NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.

The Institute of Medicine was chartered in 1970 by the National Academy of Sciences to enlist distinguished members of the appropriate professions in the examination of policy matters pertaining to the health of the public. In this, the Institute acts under both the Academy's 1863 congressional charter responsibility to be an advisor to the federal government and its own initiative in identifying issues of medical care, research, and education.

The work on which this publication is based was performed pursuant to Contract No. 278-89-003 with the National Institute of Mental Health, Public Health Service, Department of Health and Human Services. Funds for this contract were provided by the National Institute of Mental Health, the National Institute of Drug Abuse, and the National Science Foundation (under NSF Agreement No. BNS-8913554).

Library of Congress Cataloging-in-Publication Data

Institute of Medicine (U.S.). Committee on a National Neural Circuitry Database.

Mapping the brain and its functions: integrating enabling technologies into neuroscience research / Committee on a National Neural Circuitry Database, Division of Health Sciences Policy, Division of Biobehavioral Sciences and Mental Health, Institute of Medicine; Constance M. Pechura and Joseph D. Martin, editors.

p. cm. — (Publication ; no. IOM-91-08)

Includes bibliographical references and index.

1. Brain—Research—Data processing—Congresses. 2. Brain mapping—Congresses. I. Pechura, Constance M. II. Martin, Joseph B., 1938-. III. Title. IV. Series: IOM publication ; 91-08.

[DNLM: 1. Brain—physiology. 2. Brain Mapping. 3. Medical Informatics. 4. Neurosciences. 5. Research. WL 335 I59m]

QP376.I516 1991

612.8′2—dc20

DNLM/DLC

for Library of Congress

91-4832

CIP

No part of this book may be reproduced by any mechanical, photographic, or electronic process, or in the form of a phonographic recording, nor may it be stored in a retrieval system, transmitted, or otherwise copied for public or private use, without written permission from the publisher, except for the purpose of official use by the United States Government.

The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and religions since the beginning of recorded history. The image adopted as a logotype by the Institute of Medicine is based on a relief carving from ancient Greece, now held by the Staatlichemuseen in Berlin.