A

References

Albert, M.S., S.T. DeKosky, D. Dickson, B. Dubois, H.H. Feldman, N.C. Fox, A. Gamst, D.M. Holtzman, W.J. Jagust, R.C. Petersen, P.J. Snyder, M.C. Carrillo, B. Thies, and C.H. Phelps. 2011. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging–Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):270-279.

Caselli, R.J., A.C. Dueck, D. Osborne, M.N. Sabbagh, D.J. Connor, G.L. Ahern, L.C. Baxter, S.Z. Rapcsak, J. Shi, B.K. Woodruff, D.E. Locke, C.H. Snyder, G.E. Alexander, R. Rademakers, and E.M. Reiman. 2009. Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. N Engl J Med 361(3):255-263.

Cleary, J.P., D.M. Walsh, J.J. Hofmeister, G.M. Shankar, M.A. Kuskowski, D.J. Selkoe, and K.H. Ashe. 2005. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci 8(1):79-84.

Cleeman, J.I., and C. Lenfant. 1998. The National Cholesterol Education Program. JAMA 280(24):2099-2104.

Cohen, J.C., E. Boerwinkle, T.H. Mosley Jr., and H.H. Hobbs. 2006. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 354(12):1264-1272.

Consensus Conference. 1985. Lowering blood cholesterol to prevent heart disease. J Am Med Assoc 253:2080-2086.

Dubois, B., H.H. Feldman, C. Jacova, S.T. Dekosky, P. Barberger-Gateau, J. Cummings, A. Delacourte, D. Galasko, S. Gauthier, G. Jicha, K. Meguro, J. O’Brien, F. Pasquier, P. Robert, M. Rossor, S. Salloway, Y. Stern, P.J. Visser, and P. Scheltens. 2007. Research criteria for the diagnosis of Alzheimer’s disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol. 6(8):734-746.

Dubois, B., H.H. Feldman, C. Jacova, J.L. Cummings, S.T. Dekosky, P. Barberger-Gateau, A. Delacourte, G. Frisoni, N.C. Fox, D. Galasko, S. Gauthier, H. Hampel, G.A. Jicha, K. Meguro, J. O’Brien, F. Pasquier, P. Robert, M. Rossor, S. Salloway, M. Sarazin, L.C. de Souza, Y. Stern, P.J. Visser, and P. Scheltens. 2010. Revising the definition of Alzheimer’s disease: A new lexicon. Lancet Neurol 9(11):1118-1127.



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A References Albert, M.S., S.T. DeKosky, D. Dickson, B. Dubois, H.H. Feldman, N.C. Fox, A. Gamst, D.M. Holtzman, W.J. Jagust, R.C. Petersen, P.J. Snyder, M.C. Carrillo, B. Thies, and C.H. Phelps. 2011. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging–Alzheimer’s Associa- tion workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):270-279. Caselli, R.J., A.C. Dueck, D. Osborne, M.N. Sabbagh, D.J. Connor, G.L. Ahern, L.C. Baxter, S.Z. Rapcsak, J. Shi, B.K. Woodruff, D.E. Locke, C.H. Snyder, G.E. Alexander, R. Rademakers, and E.M. Reiman. 2009. Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. N Engl J Med 361(3):255-263. Cleary, J.P., D.M. Walsh, J.J. Hofmeister, G.M. Shankar, M.A. Kuskowski, D.J. Selkoe, and K.H. Ashe. 2005. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci 8(1):79-84. Cleeman, J.I., and C. Lenfant. 1998. The National Cholesterol Education Program. JAMA 280(24):2099-2104. Cohen, J.C., E. Boerwinkle, T.H. Mosley Jr., and H.H. Hobbs. 2006. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 354(12):1264-1272. Consensus Conference. 1985. Lowering blood cholesterol to prevent heart disease. J Am Med Assoc 253:2080-2086. Dubois, B., H.H. Feldman, C. Jacova, S.T. Dekosky, P. Barberger-Gateau, J. Cummings, A. Delacourte, D. Galasko, S. Gauthier, G. Jicha, K. Meguro, J. O’Brien, F. Pasquier, P. Robert, M. Rossor, S. Salloway, Y. Stern, P.J. Visser, and P. Scheltens. 2007. Research criteria for the diagnosis of Alzheimer’s disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol. 6(8):734-746. Dubois, B., H.H. Feldman, C. Jacova, J.L. Cummings, S.T. Dekosky, P. Barberger-Gateau, A. Delacourte, G. Frisoni, N.C. Fox, D. Galasko, S. Gauthier, H. Hampel, G.A. Jicha, K. Meguro, J. O’Brien, F. Pasquier, P. Robert, M. Rossor, S. Salloway, M. Sarazin, L.C. de Souza, Y. Stern, P.J. Visser, and P. Scheltens. 2010. Revising the definition of Alzheimer’s disease: A new lexicon. Lancet Neurol 9(11):1118-1127. 15

