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Acronyms and Abbreviations
ACR acute cellular rejection
AHRQ Agency for Healthcare Research and Quality
ALK anaplastic lymphoma kinase
ASCO American Society of Clinical Oncology
BCBS Blue Cross Blue Shield
CAD coronary artery disease
CAP College of American Pathologists
CARGO Cardiac Allograft Rejection Gene Expression Observational
CDC Centers for Disease Control and Prevention
CI confidence interval
CLIA Clinical Laboratory Improvement Amendments of 1988
CMF cyclophosphamide, methotrexate, and fluorouracil
CMS Centers for Medicare & Medicaid Services
CMV cytomegalovirus
COI conflict of interest
CONSORT Consolidated Standards of Reporting Trials
CPRC Cancer Center Protocol Review Committee
CTAF California Technology Assessment Forum
CTMS clinical trial management systems
CTSA Clinical Translational Science Award
dbGaP database of Genotypes and Phenotypes
DNA deoxyribonucleic acid
323
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324 EVOLUTION OF TRANSLATIONAL OMICS
DOD Department of Defense
DSMB data safety monitoring board
EGAPP Evaluation of Genomic Applications in Practice and
Prevention
EMB endomyocardial biopsy
EQUATOR Enhancing the QUAlity and Transparency Of health
Research
FDA Food and Drug Administration
FFATA Federal Funding Accountability and Transparency Act
FFPE formalin-fixed, paraffin-embedded
FISH fluorescence in situ hybridization
HER2 human epidermal growth factor receptor 2
HHS U.S. Department of Health and Human Services
HPV human papillomavirus
HR hazard ratio
ICMJE International Committee of Medical Journal Editors
IDE investigational device exemption
IDMC independent data monitoring committee
IHC immunohistochemistry
IMAGE Invasive Monitoring Attenuation through Gene Expression
IND investigational new drug
IOM Institute of Medicine
IOTF Interagency Oncology Task Force
IRB Institutional Review Board
ISHLT International Society for Heart and Lung Transplantation
ISO International Organization for Standardization
IVD in vitro diagnostic
IVDMIA in vitro diagnostic multivariate index assay
LDT laboratory-developed test
LMS Lung Metagene Score
MALDI matrix-assisted laser desorption/ionization
MALDI-TOF time-of-flight mass spectrometer
MF methotrexate and fluorouracil
MIAME Minimum Information About a Microarray Experiment
MIBBI Minimum Information for Biological and Biomedical
Investigations
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325
ACRONYMS AND ABBREVIATIONS
MINDACT Microarray In Node negative and 1-3 positive lymph node
Disease may Avoid ChemoTherapy
miRNA micro RNA
MoS Manual of Style: A Guide for Authors and Editors
MRI magnetic resonance imaging
mRNA messenger RNA
MS mass spectrometry
NAS National Academy of Sciences
NCCN National Comprehensive Cancer Network
NCI National Cancer Institute
ncRNA non-coding RNA
NIH National Institutes of Health
NIST National Institute of Standards and Technology
NMR nuclear magnetic resonance
NOCEDP National Ovarian Cancer Early Detection Program
NRC National Research Council
NSABP National Surgical Adjuvant Breast and Bowel Project
OHRP Office of Human Research Protections
ORI Office of Research Integrity
PBMC peripheral blood mononuclear cells
PHS Public Health Service
PI principal investigator
PMA premarket approval
PRISMA Preferred Reporting Items for Systematic Reviews and
Meta-Analyses
PSA prostate-specific antigen
QMS quality management systems
qRT-PCR quantitative reverse-transcriptase polymerase chain reaction
RCT randomized controlled trial
REMARK REporting recommendations for tumor MARKer
prognostic studies
RNA ribonucleic acid
RNAseq RNA sequencing
rRNA ribosomal RNA
RS Recurrence Score
RT-PCR reverse-transcriptase polymerase chain reaction
RxPONDER Rx for POsitive NoDe, Endocrine Responsive breast
cancer
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326 EVOLUTION OF TRANSLATIONAL OMICS
SELDI surface-enhanced laser desorption/ionization
SELDI-TOF SELDI time-of-flight mass spectrometer
SERMs selective estrogen receptor modulators
SGO Society of Gynecologic Oncology
SNP single nucleotide polymorphism
SOP standard operating procedure
SPCI Simone Protective Cancer Institute
SQUIRE Standards for QUality Improvement Reporting Excellence
SRM selected reaction monitoring
SS similarity score
STARD STAndards for the Reporting of Diagnostic accuracy studies
STROBE STrengthening the Reporting of OBservational studies in
Epidemiology
TAILORx Trial Assigning IndividuaLized Options for Treatment
TEC Blue Cross Blue Shield Technology Evaluation Center
TMQF Translational Medicine Quality Framework
tRNA transfer RNA
USPSTF U.S. Preventive Services Task Force
