1. What consequences of chronic diseases are most important (criteria to be decided and justified by the committee) to the nation’s health and economic well-being?

2. Which chronic diseases should be the focus of public health efforts to reduce disability and improve functioning and quality of life?

3 Which populations need to be the focus of interventions to reduce the consequences of chronic disease including the burden of disability, loss of productivity and functioning, health care costs, and reduced quality of life?

4. Which population-based interventions can help achieve outcomes that maintain or improve quality of life, functioning, and disability?

• What is the evidence on effectiveness of interventions on these outcomes?

• To what extent do the interventions that address these outcomes also affect clinical outcomes?

• To what extent can policy, environmental, and systems change achieve these outcomes?

5. How can public health surveillance be used to inform into public policy decisions to minimize adverse life impacts?

6. What policy priorities could advance efforts to improve life impacts of chronic disease?

7. What is the role of primary prevention (for those at highest risk), secondary, and tertiary prevention of chronic disease in reducing or minimizing life impacts (e.g., preventing diabetes in pre-diabetics, preventing incidence of disability in people with arthritis, preventing recurrence of cancer, managing complications of cardiovascular disease)?

In conducting this work, the committee was asked to consider the following diseases: heart disease and stroke, diabetes, arthritis, depression, respiratory problems (asthma, chronic obstructive pulmonary disease [COPD]), chronic neurological conditions, and cancer. These diseases or categories of disease were included in the statement of task as examples of diseases for the committee to consider, not as a prescriptive set of diseases to include in the report. In fact, the committee was advised by the sponsors of this report not to focus on the common high-mortality diseases, but rather to consider diseases that have the potential to cause or actually do cause functional limitations and/or disabilities. This guidance thus allowed the committee to consider a wide range of chronic diseases, including all chronic diseases, in the context of living well. With respect to primary prevention, the committee was asked to consider prevention only among individuals with high-risk factors (e.g., prediabetes). Chronic illnesses related



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