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16 ALZHEIMER’S DIAGNOSTIC GUIDELINES Enos, W.F., R.H. Holmes, and J. Beyer. 1953. Coronary disease among United States soldiers killed in action in Korea; preliminary report. JAMA 152(12):1090-1093. Ford, E.S., U.A. Ajani, J.B. Croft, J.A. Critchley, D.R. Labarthe, T.E. Kottke, W.H. Giles, and S. Capewell. 2007. Explaining the decrease in U.S. deaths from coronary disease, 1980- 2000. N Engl J Med 356(23):2388-2398. Jack, C.R. Jr., M.S. Albert, D.S. Knopman, G.M. McKhann, R.A. Sperling, M.C. Carrillo, B. Thies, and C.H. Phelps. 2011. Introduction to the recommendations from the National Institute on Aging–Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):257-262. Kastelein, J.J.P. 2005. The realities of dyslipidaemia: What do the studies tell us? European Heart Journal Supplements 7(Supplement F):F27-F33. Lambert, M.P., A.K. Barlow, B.A. Chromy, C. Edwards, R. Freed, M. Liosatos, T.E. Morgan, I. Rozovsky, B. Trommer, K.L. Viola, P. Wals, C. Zhang, C.E. Finch, G.A. Krafft, and W.L. Klein. 1998. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA 95(11):6448-6453. Libby, P., P.M. Ridker, and G.K. Hansson. 2011. Progress and challenges in translating the biology of atherosclerosis. Nature 473:317-325. Lipid Research Clinics Program. 1984a. The Lipid Research Clinics Coronary Primary Prevention Trial Results: I. Reduction in incidence of coronary heart disease. JAMA 251(3):351-364. Lipid Research Clinics Program. 1984b. The Lipid Research Clinics Coronary Primary Preven- tion Trial Results: II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 251(3):365-374. Mahley, R.W., K.H. Weisgarber, and Y. Huang. 2006. Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease. Proc Natl Acad Sci USA 103:5644-5651. McKhann, G.M., D.S. Knopman, H. Chertkow, B.T. Hyman, C.R. Jack Jr., C.H. Kawas, W.E. Klunk, W.J. Koroshetz, J.J. Manly, R. Mayeux, R.C. Mohs, J.C. Morris, M.N. Rossor, P. Scheltens, M.C. Carrillo, B. Thies, S. Weintraub, and C.H. Phelps. 2011. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):263-269. Puzzo, D., L. Privitera, M. Fa, A. Staniszewski, G. Hashimoto, F. Aziz, M. Sakurai, E.M. Ribe, C.M. Troy, M. Mercken, S.S. Jung, A. Palmeri, and O. Arancio. 2011. Endogenous amyloid-b is necessary for hippocampal synaptic plasticity and memory. Ann Neurol 69(5):819-830. Robinson, J.G. 2008. Models for describing relations among the various statin drugs, low- density lipoprotein cholesterol lowering, pleiotropic effects, and cardiovascular risk. Am J Cardiol 101(7):1009-1015. Roger, V.L., A.S. Go, D.M. Lloyd-Jones, R.J. Adams, J.D. Berry, T.M. Brown, M.R. Carnethon, S. Dai, G. de Simone, E.S. Ford, C.S. Fox, H.J. Fullerton, C. Gillespie, K.J. Greenlund, S.M. Hailpern, J.A. Heit, P.M. Ho, V.J. Howard, B.M. Kissela, S.J. Kittner, D.T. Lackland, J.H. Lichtman, L.D. Lisabeth, D.M. Makuc, G.M. Marcus, A. Marelli, D.B. Matchar, M.M. McDermott, J.B. Meigs, C.S. Moy, D. Mozaffarian, M.E. Mussolino, G. Nichol, N.P. Paynter, W.D. Rosamond, P.D. Sorlie, R.S. Stafford, T.N. Turan, M.B. Turner, N.D. Wong, and J. Wylie-Rosett. 2011. Heart disease and stroke statistics—2011 update: A report from the American Heart Association. Circulation 123(4):e18-e209.

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17 APPENDIX A Sperling, R.A., P.S. Aisen, L.A. Beckett, D.A. Bennett, S. Craft, A.M. Fagan, T. Iwatsubo, C.R. Jack Jr., J. Kaye, T.J. Montine, D.C. Park, E.M. Reiman, C.C. Rowe, E. Siemers, Y. Stern, K. Yaffe, M.C. Carrillo, B. Thies, M. Morrison-Bogorad, M.V. Wagster, and C.H. Phelps. 2011. Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging–Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):280-292. Steinberg, D. 2006. An interpretive history of the cholesterol controversy, part V: The discov- ery of the statins and the end of the controversy. J Lipid Res 47:1339-1351. Tuzcu, E.M., S.R. Kapadia, E. Tutar, K.M. Ziada, R.E. Hobbs, P.M. McCarthy, J.B. Young, and S.E. Nissen. 2001. High prevalence of coronary atherosclerosis in asymptom- atic teenagers and young adults: Evidence from intravascular ultrasound. Circulation 103(22): 2705-2710. Weyer, S.W., M. Klevanski, A. Delekate, V. Voikar, D. Aydin, M. Hick, M. Filippov, N. Drost, K.L. Schaller, M. Saar, M.A. Vogt, P. Gass, A. Samanta, A. Jäschke, M. Korte, D.P. Wolfer, J.H. Caldwell and U.C. Müller. 2011. APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J 30:2266-2280.

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