BOX 4-4
AHRQ Findings by Life Stage for Vitamin D and Calcium and BMC/BMD*
0–6 months: No data
7 months–2 years: No data
3–8 years: No data
9–18 years: One RCT showed that, compared with placebo, there was no significant effect of vitamin D3 (200 IU/day) plus calcium (1,000 mg/day) on BMC changes in healthy girls between 10 and 12 years of age.
19–50 years: No data
51–70 years: No new data were identified in AHRQ-Tufts
≥ 71 years: No new data were identified in AHRQ-Tufts
Postmenopause: Findings from the AHRQ-Ottawa report showed that vitamin D3 (≤ 800 IU/day) plus calcium (~500 mg/day) supplementation resulted in small increases in BMD of the spine, total body, femoral neck, and total hip in predominantly populations of late-menopausal women. Two of the three new RCTs showed a significant increase in hip or total BMD in postmenopausal women, comparing vitamin D3 or vitamin D2 (300 or 1,000 IU/day, respectively) plus calcium (1,200 mg/day) with placebo.
Pregnant and lactating women: No new data were identified in AHRQ-Tufts
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*Evidence from AHRQ-Ottawa; information from AHRQ-Tufts as noted.
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SOURCE: Modified from Chung et al. (2009).
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