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Reference;

Country;

Jadad Score for RCTsb

Population Description

Intervention/Duration

Bone Health Outcomes

Results

Before-and-after studies

Rajakumar et al., 2005

Healthy 6–10 y olds

Tanner stage I/II (81% I)

Skin type III/IV (81% IV); mean age 8.9 (1.2) y (range 6–10 y)

400 IU vit D/d (isoform not specified)

iPTH (Immulite iPTH chemiluminescent assay)

Serum 25OHD, mean (SD) (nmol/L)

Baseline: 60.0 (26.3)

49% < 50

71% < 75

United States

 

 

1 mo

 

 

 

 

 

Group 1 = 25OHD < 50 nmol/L at baseline: 38.5 (8.0)

Group 2 = 25OHD > 50 nmol/L at baseline: 80.3 (20.5)

 

 

 

1 mo (total group): 68.8 (18.8)

Group 1: 57.5 (16.0)

Group 2: 79.5 (14.5)

Increase in serum 25OHD was observed only in group 1

7/39 (18%) of group 1 continued to have a level < 50 nmol/L after 1 mo of supplementation

 

Vit D dietary intake: mean (SD) 277 (146) IU/d 16/41 (39%) dietary intake < 200 IU/d

 

 

 

 

 

Negative correlation of 25OHD with body weight (r = −0.378, p = 0.015) at baseline

 

n = 42

 

 

 

34% female

 

 

No significant differences at baseline or 1 mo in markers of bone turnover, 1,25(OH)2D or PTH between groups with 25OHD < 50 nmol/L or > 50 nmol/L at baseline

 

African American

 

 

NOTE: BMAD = bone mineral apparent density; BMC = bone mineral content; BMD = bone mineral density; CG = control group; DXA = dual-energy X-ray absorptiometry; FN = femoral neck; IG = intervention group; iPTH = intact parathyroid hormone; IU = International Units; LS = lumbar spine; LSES = lower socioeconomic status; mo = month(s); NA = not applicable; PTH = parathyroid hormone; RCT = randomized controlled trial; SD = standard deviation; SPA = single-photon absorptiometry; UK = United Kingdom; USES = upper socioeconomic status; vit = vitamin; wk = week(s); y = year(s).

aThis table has been truncated for the purposes of this chapter, but it can be found in its entirety in Appendix C.

bJadad score is based on a scale of 1 to 5. See Box 4-1 for details on the scoring system.

SOURCE: Modified from Cranney et al. (2007).



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