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APPENDIX

COMMITTEE ON TRENDS IN SCIENCE AND TECHNOLOGY RELEVANT TO THE BIOLOGICAL WEAPONS CONVENTION: AN INTERNATIONAL WORKSHOP

RODERICK J. FLOWER (Chair), Professor of Biochemical Pharmacology, William Harvey Research Institute, Queen Mary University of London, United Kingdom


HERNAN CHAIMOVICH, Superintendent General, Butantan Foundation, Professor of Biochemistry, Universidade de São Paulo, Brazil


NANCY D. CONNELL, Professor of Infectious Disease, University of Medicine and Dentistry of New Jersey


ANDRZEJ GÓRSKI, Professor of Medicine and Immunology, The Medical University of Warsaw, Vice President, Polish Academy of Sciences


LI HUANG, Director-General, Institute of Microbiology, Chinese Academy of Sciences


MAXWELL OTIM ONAPA, Deputy Executive Secretary, Uganda National Council for Science and Technology


MOHAMED IQBAL PARKER, Professor in Medical Biochemistry, University of Cape Town, South Africa, Director, International Centre for Genetic Engineering and Biotechnology, Cape Town


ANDREW PITT, Reader and Director of the Sir Henry Wellcome Functional Genomics Facility, University of Glasgow, Scotland


RALF TRAPP, Consultant, CBW Arms Control and Disarmament, France


LLOYD WHITMAN, Deputy Director, Center for Nanoscale Science and Technology, U.S. National Institute for Standards and Technology



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APPENDIX COMMITTEE ON TRENDS IN SCIENCE AND TECHNOLOGY RELEVANT TO THE BIOLOGICAL WEAPONS CONVENTION: AN INTERNATIONAL WORKSHOP RODERICK J. FLOWER (Chair), Professor of Biochemical Pharmacology, William Harvey Research Institute, Queen Mary University of London, United Kingdom HERNAN CHAIMOVICH, Superintendent General, Butantan Foundation, Professor of Biochemistry, Universidade de São Paulo, Brazil NANCY D. CONNELL, Professor of Infectious Disease, University of Medicine and Dentistry of New Jersey ANDRZEJ GÓRSKI, Professor of Medicine and Immunology, The Medical University of Warsaw, Vice President, Polish Academy of Sciences LI HUANG, Director-General, Institute of Microbiology, Chinese Academy of Sciences MAXWELL OTIM ONAPA, Deputy Executive Secretary, Uganda National Council for Science and Technology MOHAMED IQBAL PARKER, Professor in Medical Biochemistry, University of Cape Town, South Africa, Director, International Centre for Genetic Engineering and Biotechnology, Cape Town ANDREW PITT, Reader and Director of the Sir Henry Wellcome Functional Genomics Facility, University of Glasgow, Scotland RALF TRAPP, Consultant, CBW Arms Control and Disarmament, France LLOYD WHITMAN, Deputy Director, Center for Nanoscale Science and Technology, U.S. National Institute for Standards and Technology 39

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40 TRENDS IN SCIENCE AND TECHNOLOGY WORKSHOP RAPPORTEURS KATHERINE BOWMAN, Senior Program Officer, Board on Life Sciences, U.S. National Research Council KATHRYN HUGHES, Program Officer, Board on Chemical Sciences and Technology, U.S. National Research Council JO L. HUSBANDS, Scholar/Senior Project Director, Board on Life Sciences, U.S. National Research Council JAMES REVILL, Research Fellow, Science Policy Research Unit, University of Sussex, United Kingdom BENJAMIN RUSEK, Program Officer, Committee on International Security and Arms Control, U.S. National Research Council

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APPENDIX 41 WORKSHOP AGENDA Sunday, 31 October 6:00 PM Reception and Welcome Remarks from Sponsoring Organizations - Rod Flower, chair, Committee on Trends in Science and Technology Relevant to the Biological Weapons Convention: An International Workshop - Lei Zhang, Chinese Academy of Sciences - Andrzej Górski, chair, IAP Biosecurity Working Group - Iqbal Parker, International Union of Biochemistry and Molecular Biology - Stephen Lerner, International Union of Microbiological Societies - Meg Flanagan, Defense Threat Reduction Agency - Lorna Miller, UK Global Partnership Programme - Christopher Park, US Department of State Monday, 1 November 9:00 AM Plenary Session 1: Introduction to the Themes, Goals, and Context of the Workshop Chair: Andrzej Górski, Polish Academy of Sciences, Poland Welcome Address: Tao Xu, Director-General, Institute of Biophysics, Chinese Academy of Sciences Aims and Objectives of the Meeting – Roderick Flower, Queen Mary 1. University of London, UK The Biological Weapons Convention: A Brief Overview – Piers Millet, 2. BWC Implementation Support Unit, United Nations, Switzerland Introduction to framework for evaluating new science and technology – 3. Ralf Trapp, CBW Consultant, France Perspective from the Chinese Academy of Sciences – Li Huang, Institute 4. of Microbiology, Chinese Academy of Sciences, China Discussion 5. 10:45 AM Plenary Session 2: Developments in Design, Fabrication, and Production (A) Chair: Iqbal Parker, University of Cape Town, South Africa 1. Bioinformatics and Computational Tools – Etienne de Villiers, International Livestock Research Institute, Kenya 2. Systems Biology: Relevance to the Biological and Toxins Weapons Convention – Andrew Pitt, University of Glasgow, UK 3. Emerging Trends in Synthetic Biology – Pawan Dhar, University of Kerala, India 4. Discussion 1:15 PM Plenary Session 3: Developments in Design, Fabrication, and Production (B) Chair: Andrew Pitt, University of Glasgow, UK 1. Bioreactors and Transgenic Animals – Ryszard Słomski, Poznań University of Life Sciences, Poland

