extracts had slightly increased levels of serum and urinary aluminum compared with those in age-matched controls receiving aqueous extracts, but aluminum levels in these patients did not fall outside the broad range of normal values (Glinert and Burnatowska-Hledin, 1988). Patients were estimated in this study to receive, on average, about 2.5 mg of aluminum per injection, with injections being given every 2 to 4 weeks for a period of 3 to 5 years. The DPT vaccines used in the United States are reported to contain not more than 0.25 to 0.8 mg of aluminum per 0.5-ml injection (Physicians' Desk Reference, 1989). One study suggested that use of aluminum-adsorbed DPT was associated with fewer febrile reactions than use of unabsorbed DPT vaccine was (Waight et al., 1983).
The possibility has been raised that the aluminum content of DPT vaccines might play a role in some of the adverse events that occur, or that are suspected to occur, in association with DPT immunization, particularly encephalopathy. However, there are no data to indicate that such a relationship exists.
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