Observations and next steps

This report is intended to introduce potential users to the concept of SMART Vaccines and to encourage stakeholders to inform the development of SMART Vaccines 1.0 in Phase II of this study. The committee will next enhance SMART Vaccines Beta, test its use with three additional vaccine candidates of domestic and global importance, and further improve the user interface as part of the development of SMART Vaccines 1.0.

The value of SMART Vaccines will depend, in part, on data that need to be generated as vaccine candidates evolve and as disease epidemiology becomes better characterized in different parts of the world. In the future—beyond Phase II—an active community of users and an open-source environment would likely lead to future enhancement of the SMART Vaccines’ capabilities. Potential enhancements could include creation and sharing of databases for populations from different countries, the enhancement of validation tools and user interface, and the development of ways to address the risk and uncertainty surrounding the characterization of vaccines that have not yet been developed. This study is the first step in moving toward these goals.



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