The synopsis of this outcome is based on the same systematic review described under preeclampsia. The overall effects of calcium supplementation were not significant (among three RCTs in 13,091 randomized women RR = 1.10, 95% CI 0.88, 1.37). (Included in this meta-analysis are the two large trials mentioned in the preeclampsia section, which found no significant effects.)
Based on the above, there is no evidence for an effect of calcium supplementation on preterm births.
Detailed presentation (Table 75)
Relevant published systematic reviews (with meta-analyses)
The Cochrane review that was selected for preeclampsia was applicable for this outcome as well.176Table 75 shows that among three trials with pertinent information there was no significant effect of calcium supplementation on the proportion of infants who were small for gestational age.178,179
Findings by life stage
0 – 6 mo Based on a Cochrane review that synthesized data from three RCTs on 13,091 pregnant women, calcium supplementation has no significant effect on whether born infants were small for gestational age or not.
7 mo – 2 y Not applicable
3 – 8 y Not applicable
9 – 18 y Not applicable
19 – 50 y Not applicable
51 – 70 y Not applicable
≥71 y Not applicable
Postmenopause Not applicable
Pregnant & lactating women Not applicable