

2100 C Street, NW

Washington, DC

Open Session Agenda

Thursday, November 19, 2009

Open Session—NAS Lecture Room

8:45 am	Welcome to Open Session Catharine Ross, chair
9:00 am	Open Session: Discussion of the Role of Vitamin D and Calcium in Kidney Function, Neophrocalcinosis, and Nephrolithiasis (Response to Targeted Questions)
I.	Epidemiology of Renal Toxicity: Vitamin D and Calcium Gary Curhan, Harvard Medical School, Brigham & Women’s Hospital
II.	Pathophysiology of Renal Toxicity in Children Craig Langman, Feinberg School of Medicine, Northwestern University, Chicago
III.	Pathophysiology of Renal Toxicity in Adults David Bushinsky, School of Medicine and Dentistry, University of Rochester
10:00 am	Q&A with Committee Members
11:00 am	Adjourn open session

Table of Contents

Front Matter R1-R16

Summary 1-14

1 Introduction 15-34

2 Overview of Calcium 35-74

3 Overview of Vitamin D 75-124

4 Review of Potential Indicators of Adequacy and Selection of Indicators: Calcium and Vitamin D 125-344

5 Dietary Reference Intakes for Adequacy: Calcium and Vitamin D 345-402

6 Tolerable Upper Intake Levels: Calcium and Vitamin D 403-456

7 Dietary Intake Assessment 457-478

8 Implications and Special Concerns 479-512

9 Information Gaps and Research Needs 513-522

Appendix A: Acronyms, Abbreviations, and Glossary 523-536

Appendix B: Issues and Interests Identified by Study Sponsors 537-538

Appendix C: Methods and Results from the AHRQ-Ottawa Evidence-Based Report on Effectiveness and Safety of Vitamin D in Relation to Bone Health 539-724

Appendix D: Methods and Results from the AHRQ-Tufts Evidence-Based Report on Vitamin D and Calcium 725-1012

Appendix E: Literature Search Strategy 1013-1018

Appendix F: Evidence Maps 1019-1024

Appendix G: Cases Studies of Vitamin D Toxicity 1025-1034

Appendix H: Estimated Intakes of Calcium and Vitamin D from National Surveys 1035-1044

Appendix I: Proportion of the Population Above and Below 40 nmol/L Serum 25-Hydroxyvitamin D Concentrations and Cumulative Distribution of Serum 25-Hydroxyvitamin D Concentrations: United States and Canada 1045-1058

Appendix J: Workshop Agenda and Open Session Agendas 1059-1064

Appendix K: Biographical Sketches of Committee Members 1065-1074

Index 1075-1102

Summary Tables: Dietary Reference Intakes 1103-1116