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42 TRENDS IN SCIENCE AND TECHNOLOGY 2. Transgenic Plants and Recombinant Pharmaceuticals – Julian Ma, St. Georges University of London, UK 3. Neuroscience Developments – James Eberwine, University of Pennsylvania School of Medicine, USA 4. Discussion 3:00 PM Plenary Session 4: Dispersal and Delivery Chair: Ralf Trapp, CBW Consultant, France 1. Aerosols and Aerobiology – Chad Roy, Tulane National Primate Research Center, USA 2. Nanostructured Delivery Systems for Drugs, Proteins and Cells – Jackie Ying, Institute of Bioengineering and Nanotechnology, Singapore 3. Commentary: Implications Stemming From Advances in Dual-Use Targeted Delivery Systems – Kathryn Nixdorff, Darmstadt University of Science and Technology, Germany 4. Discussion 4:15 PM Breakout Discussion Sessions 7:30 PM Special Event: “Strengthening the culture of responsibility with respect to dual use research and biosecurity” (videoteleconference). Organized by NIH/NSABB and the Chinese Academy of Sciences, in cooperation with the IAP, IUMS, IUBMB, and NAS Tuesday, 2 November 9:00 AM Plenary Session 5: Summary from Day 1 Chair: Maxwell Otim Onapa, Uganda National Council for Science and Technology, Uganda Presentations from Rapporteurs of Day 1 Breakout Sessions 1. Discussion 2. 9:30 AM Plenary Session 6: Detection, Identification, and Monitoring Chair: Lloyd Whitman, National Institute of Standards and Technology, USA 1. Postgenomic Technologies – Andrew Pitt, University of Glasgow, UK 2. Exploring an International Microbial Forensics Capability to Support Attribution and Advance Global Biosecurity – Randall Murch, Virginia Polytechnic Institute and State University, USA 3. Biosensors Overview – Gary Resnick, Los Alamos National Laboratory, USA 4. Biosensor Development – Ilya Kurochkin, M.V. Lomonosov Moscow State University, Russia 5. Remarks: Brief Summary of the Science used by the FBI in the Anthrax Attacks Case of 2001 - Nancy Connell, University of Medicine and Dentistry of New Jersey, USA 6. Discussion

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APPENDIX 43 11:15 AM Plenary Session 7: Defense and Countermeasures Chair: Anwar Nasim, COMSTECH, Pakistan 1. Vaccines and Medical Countermeasures – Nancy Connell, University of Medicine and Dentistry of New Jersey, USA 2. Monitoring and Molecular Diagnosis of Emerging Infectious Diseases – Raymond Lin, National Public Health Laboratory, Singapore 3. Agricultural Biosecurity: Threats to Crop Production – Michael Jeger, Imperial College London, UK 4. Discussion 1:45 PM Breakout Discussion Sessions 4:15 PM Plenary Session 8: Communication Chair: Hernan Chaimovich, Fundação Butantan, Brazil 1. How the Internet has Changed Scientific Interchanges – James Meadway, The Royal Society, UK 2. Influence of Technology on Scientific Collaboration: Indonesia Experience – Herawati Sudoyo, Eijkman Institute for Molecular Biology, Indonesia 3. Biological Risks – Future Trends: Conveying the Concept of Risk – Terence Taylor, International Council for the Life Sciences, USA 4. Discussion Wednesday, November 3 9:00 AM Plenary session 9: Summary from Day 2 Chair: Li Huang, Institute of Microbiology, Chinese Academy of Sciences, China 1. Presentations from Rapporteurs of Day 2 Breakout Sessions 2. Discussion of Days 1 and 2 10:30 AM Plenary session 10: Workshop Conclusions Chair: Roderick Flower, Queen Mary University of London, UK 1. Facilitated Discussion: Improving Scientific Input into the BWC 2. Discussion of Workshop Findings and Conclusions 3. Next Steps 12:00 PM Meeting Adjournment

