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TABLE 4-5 Serum 25OHD Levels and Bone Health Outcomes for Infants: Summary from AHRQ-Ottawa Analysesa

Reference;

Country;

Jadad Score for RCTsb

Population Description

Intervention/Duration

Bone Health Outcomes

Results

RCTs

Greer et al., 1982

Healthy full-term infants; exclusively breast-fed

IG1: 400 IU vit D2/d

CG: placebo

Distal L radius BMC (SPA)

Serum 25OHD, mean (nmol/L)

Baseline: no significant difference between groups

United States

 

 

 

 

 

12 wk:

IG1: 95* (graph)

CG: 50

n = 18

12 wk (double-blind)

 

Measured at 3, 6, 12, 26, 40, and 52 wks

Jadad = 3

66% female

 

 

At 6 mo, unblinded to mother, and placebo group began to receive 400 IU vit D2/d

17 Caucasian

1 Asian-Indian

26 wk:

IG1: 81.8

CG: 32.3

 

 

BMC, mean (SEM) (mg/cm)

12 wk: IG1 79 (3); CG 64 (3); p< 0.003

26 wk: IG1 70 (6); CG 75 (5); NS

52 wk: IG1 108 (20); CG 120 (19) (CG receiving vit D for 6 mo)

 

Followed to 1 y

 



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