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(clinical
~ I - ~
BUT
Directions for a New Program
Committee to Advise the Public Health Service
on Clinical Practice Guidelines
Institute of Medicine
Marilyn J. Field and Kathleen N. Lohr, editors
NATIONAL ACADEMY PRESS
Washington, D.C. 1990
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NOTICE: The project that is the subject of this report was approved By the Governing
Board of the National Research Council, whose members are drawn from the councils of
the National Academy of Sciences, the National Academy of Engineering, and the Institute
of Medicine. The members of the committee responsible for the report were chosen for
their special competencies and with regard for appropriate balance.
This report has been reviewed by a group other than the authors according to
procedures approved ~ a Report Review Committee consisting of members of the National
Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.
The Institute of Medicine was chartered in 1970 by the National Academy of Sciences
to enlist distinguished membem of the appropriate professions in the examination of policy
matters pertaining to the health of the public. In this, the Institute acts under both
the Academies 1863 congressional charter responsibility to be an adviser to the federal
government and its own initiative in identifying issues of medical care, research, and
education.
This project was supported by the Department of Health and Human Services,
Contract No. 2~-90 0018. The views presented are those of the Institute of Medicine
Committee to Advise the Public Health Service on Clinical Practice Guidelines and are
not necessarily those of the funding organization. The Andrew W. Mellon Foundation
contribution to independent Institute of Medicine funds was also used to support the
project.
Library of Congress Catalog Card Number 90 062881
International Standard Book Number 0-309 04346-8
Publication IOM-90 08
No part of this boolc may be reproduced by any mechanical, photographic, or electronic
process, or in the form of a phonographic recording, nor may it be stored in a retrieval
system, transmitted, or otherwise copied for public or private use, without written permission
from the publisher, except for the purpose of official use By the U.S. Government.
Additional copies of this report are available from:
National Academy Press
2101 Constitution Avenue, N.W.
Washington, DC 20418
S-229
Printed in the United States of America
First Printing, September 1990
Second Printing, November 1991
Third Printing, November 1992
Fourth Painting, January 1994
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COMMITTEE TO ADVISE THE PUBLIC HEALTH SERVICE
ON CLINICAL PRACTICE GUIDELINES
JEROME H. GROSSMAN,* Chair, Chairman and Chief Executive
Officer, New England Medical Center, Inc., Boston, Massachusetts
HUGH P. H. BOWER, Family Practice, Bradford, Vermont
ROBERT H. BROOK,* Deputy Director, Health Program, The RAND
Corporation, Santa Monica, California
ARTHUR J. DONOVAN, Professor and Chairman, Department of
Surgery, University of Southern California, Los Angeles, California
DAVID M. EDDY,$ J. Alexander McMahon Professor of Health Poligy
and Management, Duke University, Durham, North Carolina
RICHARD D. FLOYD, Practice of Surgery, Lexington, Kentucly
ALICE G. GOSFIELD, Attorney, Alice G. Gosfield & Associates, P.C.,
Philadelphia, Pennsylvania
MICHAEL ~ W. HA11WICK, Practice of Internal Medicine,
Annandale, Virginia
CLARK C. HAVIGHURST,* William Neal Reynolds Professor of Law,
Duke University, Durham, North Carolina
ADA SUE HINSHAW,* Director, National Center for Nursing Research,
National Institutes of Health, Bethesda, Maryland
JOHN T. KELLY, Director, Once of Quality Assurance, American
Medical Association, Chicago, Illinois
DONALD G. LANGSLEY, Executive Vice President, American Board of
Medical Specialties, Evanston, Illinois
LAWRENCE C. MORRIS, Consultant in Health Care Finance, Wilmette,
Illinois
JOACHIM L. OPITZ, Department of Physician Medicine and
Rehabilitation, Mayo Clinic, Rochester, Minnesota
JOHN C. PETERSON III, Director of Medical Affairs, Professional
Review Organization for Washington, Seattle, Washington
ELLISON C. PIERCE, JR., Chairman, Department of Anaesthesia, New
England Deaconess Hospital, Boston, Massachusetts
BRENDA RICHARDSON, President, Massachusetts Peer Review
Organization, Boston, Massachusetts
LOUISE B. RUSSELL,$ Research Professor of Economics, Rutgers
University, New Brunswick, New Jersey
* Institute of Medicine member
. . .