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APPENDIX 45 PARTICIPANT LIST Katherine Bowman Gerald Epstein Board on Life Sciences Center for Science, Technology, and The U.S. National Academies Security Policy American Association for the Advancement Göran Bucht of Science Swedish Defense Research Establishment Meg Flanagan Hernan Chaimovich U.S. Defense Threat Reduction Agency Fundação Butantan University of São Paulo Rod Flower St. Barts and The London School of Teck-Mean Chua Medicine Asia Pacific Biosafety Association Queen Mary University of London Nancy Connell David R. Franz Department of Medicine Midwest Research Institute University of Medicine and Dentistry of New Jersey David Friedman Institute for National Security Studies Neil Davison Tel-Aviv University Security and Diplomacy The Royal Society Katsuhisa Furukawa Japan Science and Technology Agency Etienne De Villiers International Livestock Research Institute Andrzej Gorski Polish Academy of Sciences Pawan Dhar Centre for Systems and Synthetic Biology Anfeng Guo University of Kerala Visiting Fellow, Princeton University Beijing Science Technology and Security Gang Dong Center Chinese Academy of Military Medical Sciences Li Huang Institute of Microbiology Qi Dong Chinese Academy of Sciences Division of International Organization Bureau of International Cooperation Kathryn Hughes Chinese Academy of Sciences Board on Chemical Sciences and Technology Cris dos Remedios The U.S. National Academies International Union for Pure & Applied Biophysics Jo L.Husbands University of Sydney Board on Life Sciences The U.S. National Academies James Eberwine Department of Pharmacology Saied Jaradat University of Pennsylvania School of Princess Haya Biotechnology Center Medicine

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46 TRENDS IN SCIENCE AND TECHNOLOGY Michael J. Jeger Irma Makalinao Imperial College London Department of Pharmacology and Toxicology, College of Medicine Serhiy Komisarenko University of the Philippines Manila National Biosafety and Biosecurity Commission Robert Mathews Academy of Sciences of Ukraine NBC Arms Control Unit Defence Science and Technology Gabriele Kraatz-Wadsack Organisation Weapons of Mass Destruction Branch Office for Disarmament Affairs James Meadway The Royal Society Ilya Kurochkin Chemical Department Sue Meek M.V. Lomonosov Moscow State University Australian Academy of Science Valdas Laurinavicius Lorna Miller Institute of Biochemistry Defence Science and Technology Vilnius University Laboratory Stephen Lerner Piers Millett International Union of Microbiological BWC Implementation Support Unit Societies United Nations Wayne State University School of Medicine Randall Murch Ming Li Virginia Polytechnic Institute and State Beijing Institutes of Biological Science University Chinese Academy of Sciences Anwar Nasim Zhenjun Li OIC Standing Committee on Scientific and Department of Science & Education Technological Cooperation (COMSTECH) National Institute for Communicable Disease Control and Prevention Kathryn Nixdorff China CDC Darmstadt University of Technology Raymond Lin Godwin Haruna Ogbadu National Public Health Laboratory Sheda Science and Technology Complex Ministry of Health Maxwell Otim Onapa Shu Liu Uganda National Council for Science and Chinese Academy of Military Medical Technology Sciences Christopher Park Yidong Liu Bureau of International Security and Institute for the History of Natural Science Nonproliferation Chinese Academy of Sciences U.S. Department of State Julian Ma M. Iqbal Parker St George's Hospital Medical School International Centre for Genetic Engineering University of London and Biotechnology University of Cape Town

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APPENDIX 47 Graham Pearson Colonel Ben Steyn Department of Peace Studies Chemical and Biological Defence Advisor University of Bradford South African Military Health Service Lei Pei Herawati Sudoyo Organisation for International Dialogue & Eijkman Institute for Molecular Biology Conflict Management Leiv Sydnes Andrew Pitt Department of Chemistry University of Glasgow University of Bergen Yerlan Ramankulov Marlena Szalata National Center for Biotechnology of the Department of Biochemistry and Republic of Kazakhstan Biotechnology Poznan University of Life Sciences I. Gary Resnick Bioscience Division Terence Taylor Los Alamos National Laboratory International Council for the Life Sciences James Revill Ralf Trapp Science and Technology Policy Research Consultant, CBW Arms Control and University of Sussex Disarmament Chad Roy Jinglin Wang Tulane National Primate Research Center Institute of Microbiology and Epidemiology Tulane University School of Medicine Chinese Academy of Military Medical Sciences Benjamin Rusek Committee on International Security and Lei Wang Arms Control Chinese Academy of Military Medical The U.S. National Academies Sciences Nariyoshi Shinomiya Li Wang Department of Integrative Physiology and Chinese Academy of Military Medical Bio-Nano Medicine Sciences National Defense Medical College of Japan Lloyd Whitman Aleksandr Simonian Center for Nanoscale Science and Biosensing/CBET Technology National Science Foundation National Institute for Standards and Technology (NIST) Ryszard Slomski Department of Biochemistry and Angela Woodward Biotechnology Verification Research, Training and Poznan University of Life Sciences Information Centre (VERTIC) James Stack Jackie Ying Kansas State University Institute of Bioengineering and Great Plains Diagnostic Network Nanotechnology

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48 TRENDS IN SCIENCE AND TECHNOLOGY Zhiming Yuan Lianhui Zhu Wuhan Institute of Virology Chinese Academy of Military Medical Chinese Academy of Sciences Sciences Lei Zhang Enlin Zhu Institute of Biophysics Plant Protection and Plant Quarantine Chinese Academy of Sciences Division Ministry of Agriculture Xiushan Zhang Chinese Academy of Military Medical Sciences