111
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WILLIAM B. STASON, Director, Northeast Health Services, Research &
Development Field Program, Veterans Administration Medical
Center, West Roxbu~y, Massachusetts
MICHAEL ~ STOCKER, Executive Vice President, U.S. Healthcare,
Paramus, New Jersey
JAMES J. STRAIN, Professor and Director, Division of Behavioral
Medicine and Consultation Psychiatry, Mt. Sinai School of Medicine,
New York, New York
LINDA JOHNSON WHITE, Director, Department of Scientific Polipy,
American College of Physicians, Philadelphia, Pennsylvania
CONSTANCE M. WINSLOW, Medical Director, Research and Program
Development, AEtna Life and Casually, Hartford, Connecticut
STUDY STAFF
KARL D. YORDY, Director, Division of Health Care Services
MARILYN J. FIELD, Study Co-Director
KATHLEEN N. LOHR, Study Co-Director
MOLLA S. DONALDSON, Senior Staff Officer
THELMA COX, Project Secretary
DONALD TILLER, Administrative Assistant
1V
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Acknowledgments
This project was shaped by the work of two earlier Institute of Medicine
committees: the Committee on Utilization Management by Third Parties
and the Committee lo Design a Strategy for Quality Review and Assurance
in Medicare. The report of the first committee was issued in October 1989
and the report of the second, in March 1990. Some of the substantive
groundwork for this report was laid by an expert panel convened for the
quality assurance project to consider desirable characteristics of quality
of care indicators. That panel consisted of William ~ Causey, Arthur J.
Donovan, Leonard S. Dreifus, David M. Eddy, Lesley Fishelman, Sheldon
Greenfield, Robert J. Marder, Jane L. Neumann, Bruce Perry, and Ralph
Schaffarzick
Both the utilization management and quality assurance committees
made recommendations for further work on the development and use
of clinical practice guidelines that led to a project planning meeting in
November 1989. The meeting was chaired by Jerome H. Grossman, and
the participants were Peter Bouxsein, J. Jarrett Clinton, Arthur J. Donovan,
David M. Eddy, Sheldon Greenfield, Clark C. Havighurst, Neil Hollander,
Carmault B. Jackson, Jr., John T. Kelly, Marie Michnich, Joel E. Miller,
William H. Moncreif, Jr., Charles E. Phelps, William L. Roper, Ralph
Schaflarzick, Richard S. Sharpe, Linda Johnson White, and Sally Hart
Wilson.
As background for the planning meeting and the study committee,
Anne-Marie Audet and Sheldon Greenfield of the Institute for the Ad-
vancement of Health and Medical Care of the New England Medical
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Center, Inc., conducted a focused survey of prototypical initiatives on
clinical practice guidelines. Marilyn Field, study co-director, prepared a
background case study of mammography screening guidelines. Dr. Green-
field also made a presentation to the study committee as did Mark R.
Chassin of Value Health Sciences. IOM Scholar-in-Residence Patrick Mat-
tingly and Robert Wood Johnson Fellow Philip Goodman provided useful
suggestions and information. Stephen King, director of the Forum for
Quality and Effectiveness in Health Care, Agency for Health Care Policy
and Research, was always helpful in providing necessary information on
the agency. In addition, he briefed the study committee at its February and
April meetings.
From January through March 1990, Don Tiller kept the study oper-
ational by overseeing the work of a series of temporary secretaries until
Suzanna Gilbert began work in April. Marilyn Field and Kathleen Lohr
had primary responsibility for writing the report with assistance from Molla
Donaldson, who also prepared two sets of examples of practice guidelines
for the committee's examination. Leah Mazade copyedited the report. The
editors also acknowledge the constructive comments of those who reviewed
the report under Nanona1 Research Council procedures.
vi
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Contents
SUMMARY
1 INTRODUCTION AD BACKGROUND
DEFINITIONS OF KEY TERMS
1
19
33
3 ATTRIBUTES OF GOOD PRACTICE GUIDELINES 52
4 IMPLEMENTATION AND EVALUATION
5 CONCLUSIONS AND RECOMMENDATIONS
APPENDICES
A THE OMNIBUS BUDGET RECONCILIATION
ACT OF 1989
B EXAMPLES OF PRACTICE GUIDELINES
C
78
96
107
128
NEXT STEPS FOR THE INSTITUTE OF MEDICINE 149
D BIOGRAPHIES OF COMMITTEE MEMBERS
. .
V11
151
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